Medicine - Clinical Immunology

Projects

Projects per year 1984 2004 2006 2007 2009 2011 2012 2017 2023

• 11 Active
• 112 Finished

Projects per year

Search results

• Finished

  Mechanistic modeling of epigenetic modifier mutations in human pluripotent stem cell-derived immune cells

  Byun, M.

  National Institute of Allergy and Infectious Diseases

  1/02/22 → 31/01/23

  Project: Research

  • Pluripotent Stem Cells 100%
  • Epigenomics 74%
  • Mutation 63%
  • Hematologic Diseases 49%
  • Hematologic Neoplasms 43%

• Toll-like Receptor Control of MHC Class I Endocytosis

  Blander, J.

  National Institute of Allergy and Infectious Diseases

  1/02/22 → 31/01/23

  Project: Research

  • Endocytosis 100%
  • Toll-Like Receptors 81%
  • Viruses 66%
  • Peptides 63%
  • Dengue 56%

• Childhood Asthma in Urban Settings

  Busse, P., Bunyavanich, S. & Wisnivesky, J. P.

  National Institute of Allergy and Infectious Diseases

  15/04/21 → 31/03/22

  Project: Research

  • Asthma 100%
  • National Institute of Allergy and Infectious Diseases (U.S.) 33%
  • Research Personnel 29%
  • Systems Biology 25%
  • N,N-dimethylarginine 14%

• Innate and Adaptive Immune Consequences of Necroptosis

  Blander, J.

  National Institute of Allergy and Infectious Diseases

  17/06/20 → 31/05/21

  Project: Research

  • Necroptosis 100%
  • Apoptosis 31%
  • Phagocytes 18%
  • Epithelial Cells 16%
  • Inflammation 13%

• Mechanisms associated with diet-induced colitis

  Lira, S. & Lira, S. A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/02/20 → 31/01/23

  Project: Research

  • colitis 100%
  • inflammatory bowel disease 89%
  • cytokines 78%
  • Colitis 61%
  • Interleukin-23 55%

• Mitochondrial DNA biomarkers to assess responses to changes in personal environmental exposures in pediatric urban asthma

  Miller, R. L. & Miller, R.

  National Institute of Environmental Health Sciences

  30/01/20 → 31/08/21

  Project: Research

  • Environmental Exposure 100%
  • Mitochondrial DNA 99%
  • Asthma 88%
  • Biomarkers 69%
  • Pediatrics 57%

• Cellular and molecular characterization of LIG1 mutations causing a spectrum of primary immune deficiencies

  O’Brien, P. J. & Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  19/06/19 → 31/05/21

  Project: Research

  • Primary Immunodeficiency Diseases 100%
  • DNA Replication 73%
  • Alleles 53%
  • Ligases 53%
  • Mutation 44%

• Develop functional screening and genetic diagnosis for inborn errors in the NF-kappaB pathways

  Guennoun, A. A., Marr, N. N., Fuleihan, R. R., Lo, B. B., Cunningham-Rundles, C., Casanova, J. J. & Zhang, Q. Q.

  Qatar National Research Fund

  15/06/18 → 14/04/22

  Project: Research

  • Primary Immunodeficiency Diseases 100%
  • Genetic Testing 44%
  • NF-kappa B 42%
  • Qatar 29%
  • Mutation 22%

• Administrative Core

  Cunningham-Rundles, C. & Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/05/17 → 31/07/22

  Project: Research

  • Research Personnel 100%
  • Direction compound 17%

• Cell and Tissue Core

  Furtado, G. G. C. & Furtado, G.

  National Institute of Allergy and Infectious Diseases

  1/05/17 → 31/07/22

  Project: Research

  • tissues 100%
  • RNA 89%
  • flow cytometry 86%
  • gastrointestinal endoscopy 81%
  • cells 71%

• Blocks to B Cell Memory

  Cunningham-Rundles, C. & Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/05/17 → 31/07/22

  Project: Research

  • B-Lymphocytes 100%
  • Common Variable Immunodeficiency 80%
  • Plasma Cells 28%
  • Autoimmunity 28%
  • Transmembrane Activator and CAML Interactor Protein 27%

• Immunometabolism of IgA-Microbiota Interaction in Gut Homeostasis and Inflammation

  Cerutti, A. & Cerutti, A.

  National Institute of Allergy and Infectious Diseases

  1/05/17 → 31/07/22

  Project: Research

  • Microbiota 100%
  • Immunoglobulin A 94%
  • Secretory Immunoglobulin A 88%
  • Homeostasis 67%
  • Inflammation 54%

• Patient Core

  Cunningham-Rundles, C. & Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/05/17 → 31/07/22

  Project: Research

  • Research Ethics Committees 100%
  • Ambulatory Care 94%
  • Confidentiality 57%
  • Research Personnel 49%
  • Patient Selection 41%

• Novel vita-vaccine formula combines safety of dead and efficacy of live vaccines

  Blander, J.

  National Institute of Allergy and Infectious Diseases

  1/04/17 → 31/08/21

  Project: Research

  • Vaccines 100%
  • Safety 66%
  • Bacterial RNA 53%
  • Pathogen-Associated Molecular Pattern Molecules 39%
  • Subunit Vaccines 35%

• Role of apoptosis in the intestinal epithelium during homeostasis and disease

  Blander, J.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/17 → 31/03/21

  Project: Research

  • intestinal mucosa 100%
  • inflammatory bowel disease 90%
  • apoptosis 88%
  • homeostasis 69%
  • phagocytes 59%

• Mechanism of autoimmune hepatitis development in a novel mouse model

  Alexandropoulos, K.

  National Institute of Diabetes and Digestive and Kidney Diseases

  20/07/16 → 30/06/21

  Project: Research

  • Autoimmune Hepatitis 100%
  • Autoantigens 28%
  • T-Lymphocytes 28%
  • Liver 23%
  • Microbiota 19%

• Non-Canonical Cross-presentation in Dendritic Cells Upon TAP Blockade

  Blander, J. & Blander, J. M.

  National Institute of Allergy and Infectious Diseases

  1/02/16 → 31/01/21

  Project: Research

  • Cross-Priming 100%
  • Major Histocompatibility Complex 69%
  • Dendritic Cells 55%
  • Antigens 24%
  • T-Lymphocytes 24%

• Bacterial metabolites, short chain fatty acids, regulation of mucosal IgA responses

  Grasset, E.

  Vetenskapsrådet

  1/01/16 → 31/12/18

  Project: Research

  • short chain fatty acids 100%
  • digestive system 78%
  • B-lymphocytes 54%
  • inflammatory bowel disease 41%
  • metabolites 41%

• Pregnancy and Prenatal PAHs and other Environmental Exposures and Breast Cancer

  Terry, M. B. & Miller, R.

  National Institute of Environmental Health Sciences

  30/09/15 → 30/06/21

  Project: Research

  • Environmental Exposure 100%
  • Mothers 66%
  • Breast Neoplasms 64%
  • Pregnancy 59%
  • Polycyclic Aromatic Hydrocarbons 59%

• Mechanism of autoimmune hepatitis development in a novel mouse model

  Alexandropoulos, K.

  National Institute of Diabetes and Digestive and Kidney Diseases

  23/09/15 → 31/08/16

  Project: Research

  • Autoimmune Hepatitis 100%
  • Autoantigens 27%
  • T-Lymphocytes 27%
  • Liver 22%
  • Microbiota 18%

• Genetic Predisposition to Kawasaki Disease

  Byun, M.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  1/09/15 → 31/08/16

  Project: Research

• Sporadic Inclusion Body Mysoitis (sIBM)

  Byun, M.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  1/09/15 → 31/08/16

  Project: Research

• Pasinetti: Project 3; Role of Microbiome in Promotion of Cognitive and Psychological Resilience (Faith)

  Faith, J.

  National Center for Complementary and Integrative Health

  1/09/15 → 30/06/20

  Project: Research

  • microbiome 100%
  • phenolic acids 95%
  • bioavailability 89%
  • polyphenols 66%
  • intestinal microorganisms 46%

• Pasinetti: Overall; Dietary Botanicals in the Preservation of Cognitive and Psychological Resilience (Pasinetti)

  Pasinetti, G., Dixon, R. A., Faith, J., Ho, L., Russo, S. & Wang, J.

  National Center for Complementary and Integrative Health

  1/09/15 → 30/06/21

  Project: Research

  • polyphenols 100%
  • dietary supplements 51%
  • microbiome 37%
  • bioavailability 37%
  • career development 34%

• GLILD in CVID

  Routes, J. M., Bonilla, F. A., Cunningham-Rundles, C., Geha, R. S., Gundling, K. E., Kelly, M. E., Koth, L. L., Kovalszki, A., Rawlings, D. J., Simpson, P. M., Torgerson, T. R. & Verbsky, J. W.

  10/07/14 → 30/06/15

  Project: Research

  • Interstitial Lung Diseases 100%
  • Azathioprine 33%
  • Rituximab 32%
  • Common Variable Immunodeficiency 31%
  • Lung 24%

• Secondhand smoke and asthma: Mechanistic outcomes of DNA methylation in T cells

  Nadeau, K. C. & Miller, R.

  15/01/14 → 31/12/17

  Project: Research

  • Tobacco Smoke Pollution 100%
  • Asthma 87%
  • Eragrostis 51%
  • Methylation 22%
  • Epigenomics 16%

• T cell-derived iNOS switches off TH17 cell differentiation in inflammation

  Xiong, H.

  National Institute of Allergy and Infectious Diseases

  1/09/13 → 31/08/16

  Project: Research

  • Th17 Cells 100%
  • Cell Differentiation 64%
  • T-Lymphocytes 54%
  • Interleukin-17 50%
  • Inflammation 43%

• Airway Cellular and Cytokine Profiles in Older Patients with Asthma

  Busse, P.

  National Institute of Allergy and Infectious Diseases

  8/08/13 → 31/07/15

  Project: Research

  • Asthma 100%
  • Cytokines 59%
  • Interleukin-6 47%
  • Young Adult 37%
  • Regulatory T-Lymphocytes 30%

• Novel Mucosal Regulatory DC4+ T Cells: Interface Between Th17 and Treg

  Ting, A. & Mayer, L. F.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/09/12 → 31/08/16

  Project: Research

  • Regulatory T-Lymphocytes 100%
  • Th17 Cells 59%
  • Cues 32%
  • Rezafungin 24%
  • Ileitis 19%

• The Antigen Specificity of TH17 Cells to Pathogen and Epithelium

  Blander, J.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/09/12 → 31/08/16

  Project: Research

  • inflammatory bowel disease 100%
  • epithelium 45%
  • antigens 43%
  • interleukin-23 37%
  • pathogens 34%

• Role of Chemokines and IL-23 in the Biology of RORyt+ Cells

  Lira, S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/09/12 → 31/08/16

  Project: Research

  • Interleukin-23 100%
  • Chemokines 70%
  • Cell Biology 60%
  • Intestines 46%
  • Interleukin-23 Subunit p19 14%

• Animal Core

  Lira, S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/09/12 → 31/08/16

  Project: Research

  • animals 100%
  • colitis 92%
  • mice 76%
  • genetically modified organisms 50%
  • cost effectiveness 35%

• Control of protective immunity by innate pathways sensing bacterial viability

  Blander, J.

  National Institute of Allergy and Infectious Diseases

  15/08/12 → 31/07/16

  Project: Research

  • live vaccines 100%
  • immunity 63%
  • viability 59%
  • T-lymphocytes 51%
  • immune response 46%

• Mouse allergen intervention and DNA methylation of asthma regulatory genes

  Miller, R.

  National Institute of Allergy and Infectious Diseases

  1/07/12 → 30/06/13

  Project: Research

  • Allergens 100%
  • DNA Methylation 83%
  • Regulator Genes 81%
  • Asthma 80%
  • Pest Control 66%

• 2nd North American meeting by CIS devoted to primary immune deficiency.

  Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/03/12 → 28/02/13

  Project: Research

  • Allergy and Immunology 100%
  • Primary Immunodeficiency Diseases 96%
  • Organized Financing 35%
  • Congresses 19%
  • Competitive Bidding 17%

• Animal Core

  Lira, S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  23/09/11 → 31/08/12

  Project: Research

  • animals 100%
  • colitis 89%
  • mice 73%
  • genetically modified organisms 48%
  • cost effectiveness 34%

• The Antigen Specificity of TH17 Cells to Pathogen and Epithelium

  Blander, J.

  National Institute of Diabetes and Digestive and Kidney Diseases

  23/09/11 → 31/08/12

  Project: Research

  • inflammatory bowel disease 100%
  • antigens 35%
  • epithelium 34%
  • pathogens 27%
  • inflammation 25%

• Role of Chemokines and IL-23 in the Biology of RORyt+ Cells

  Lira, S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  23/09/11 → 31/08/12

  Project: Research

  • Interleukin-23 100%
  • Chemokines 60%
  • Intestines 50%
  • Cell Biology 44%
  • interleukin-22 12%

• Regulation of IgA class switching in the intestinal mucosa

  Cerutti, A.

  National Institute of Allergy and Infectious Diseases

  1/09/11 → 31/08/16

  Project: Research

  • Immunoglobulin Class Switching 100%
  • Immunoglobulin A 78%
  • Intestinal Mucosa 76%
  • B-Cell Activating Factor 65%
  • B-Lymphocytes 52%

• Silencing of Th17 cell differentiation by IRF8 in the development of colitis

  Xiong, H.

  National Institute of Allergy and Infectious Diseases

  1/09/11 → 31/12/12

  Project: Research

  • Th17 Cells 100%
  • Colitis 57%
  • Cell Differentiation 53%
  • Interleukin-17 31%
  • Th2 Cells 23%

• Molecular pathogenesis of intestinal serrated polyps

  Lira, S.

  National Cancer Institute

  1/09/11 → 31/07/21

  Project: Research

  • adenoma 100%
  • pathogenesis 80%
  • colorectal neoplasms 72%
  • lesions (animal) 43%
  • neoplasms 38%

• Administrative Core

  Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/09/11 → 31/08/16

  Project: Research

  • monitoring 100%
  • methodology 95%
  • tissues 52%
  • nurses 47%
  • physicians 43%

• Investigating Blocks to B Cell Memory in CVID

  Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/09/11 → 31/08/16

  Project: Research

  • Common Variable Immunodeficiency 100%
  • B-Lymphocytes 59%
  • Mutation 30%
  • Transmembrane Activator and CAML Interactor Protein 29%
  • Immunoglobulins 20%

• Patient Care Core

  Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/09/11 → 31/08/16

  Project: Research

  • Blood 100%
  • Testing 55%
  • Cells 52%

• Role of the thymic epithelium on the outcome of allogeneic transplantation

  Alexandropoulos, K.

  National Institute of Allergy and Infectious Diseases

  1/08/11 → 31/07/15

  Project: Research

  • Fibroblast Growth Factor 7 100%
  • Homologous Transplantation 87%
  • Epithelium 60%
  • Bone Marrow Transplantation 54%
  • T-Lymphocytes 50%

• Regulation and Function of Immunoglobulin D in Mucosal Immune Defense

  Cerutti, A.

  National Institute of Allergy and Infectious Diseases

  15/07/11 → 30/06/17

  Project: Research

  • Immunoglobulin D 100%
  • Respiratory Mucosa 14%
  • Mucosal Immunity 9%
  • Vaccination 8%
  • Cholecalciferol 8%

• B-cell Biology of Mucosal Immune Protection from SIV Challenge

  Hunter, E., Ahmed, R., Amara, R. R., Cerutti, A., Cooper, M. D., Derdeyn, C. A., Pulendran, B., Villinger, F. J., Wrammert, J. & Wrammert, J. P.

  7/07/11 → 30/06/17

  Project: Research

  • B-lymphocytes 100%
  • antibody affinity 46%
  • cell biology 35%
  • antibody formation 33%
  • nanoparticles 33%

• Dissecting The Interplay of GM-CSF and Neutrophils In IgG and IgA Responses

  Cerutti, A.

  National Institute of Allergy and Infectious Diseases

  7/07/11 → 30/06/16

  Project: Research

  • Granulocyte-Macrophage Colony-Stimulating Factor 100%
  • Immunoglobulin A 89%
  • B-Lymphocytes 73%
  • Immunoglobulin G 70%
  • Neutrophils 65%

• Regulation of V(D)J recombination by Rag2 C terminus

  Cortes, , P.

  National Institute of Allergy and Infectious Diseases

  20/05/10 → 31/10/15

  Project: Research

  • V(D)J Recombination 100%
  • Genetic Recombination 55%
  • Immune System 23%
  • PHD Zinc Fingers 20%
  • Minichromosome Maintenance Proteins 20%

• Resources to Assist Investigations in Primary Immunodeficiency Diseases (U24)

  Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/04/10 → 31/03/21

  Project: Research

  • Primary Immunodeficiency Diseases 100%
  • immunosuppression 68%
  • Registries 26%
  • cooperatives 18%
  • Physicians 16%