Icahn Genomics Institute

Icahn School of Medicine at Mount Sinai

Websitehttps://icahn.mssm.edu/research/genomics-institute

organization profile

The Icahn Genomics Institute (IGI) is dedicated to the development of new DNA and RNA based therapies. The success of the mRNA vaccines for treating COVID-19 has had a profound effect on the world—yet this is only the tip of the iceberg of gene medicine. The IGI is working on the next generation of advances in gene therapy, including identifying new genetic targets that drive disease, developing delivery mechanisms to modify or influence them, and pioneering treatments for diseases that have defied conventional treatment by traditional drugs. Our exploration of gene and cell therapy, RNA vaccines and therapeutics, and DNA-based drugs will have a profound effect on the way medicine is practiced.

Novel flu vaccines, regeneration of heart tissue following myocardial infarction, neoantigen vaccines to treat cancer—these are a few of the areas in which we are conducting groundbreaking research. Our researchers come from a range of disciplines and scientific focuses, including gene and cell engineering, CRISPR gene and base editing, RNA vaccines and therapeutics, viral oncolytics, microbiotics, regenerative medicine, as well as genomics, data science, and computational biology. With these tools, our scientists are working on improved treatments for cancer, infectious disease, inherited genetic disorders, neurodegeneration, heart disease and other conditions.

Housed within the Icahn School of Medicine at Mount Sinai, we are working together with physicians and physician scientists in the Mount Sinai Health System. From bench to clinical practice, we are leading the way in bringing the latest generation of gene and cell therapies to our patient population, including chimeric antigen receptor (CAR) T cell therapies and in situ vaccines for leukemia and multiple myeloma, and RNAi drugs for diseases such as acute intermittent porphyria, and other life-long genetic diseases. In doing so, we are helping to improve the lives of our patients and transforming medicine.

Our Research

325808 Citations
248 h-index
3323 Article
331 Review article
216 Comment/debate
91 Letter
More

5. Collaborative Study on the Genetics of Alcoholism: Functional genomics
COGA Collaborators, 2023, (Accepted/In press) In: Genes, Brain and Behavior.
Research output: Contribution to journal › Review article › peer-review

Open Access
1 Scopus citations
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, 1 Apr 2023, In: Nature. 616, 7958, p. 755-763 9 p.
Research output: Contribution to journal › Article › peer-review
4 Scopus citations
Acute systemic myeloid inflammatory and stress response in severe food allergic reactions
Sharma, A., Rijavec, M., Tomar, S., Yamani, A., Ganesan, V., Krempski, J., Schuler, C. F., Bunyavanich, S., Korosec, P. & Hogan, S. P., May 2023, In: Clinical and Experimental Allergy. 53, 5, p. 536-549 14 p.
Research output: Contribution to journal › Article › peer-review
Acyl-CoA dehydrogenase substrate promiscuity: Challenges and opportunities for development of substrate reduction therapy in disorders of valine and isoleucine metabolism
Houten, S. M., Dodatko, T., Dwyer, W., Violante, S., Chen, H., Stauffer, B., DeVita, R. J., Vaz, F. M., Cross, J. R., Yu, C. & Leandro, J., 2023, (Accepted/In press) In: Journal of Inherited Metabolic Disease.
Research output: Contribution to journal › Article › peer-review
A draft human pangenome reference
Liao, W. W., Asri, M., Ebler, J., Doerr, D., Haukness, M., Hickey, G., Lu, S., Lucas, J. K., Monlong, J., Abel, H. J., Buonaiuto, S., Chang, X. H., Cheng, H., Chu, J., Colonna, V., Eizenga, J. M., Feng, X., Fischer, C., Fulton, R. S., Garg, S., & 99 othersGroza, C., Guarracino, A., Harvey, W. T., Heumos, S., Howe, K., Jain, M., Lu, T. Y., Markello, C., Martin, F. J., Mitchell, M. W., Munson, K. M., Mwaniki, M. N., Novak, A. M., Olsen, H. E., Pesout, T., Porubsky, D., Prins, P., Sibbesen, J. A., Sirén, J., Tomlinson, C., Villani, F., Vollger, M. R., Antonacci-Fulton, L. L., Baid, G., Baker, C. A., Belyaeva, A., Billis, K., Carroll, A., Chang, P. C., Cody, S., Cook, D. E., Cook-Deegan, R. M., Cornejo, O. E., Diekhans, M., Ebert, P., Fairley, S., Fedrigo, O., Felsenfeld, A. L., Formenti, G., Frankish, A., Gao, Y., Garrison, N. A., Giron, C. G., Green, R. E., Haggerty, L., Hoekzema, K., Hourlier, T., Ji, H. P., Kenny, E. E., Koenig, B. A., Kolesnikov, A., Korbel, J. O., Kordosky, J., Koren, S., Lee, H. J., Lewis, A. P., Magalhães, H., Marco-Sola, S., Marijon, P., McCartney, A., McDaniel, J., Mountcastle, J., Nattestad, M., Nurk, S., Olson, N. D., Popejoy, A. B., Puiu, D., Rautiainen, M., Regier, A. A., Rhie, A., Sacco, S., Sanders, A. D., Schneider, V. A., Schultz, B. I., Shafin, K., Smith, M. W., Sofia, H. J., Abou Tayoun, A. N., Thibaud-Nissen, F., Tricomi, F. F., Wagner, J., Walenz, B., Wood, J. M. D., Zimin, A. V., Bourque, G., Chaisson, M. J. P., Flicek, P., Phillippy, A. M., Zook, J. M., Eichler, E. E., Haussler, D., Wang, T., Jarvis, E. D., Miga, K. H., Garrison, E., Marschall, T., Hall, I. M., Li, H. & Paten, B., 11 May 2023, In: Nature. 617, 7960, p. 312-324 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
32 Scopus citations
A foundational vision transformer improves diagnostic performance for electrocardiograms
Vaid, A., Jiang, J., Sawant, A., Lerakis, S., Argulian, E., Ahuja, Y., Lampert, J., Charney, A., Greenspan, H., Narula, J., Glicksberg, B. & Nadkarni, G. N., Dec 2023, In: npj Digital Medicine. 6, 1, 108.
Research output: Contribution to journal › Article › peer-review

Open Access
African ancestry GWAS of dementia in a large military cohort identifies significant risk loci
Sherva, R., Zhang, R., Sahelijo, N., Jun, G., Anglin, T., Chanfreau, C., Cho, K., Fonda, J. R., Gaziano, J. M., Harrington, K. M., Ho, Y. L., Kremen, W. S., Litkowski, E., Lynch, J., Neale, Z., Roussos, P., Marra, D., Mez, J., Miller, M. W., Salat, D. H., & 8 othersTsuang, D., Wolf, E., Zeng, Q., Panizzon, M. S., Merritt, V. C., Farrer, L. A., Hauger, R. L. & Logue, M. W., Mar 2023, In: Molecular Psychiatry. 28, 3, p. 1293-1302 10 p.
Research output: Contribution to journal › Article › peer-review
7 Scopus citations
AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review
Wang, B., Bonkovsky, H. L., Lim, J. K. & Balwani, M., Mar 2023, In: Gastroenterology. 164, 3, p. 484-491 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Scopus citations
Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons
Popova, D., Gameiro-Ros, I., Youssef, M. M., Zalamea, P., Morris, A. D., Prytkova, I., Jadali, A., Kwan, K. Y., Kamarajan, C., Salvatore, J. E., Xuei, X., Chorlian, D. B., Porjesz, B., Kuperman, S., Dick, D. M., Goate, A., Edenberg, H. J., Tischfield, J. A., Pang, Z. P., Slesinger, P. A., & 1 othersHart, R. P., Feb 2023, In: Molecular Psychiatry. 28, 2, p. 746-758 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
4 Scopus citations
Alterations in the cutaneous microbiome of patients with psoriasis and psoriatic arthritis reveal similarities between non-lesional and lesional skin
Boix-Amorós, A., Badri, M. H., Manasson, J., Blank, R. B., Haberman, R. H., Neimann, A. L., Girija, P. V., Jimenez Hernandez, A., Heguy, A., Koralov, S. B., Bonneau, R., Clemente, J. C. & Scher, J. U., 1 Apr 2023, In: Annals of the Rheumatic Diseases. 82, 4, p. 507-514 8 p.
Research output: Contribution to journal › Article › peer-review
4 Scopus citations
Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes
Inflammatory Arthritis Microbiome Consortium (IAMC) investigators group & IAMC, 26 Jul 2023, In: Science Translational Medicine. 15, 706, p. eabn4722
Research output: Contribution to journal › Article › peer-review
A machine learning model identifies patients in need of autoimmune disease testing using electronic health records
Forrest, I. S., Petrazzini, B. O., Duffy, Á., Park, J. K., O’Neal, A. J., Jordan, D. M., Rocheleau, G., Nadkarni, G. N., Cho, J. H., Blazer, A. D. & Do, R., Dec 2023, In: Nature Communications. 14, 1, 2385.
Research output: Contribution to journal › Article › peer-review

Open Access

Mount Sinai Reveals Asthma's Molecular Secrets in Blood
Supinda Bunyavanich
21/09/23
1 item of Media coverage
Press/Media
Proteomics-Based Assays To Enable Precision Medicine For Ovarian Cancer
Pei Wang
21/09/23
1 item of Media coverage
Press/Media
Unveiling Asthma's Molecular Secrets: How Blood Molecules Influence Airway Processes
Supinda Bunyavanich
20/09/23
2 items of Media coverage
Press/Media
New Gene Therapy Study Findings Reported from Icahn School of Medicine at Mount Sinai (Acid Ceramidase Gene Therapy Ameliorates Pulmonary Arterial Hypertension With Right Heart Dysfunction)
Efrat Eliyahu, Peter Pastuszko & Michael Katz
19/09/23
1 item of Media coverage
Press/Media
Reports on Melanoma from Icahn School of Medicine at Mount Sinai Provide New Insights (Macroh2a Restricts Inflammatory Gene Expression In Melanoma Cancer-associated Fibroblasts By Coordinating Chromatin Looping)
Dan Filipescu, Miriam Merad, Nikki Vyas, Robert Sebra, Emily Bernstein, Matthew Goldberg, Helene Salmon & Alice O. Kamphorst
19/09/23
1 item of Media coverage
Press/Media
Findings from Icahn School of Medicine at Mount Sinai Update Understanding of Multiple Sclerosis (Interleukin-3 Coordinates Glial-peripheral Immune Crosstalk To Incite Multiple Sclerosis)
Vladimir Roudko, Seunghee Kim-Schulze, Panagiotis Roussos, Achillefs Ntranos, John Fullard, Cameron McAlpine, Donghoon Lee & Filip Swirski
14/09/23
1 item of Media coverage
Press/Media
Icahn School of Medicine at Mount Sinai Reports Findings in Genomics and Genetics (Generation of Host-directed and Virus-specific Antivirals Using Targeted Protein Degradation Promoted By Small Molecules and Viral Rna Mimics)
Nan Zhao, Jian Jin, Ivan Marazzi, Jeffrey Johnson & Domenico Tortorella
13/09/23
1 item of Media coverage
Press/Media
Studies from Icahn School of Medicine at Mount Sinai Yield New Data on Vaccines (Modified mRNA Formulation and Stability for Cardiac and Skeletal Muscle Delivery)
Lior Zangi
13/09/23
1 item of Media coverage
Press/Media
University of Alabama: A Modified MRNA Aids Heart Attack Recovery in Mouse and Pig Models
Lior Zangi
13/09/23
1 item of Media coverage
Press/Media
New Binge Eating Disorder Study Findings Have Been Reported from Icahn School of Medicine at Mount Sinai (Genome-wide Analysis of a Model-derived Binge Eating Disorder Phenotype Identifies Risk Loci and Implicates Iron Metabolism)
Sanan Venkatesh, Biao Zeng, Tom Hildebrandt, Geogios Voloudakis, Robyn Sysko, Panagiotis Roussos, Amirhossein Modabbernia & Gabriel Hoffman
12/09/23
1 item of Media coverage
Press/Media
Research Reports from Icahn School of Medicine at Mount Sinai Provide New Insights into Spinal Cord Injury (Spinal cord injury regulates circular RNA expression in axons)
Jens Hansen, Robert Sebra & Srinivas (Ravi) Iyengar
11/09/23
1 item of Media coverage
Press/Media
A modified mRNA aids heart attack recovery in mouse and pig models
Lior Zangi
11/09/23
1 item of Media coverage
Press/Media

Icahn Genomics Institute

Organization profile

organization profile

Our Research

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