The Department of Genetics and Genomic Sciences leverages a legacy of excellence, a team of world-class geneticists and researchers, and access to one-of-a-kind resources and collaborations to bring pioneering ideas to life.

The Department ranked #2 in the country in NIH funding in genetics research in 2021 with specialty research programs including rare and metabolic diseases, cancer genomics, genomics of neurodegenerative and neuropsychiatric diseases, experimental and AI approaches to drug discovery, functional genomics, single cell sequencing, experimental biology, immunogenomics, microbiome, and genomics of infectious diseases. The Department’s faculty is composed of basic and translational research scientists, data scientists, technology innovators, and experts in key diseases working together with the shared goal of leveraging large-scale data, coupled with applications of advanced multi-omics technologies, to predict, test, and translate novel therapies faster and more effectively.

Patient Care

We are home to the Division of Medical Genetics and Genomics, a National Organization for Rare Diseases Center of Excellence, specializing in the screening, diagnosis, and treatment of adult and pediatric patients with or suspected of having genetic diseases, birth defects, reproductive complications, or cancer risks. The Division offers 12 specialty programs and clinics and is highly engaged in training the next generation of genetics and genomics professionals through its residency and fellowship programs. The Division’s home within the Department of Genetics and Genomic Sciences and collaborations throughout the Mount Sinai Health System helps medical faculty and physician scientists provide patients access to cutting-edge research that will shed light on how genetic and genomic variation contributes to human disease and bring hope for new treatment options to patients.

Clinical Trials

The Department’s faculty has a substantial history of translational work and conducting clinical trials for patients with rare genetic disorders and has a dedicated Genetics Clinical Trials Office. To date, the department has performed more than 50 industry, National Institutes of Health, and investigator-initiated studies including groundbreaking DNA, RNA, and enzyme-based therapies.

Education and Training

The Department’s extensive education and training programs include a PhD concentration in Genetics and Genomic Sciences, a Masters of Science program in Genetic Counseling, Clinical and Research Training Fellowships in Medical Genetics, a Clinical Genetics Laboratory Training Program, and two T32 training grants.