Projects per year
Organization profile
The Icahn Genomics Institute (IGI) is dedicated to the development of new DNA and RNA based therapies. The success of the mRNA vaccines for treating COVID-19 has had a profound effect on the world—yet this is only the tip of the iceberg of gene medicine. The IGI is working on the next generation of advances in gene therapy, including identifying new genetic targets that drive disease, developing delivery mechanisms to modify or influence them, and pioneering treatments for diseases that have defied conventional treatment by traditional drugs. Our exploration of gene and cell therapy, RNA vaccines and therapeutics, and DNA-based drugs will have a profound effect on the way medicine is practiced.
Novel flu vaccines, regeneration of heart tissue following myocardial infarction, neoantigen vaccines to treat cancer—these are a few of the areas in which we are conducting groundbreaking research. Our researchers come from a range of disciplines and scientific focuses, including gene and cell engineering, CRISPR gene and base editing, RNA vaccines and therapeutics, viral oncolytics, microbiotics, regenerative medicine, as well as genomics, data science, and computational biology. With these tools, our scientists are working on improved treatments for cancer, infectious disease, inherited genetic disorders, neurodegeneration, heart disease and other conditions.
Housed within the Icahn School of Medicine at Mount Sinai, we are working together with physicians and physician scientists in the Mount Sinai Health System. From bench to clinical practice, we are leading the way in bringing the latest generation of gene and cell therapies to our patient population, including chimeric antigen receptor (CAR) T cell therapies and in situ vaccines for leukemia and multiple myeloma, and RNAi drugs for diseases such as acute intermittent porphyria, and other life-long genetic diseases. In doing so, we are helping to improve the lives of our patients and transforming medicine.
Our Research
Fingerprint
Network
Profiles
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Dusan Bogunovic
- Center for Inborn Errors of Immunity
- Department of Pediatrics Research
- Genetics and Genomic Sciences
- Icahn Genomics Institute
- Icahn School of Medicine at Mount Sinai
- Marc and Jennifer Lipschultz Precision Immunology Institute
- Microbiology
- Mindich Child Health and Development Institute
- Oncological Sciences
- Pediatrics
Person
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Brian Brown
- Cancer Immunology
- Center for Inborn Errors of Immunity
- Friedman Brain Institute
- Genetics and Genomic Sciences
- Icahn Genomics Institute
- Icahn School of Medicine at Mount Sinai
- Marc and Jennifer Lipschultz Precision Immunology Institute
- Mindich Child Health and Development Institute
- The Tisch Cancer Institute
Person
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Supinda Bunyavanich
- Department of Pediatrics Research
- Elliot and Roslyn Jaffe Food Allergy Institute
- Environmental Medicine and Public Health
- Friedman Brain Institute
- Genetics and Genomic Sciences
- Icahn Genomics Institute
- Icahn School of Medicine at Mount Sinai
- Institute for Exposomic Research
- Mindich Child Health and Development Institute
- Pediatrics
Person
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Alexander Charney
- Artificial Intelligence and Human Health
- Depression and Anxiety Center
- Friedman Brain Institute
- Genetics and Genomic Sciences
- Hasso Plattner Institute for Digital Health at Mount Sinai
- Icahn Genomics Institute
- Icahn School of Medicine at Mount Sinai
- Jeff and Lisa Blau Adolescent Consultation Center for Resilience and Treatment
- Mount Sinai Clinical Intelligence Institute
- Pamela Sklar Division of Psychiatric Genomics
- Psychiatry
Person
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Judy Cho
- Artificial Intelligence and Human Health
- Cancer Prevention & Control
- Friedman Brain Institute
- Genetics and Genomic Sciences
- Icahn Genomics Institute
- Icahn School of Medicine at Mount Sinai
- Medicine
- Medicine - Gastroenterology
- Marc and Jennifer Lipschultz Precision Immunology Institute
- The Charles Bronfman Institute for Personalized Medicine
- The Tisch Cancer Institute
Person
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Dissect regulation of glial nets surrounding amyloid plaques in Alzheimer's disease
Friedel, R., Wang, M. & Zou, H.
5/05/22 → 30/04/25
Project: Research
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Neuroprotective signaling and transcriptional pathways in microglia associated with Alzheimer's disease
Goate, A., Schaefer, A. & Schaefer, A. A.
1/02/22 → 30/11/23
Project: Research
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A deep longitudinal analysis of next generation influenza vaccines in older adults
Garcia-Sastre, A., Garcia-sastre, A. A. & Kuchel, G. G. A.
National Institute of Allergy and Infectious Diseases
1/01/22 → 31/12/23
Project: Research
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Elucidating the Molecular Mechanisms that Mediate DKD Progression in Patients Living with HIV
He, J. J. C. & Ma’ayan, A.
National Institute of Diabetes and Digestive and Kidney Diseases
1/12/21 → 30/11/23
Project: Research
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Molecular and Cellular Basis of the Gut-Brain Axis in Parkinsons Disease
Yue, Z. Z., Han, W., Peter, I., Peter, I., Saunders-pullman, R. R., Saunders-Pullman, R., Han, W. W. & Yue, Z.
National Institute of Neurological Disorders and Stroke
15/09/21 → 31/08/23
Project: Research
Research output
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AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review
Wang, B., Bonkovsky, H. L., Lim, J. K. & Balwani, M., 2023, (Accepted/In press) In: Gastroenterology.Research output: Contribution to journal › Article › peer-review
Open Access -
An atlas of substrate specificities for the human serine/threonine kinome
Johnson, J. L., Yaron, T. M., Huntsman, E. M., Kerelsky, A., Song, J., Regev, A., Lin, T. Y., Liberatore, K., Cizin, D. M., Cohen, B. M., Vasan, N., Ma, Y., Krismer, K., Robles, J. T., van de Kooij, B., van Vlimmeren, A. E., Andrée-Busch, N., Käufer, N. F., Dorovkov, M. V., Ryazanov, A. G., & 20 others , 2023, (Accepted/In press) In: Nature.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Bridging advanced myeloma patients to subsequent treatments and clinical trials with classical chemotherapy and stem cell support
Mouhieddine, T. H., Moshier, E., Thibaud, S., Puliafito, B., Rattu, M., Jakubowski, R., Sanchez, L., Rossi, A., Rodriguez, C., Richard, S., Cho, H. J., Parekh, S., Chari, A., Steinberg, A. & Richter, J., Jan 2023, In: Bone Marrow Transplantation. 58, 1, p. 80-86 7 p.Research output: Contribution to journal › Article › peer-review
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Comorbidity and healthcare utilization in patients with treatment resistant depression: A large-scale retrospective cohort analysis using electronic health records
Adekkanattu, P., Olfson, M., Susser, L. C., Patra, B., Vekaria, V., Coombes, B. J., Lepow, L., Fennessy, B., Charney, A., Ryu, E., Miller, K. D., Pan, L., Yangchen, T., Talati, A., Wickramaratne, P., Weissman, M., Mann, J., Biernacka, J. M. & Pathak, J., 1 Mar 2023, In: Journal of Affective Disorders. 324, p. 102-113 12 p.Research output: Contribution to journal › Article › peer-review
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Erratum: Publisher Correction: A pipeline for malignancy and therapy agnostic assessment of cancer drug response using cell mass measurements (Communications biology (2022) 5 1 (1295))
Kimmerling, R. J., Stevens, M. M., Olcum, S., Minnah, A., Vacha, M., LaBella, R., Ferri, M., Wasserman, S. C., Fujii, J., Shaheen, Z., Sundaresan, S., Ribadeneyra, D., Jayabalan, D. S., Agte, S., Aleman, A., Criscitiello, J. A., Niesvizky, R., Luskin, M. R., Parekh, S., Rosenbaum, C. A., & 2 others , 6 Jan 2023, In: Communications Biology. 6, 1, p. 15 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Evaluation and validation of an RT-PCR assay for specific detection of monkeypox virus (MPXV)
Paniz-Mondolfi, A., Guerra, S., Muñoz, M., Luna, N., Hernandez, M. M., Patino, L. H., Reidy, J., Banu, R., Shrestha, P., Liggayu, B., Umeaku, A., Chen, F., Cao, L., Patel, A., Hanna, A., Li, S., Look, A., Pagani, N., Albrecht, R., Pearl, R., & 24 others , Jan 2023, In: Journal of Medical Virology. 95, 1, e28247.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
FAVOR: functional annotation of variants online resource and annotator for variation across the human genome
NHGRI Genome Sequencing Program Variant Functional Annotation Working Group, 6 Jan 2023, In: Nucleic Acids Research. 51, D1, p. D1300-D1311Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness
Clinical Proteomic Tumor Analysis Consortium, 9 Jan 2023, In: Cancer Cell. 41, 1, p. 139-163.e17Research output: Contribution to journal › Article › peer-review
Open Access -
Large 22q13.3 deletions perturb peripheral transcriptomic and metabolomic profiles in Phelan-McDermid syndrome
the Developmental Synaptopathies Consortium, 12 Jan 2023, In: Human Genetics and Genomics Advances. 4, 1, 100145.Research output: Contribution to journal › Article › peer-review
Open Access -
Navigating the pitfalls of mapping DNA and RNA modifications
Kong, Y., Mead, E. A. & Fang, G., 2023, (Accepted/In press) In: Nature Reviews Genetics.Research output: Contribution to journal › Review article › peer-review
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SCLC: Epidemiology, Risk Factors, Genetic Susceptibility, Molecular Pathology, Screening, and Early Detection
Wang, Q., Gümüş, Z. H., Colarossi, C., Memeo, L., Wang, X., Kong, C. Y. & Boffetta, P., Jan 2023, In: Journal of Thoracic Oncology. 18, 1, p. 31-46 16 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Selecting Clustering Algorithms for Identity-By-Descent Mapping
Shemirani, R., Belbin, G. M., Burghardt, K., Lerman, K., Avery, C. L., Kenny, E. E., Gignoux, C. R. & Ambite, J. L., 2023, In: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 2023, p. 121-132 12 p.Research output: Contribution to journal › Conference article › peer-review
Open Access
Press / Media
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Inflammation and Immunity Troubles Top Long COVID Suspect List
1/02/23 → 2/02/23
2 items of Media coverage
Press/Media
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Inflammation and immunity issues top long COVID suspect list
1/02/23
1 item of Media coverage
Press/Media
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Cancer vaccines: Can the disease be treated with an injection?
1/02/23
1 item of Media coverage
Press/Media
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New Findings on Life Science from Icahn School of Medicine at Mount Sinai Summarized (Human Gut Microbiota Stimulate Defined Innate Immune Responses That Vary From Phylum To Strain)
Graham Britton, Ilaria Mogno, Jeremiah Faith & Saurabh Mehandru
31/01/23
1 item of Media coverage
Press/Media
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Cell BioEngines Enters into Licensing Agreement with Icahn School of Medicine at Mount Sinai
Sreekumar Balanalan, Sreekumar Balan & Nina Bhardwaj
27/01/23
1 item of Media coverage
Press/Media
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Mount Sinai Researchers Awarded $12 Million NIH Grant To Create A Center To Unravel Novel Causes Of Food Allergy And Atopic Dermatitis
27/01/23
1 item of Media coverage
Press/Media
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Mount Sinai Researchers Awarded $12 Million NIH Grant to Create a Center to Unravel Novel Causes of Food Allergy & Atopic Dermatitis That Uses a Systems Biology Approach
25/01/23 → 26/01/23
21 items of Media coverage
Press/Media
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Cell BioEngines Enters into an Exclusive Worldwide Agreement to Develop and Commercialize Potent Immune Cell States to Cure Cancer
Sreekumar Balanalan, Sreekumar Balan & Nina Bhardwaj
25/01/23 → 26/01/23
93 items of Media coverage
Press/Media
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Studies in the Area of Lyme Disease Reported from Icahn School of Medicine at Mount Sinai (Gene Set Predictor for Post-treatment Lyme Disease)
25/01/23
1 item of Media coverage
Press/Media