Center for Inborn Errors of Immunity

Projects

Projects per year 1984 2011 2017 2021 2024

• 11 Active
• 37 Finished

Projects per year

Search results

• Active

  Altered inflammatory response associated with acquired DNMT3A mutations

  Byun, M. & Byun, M.

  National Heart, Lung, and Blood Institute

  1/05/21 → 30/04/23

  Project: Research

  • Myeloid Cells 100%
  • Mutation 97%
  • Macrophages 54%
  • Blood Cells 48%
  • Pluripotent Stem Cells 45%

• Investigating the Role of Age, Race and Ethnicity in Response to Immunomodulating Agents in Children with Moderate to Severe Atopic Dermatitis

  Pagan, A. A. & Guttman, E.

  Pediatric Dermatology Research Alliance

  1/01/21 → …

  Project: Research

  • Atopic Dermatitis 100%
  • dupilumab 77%
  • Child 41%
  • Interleukin-17 23%
  • Incidence 21%

• Next Generation Resolution of Antiviral Gene Networks

  Bogunovic, D., Bogunovic, D., Rosenberg, B. & Rosenberg, B.

  National Institute of Allergy and Infectious Diseases

  22/09/20 → 31/08/23

  Project: Research

  • Gene Regulatory Networks 100%
  • Antiviral Agents 98%
  • Interferons 52%
  • Genes 42%
  • Viruses 34%

• Inborn Errors of Immunity Leading to Autoinflammatory Syndromes

  Bogunovic, D. & Bogunovic, D.

  National Institute of Allergy and Infectious Diseases

  1/07/20 → 30/06/23

  Project: Research

  • Interferons 100%
  • Immunity 75%
  • Cytokines 37%
  • Nervous System 32%
  • Genes 32%

• Cancer Research Institute Grants

  Brown, B.

  Cancer Research Institute

  1/01/20 → …

  Project: Research

  • Organized Financing 100%
  • Neoplasms 50%
  • Technology 24%
  • Immunotherapy 22%
  • Immunosuppressive Agents 21%

• Type I Interferon Dysregulation in Down Syndrome

  Bogunovic, D.

  National Institute of Allergy and Infectious Diseases

  16/09/19 → 31/03/24

  Project: Research

  • Down Syndrome 100%
  • Interferon Type I 66%
  • Severe Acute Respiratory Syndrome 30%
  • Gene Dosage 22%
  • Interferon alpha-beta Receptor 16%

• Cancer Research Institute Grants

  Brown, B.

  Cancer Research Institute

  1/01/19 → …

  Project: Research

  • Organized Financing 100%
  • Neoplasms 50%
  • Technology 24%
  • Immunotherapy 22%
  • Immunosuppressive Agents 21%

• Human ISG15 and USP18 Deficiencies Underlying Type I Interferonopathies

  Bogunovic, D. & Bogunovic, D.

  National Institute of Allergy and Infectious Diseases

  9/06/17 → 31/05/23

  Project: Research

  • Interferons 100%
  • Interferon Type I 58%
  • Spondyloenchondrodysplasia 56%
  • Virus Diseases 52%
  • Antiviral Agents 37%

• International Eczema Council

  Guttman, E. & Paller, A. A.

  LEO Fondet

  1/01/16 → …

  Project: Research

  • treatment decisions 100%
  • decision making 45%

• Deciphering non-coding RNA regulatory networks and their role in cancer cell biology

  Rajewsky, N. N., Bozzoni, I. I., Pandolfi, P. P. P. P. & Brown, B.

  Human Frontier Science Program

  1/01/14 → …

  Project: Research

  • Untranslated RNA 100%
  • Cell Biology 48%
  • MicroRNAs 29%
  • Neoplasms 19%
  • Molecular Computers 19%

• Development of a DNA Vaccine for Inducing Tolerance and Preventing Diabetes

  Brown, B.

  Juvenile Diabetes Research Foundation United States of America

  1/12/08 → …

  Project: Research

  • Type 1 Diabetes Mellitus 100%
  • DNA Vaccines 81%
  • Insulin 76%
  • Vaccines 67%
  • Immune System 53%
• Finished

  Mechanistic modeling of epigenetic modifier mutations in human pluripotent stem cell-derived immune cells

  Byun, M.

  National Institute of Allergy and Infectious Diseases

  1/02/22 → 31/01/23

  Project: Research

  • Pluripotent Stem Cells 100%
  • Epigenomics 74%
  • Mutation 63%
  • Hematologic Diseases 49%
  • Hematologic Neoplasms 43%

• Transient Gene Therapy as Broad Spectrum Antiviral

  Bogunovic, D.

  National Institute of Allergy and Infectious Diseases

  1/09/21 → 31/08/22

  Project: Research

  • Influenza A virus 100%
  • SARS Virus 95%
  • Antiviral Agents 66%
  • Genetic Therapy 48%
  • Cricetinae 39%

• Investigating Macrophage Molecular and Functional Diversity in Tumor Immunity

  Merad, M., Brown, B., Brown, B. B. D. & Merad, M.

  National Cancer Institute

  1/02/21 → 31/01/23

  Project: Research

  • Immunity 100%
  • Macrophages 96%
  • Immunotherapy 72%
  • Lung Neoplasms 62%
  • Neoplasms 44%

• Deciphering the molecular control of intratumoral dendritic cells

  Merad, M., Brown, B., Brown, B. B. D. & Merad, M.

  National Cancer Institute

  1/02/21 → 31/01/23

  Project: Research

  • Dendritic Cells 100%
  • Immunity 36%
  • Neoplasms 21%
  • Antigens 19%
  • Genes 16%

• Cellular and molecular characterization of LIG1 mutations causing a spectrum of primary immune deficiencies

  O’Brien, P. J. & Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  19/06/19 → 31/05/21

  Project: Research

  • Primary Immunodeficiency Diseases 100%
  • DNA Replication 73%
  • Alleles 53%
  • Ligases 53%
  • Mutation 44%

• Develop functional screening and genetic diagnosis for inborn errors in the NF-kappaB pathways

  Guennoun, A. A., Marr, N. N., Fuleihan, R. R., Lo, B. B., Cunningham-Rundles, C., Casanova, J. J. & Zhang, Q. Q.

  Qatar National Research Fund

  15/06/18 → 14/04/22

  Project: Research

  • Primary Immunodeficiency Diseases 100%
  • Genetic Testing 44%
  • NF-kappa B 42%
  • Qatar 29%
  • Mutation 22%

• Harnessing NK cell effector function for immunotherapies

  Horowitz, A.

  National Institute of Allergy and Infectious Diseases

  18/08/17 → 31/07/19

  Project: Research

  • Natural Killer Cells 100%
  • Immunotherapy 65%
  • Immune System 27%
  • Cytokines 26%
  • HLA-A Antigens 26%

• ZIKA VIRUS RESISTANCE; HOST DETERMINANTS

  Bogunovic, D.

  National Institute of Allergy and Infectious Diseases

  5/08/17 → 31/07/19

  Project: Research

  • Zika Virus 100%
  • Zika Virus Infection 67%
  • Interferons 33%
  • Preliminary Data 26%
  • Central America 16%

• Interplay between Negative Regulators of Type I Interferon and HIV control

  Bogunovic, D. & Simon, V.

  National Institute of Allergy and Infectious Diseases

  10/06/17 → 31/05/19

  Project: Research

  • Interferon Type I 100%
  • Interferons 98%
  • HIV 77%
  • Antiviral Agents 26%
  • Germ-Line Mutation 17%

• Blocks to B Cell Memory

  Cunningham-Rundles, C. & Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/05/17 → 31/07/22

  Project: Research

  • B-Lymphocytes 100%
  • Common Variable Immunodeficiency 80%
  • Plasma Cells 28%
  • Autoimmunity 28%
  • Transmembrane Activator and CAML Interactor Protein 27%

• Patient Core

  Cunningham-Rundles, C. & Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/05/17 → 31/07/22

  Project: Research

  • Research Ethics Committees 100%
  • Ambulatory Care 94%
  • Confidentiality 57%
  • Research Personnel 49%
  • Patient Selection 41%

• Administrative Core

  Cunningham-Rundles, C. & Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/05/17 → 31/07/22

  Project: Research

  • Research Personnel 100%
  • Direction compound 17%

• Genetic Predisposition to Kawasaki Disease

  Byun, M.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  1/09/15 → 31/08/16

  Project: Research

• Sporadic Inclusion Body Mysoitis (sIBM)

  Byun, M.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  1/09/15 → 31/08/16

  Project: Research

• GLILD in CVID

  Routes, J. M., Bonilla, F. A., Cunningham-Rundles, C., Geha, R. S., Gundling, K. E., Kelly, M. E., Koth, L. L., Kovalszki, A., Rawlings, D. J., Simpson, P. M., Torgerson, T. R. & Verbsky, J. W.

  10/07/14 → 30/06/15

  Project: Research

  • Interstitial Lung Diseases 100%
  • Azathioprine 33%
  • Rituximab 32%
  • Common Variable Immunodeficiency 31%
  • Lung 24%

• ISG15 responsive pathway

  Bogunovic, D.

  National Institute of Allergy and Infectious Diseases

  15/03/14 → 29/02/16

  Project: Research

  • Interferons 100%
  • Natural Killer Cells 67%
  • Mutation 30%
  • Immunity 29%
  • Genes 29%

• Immune profiling by high throughput sequencing of complete antigen receptors

  Rosenberg, B. & Rosenberg, B.

  NIH Office of the Director

  25/09/12 → 31/08/18

  Project: Research

  • antigens 100%
  • receptors 93%
  • T-lymphocytes 59%
  • adaptive immunity 53%
  • B-lymphocytes 49%

• 2nd North American meeting by CIS devoted to primary immune deficiency.

  Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/03/12 → 28/02/13

  Project: Research

  • Allergy and Immunology 100%
  • Primary Immunodeficiency Diseases 96%
  • Organized Financing 35%
  • Congresses 19%
  • Competitive Bidding 17%

• Investigating Blocks to B Cell Memory in CVID

  Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/09/11 → 31/08/16

  Project: Research

  • Common Variable Immunodeficiency 100%
  • B-Lymphocytes 59%
  • Mutation 30%
  • Transmembrane Activator and CAML Interactor Protein 29%
  • Immunoglobulins 20%

• Administrative Core

  Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/09/11 → 31/08/16

  Project: Research

  • monitoring 100%
  • methodology 95%
  • tissues 52%
  • nurses 47%
  • physicians 43%

• Patient Care Core

  Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/09/11 → 31/08/16

  Project: Research

  • Blood 100%
  • Testing 55%
  • Cells 52%

• Genome-wide investigation of inborn errors of immunity to human infectious diseases on the individual and population levels

  Itan, Y.

  AXA Research Fund

  1/01/11 → 31/12/12

  Project: Research

  • Communicable Diseases 100%
  • Immunity 76%
  • Genome 63%
  • Population 54%
  • Genetic Background 49%

• Exploiting microRNA regulation to induce tolerance

  Brown, B.

  Juvenile Diabetes Research Foundation United States of America

  1/08/10 → 31/07/12

  Project: Research

  • insulin 100%
  • immune system 72%
  • microRNA 64%
  • insulin-dependent diabetes mellitus 55%
  • diabetes 40%

• CIS First North American Primary Immune Deficiency National Conference

  Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/04/10 → 31/03/11

  Project: Research

  • Primary Immunodeficiency Diseases 100%
  • Allergy and Immunology 96%
  • Organized Financing 42%
  • Posters 30%
  • Congresses 23%

• Resources to Assist Investigations in Primary Immunodeficiency Diseases (U24)

  Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/04/10 → 31/03/21

  Project: Research

  • Primary Immunodeficiency Diseases 100%
  • immunosuppression 68%
  • Registries 26%
  • cooperatives 18%
  • Physicians 16%

• Primary Immunodeficiency Diseases Consortium Conference

  Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  9/03/09 → 8/03/10

  Project: Research

  • expert 100%
  • grant 98%
  • federation 78%
  • travel 69%
  • networking 67%

• Primary Immune Deficiency Consortium Conference

  Cunningham-Rundles, C. & Cunningham-rundles, C. C.

  National Institute of Allergy and Infectious Diseases

  15/03/06 → 28/02/09

  Project: Research

  • Primary Immunodeficiency Diseases 100%
  • Congresses 77%
  • Allergy and Immunology 66%
  • Research Personnel 54%
  • Organized Financing 36%

• Primary Immunne Deficiency Consortium Conference

  Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/03/05 → 28/02/06

  Project: Research

  • Allergy and Immunology 100%
  • Primary Immunodeficiency Diseases 96%
  • Research Personnel 81%
  • Congresses 69%
  • Organized Financing 55%

• Investigating Blocks to B Cell Memory in CVID

  Cunningham-Rundles, C. & Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  15/09/04 → 28/02/09

  Project: Research

  • Common Variable Immunodeficiency 100%
  • B-Lymphocytes 72%
  • Chemokines 18%
  • Psychology Retention 14%
  • Toll-Like Receptors 14%

• Cellular and Molecular Defects in Human B Cell Development

  Cunningham-Rundles, C., Cerutti, A., Casanova, J. L., Cerutti, A., Cunningham-Rundles, C., Meffre, E. E., Furtado, G., Diaz, G., Furtado, G. G. C., Casanova, J. J., Mayer, L. L. F., Mayer, L. F., Meffre, E., Cortes, , P., Cortes, P. & Diaz, G. A.

  National Institute of Allergy and Infectious Diseases

  15/09/04 → 31/07/22

  Project: Research

  • B-Lymphocytes 100%
  • Primary Immunodeficiency Diseases 56%
  • Common Variable Immunodeficiency 32%
  • Allergy and Immunology 27%
  • Research Personnel 16%

• CORE--Patient Acquisition

  Cunningham-Rundles, C. & Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  15/09/04 → 28/02/09

  Project: Research

  • Consent Forms 100%
  • Research Ethics Committees 77%
  • Patient Care 28%
  • Parents 27%

• 2003 CIS Summer School

  Cunningham-Rundles, C.

  National Institute of Environmental Health Sciences

  24/09/03 → 31/08/04

  Project: Research

  • Allergy and Immunology 100%
  • Primary Immunodeficiency Diseases 92%
  • Organized Financing 59%
  • Students 23%
  • Central America 23%

• 2002 Summer School in Primary Immunodeficiency Disorders

  Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  1/06/02 → 31/05/03

  Project: Research

  • travel 100%
  • honorarium 98%
  • goal of education 77%
  • allergy 75%
  • Central America 68%

• Rheumatic Diseases Core Center

  Yokoyama, W. M., Atkinson, J., Atkinson, J. P., Bhattacharya, D., Hsieh, C. C. S., Weihl, C. C. C., Lenschow, D. D. J., Shih, F. F. F., Atkinson, J. J., Atkinson, J. J. P., Lenschow, D. J., Cooper, M. M. A., Artomov, M. M., Byun, M., Novak, D. J., Pham, C. T., Schreiber, R. R. D., Schreiber, R. D., Shaw, A. S., Shih, F. F., Vig, M. & Yokoyama, W. W. M.

  28/09/01 → 31/08/16

  Project: Research

  • translational medical research 100%
  • disease models 86%
  • leadership 83%
  • hybridomas 76%
  • funding 71%

• Targeting Primary Immune Deficiency in Patient Populations

  Cunningham-Rundles, C. & Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  30/09/00 → 31/05/10

  Project: Research

  • Primary Immunodeficiency Diseases 100%
  • Urban Hospitals 35%
  • Hispanic Americans 30%
  • Population 27%
  • Diagnostic Services 25%

• MECHANISMS OF IL-2 IMMUNE ENHANCEMENT IN HUMANS

  Cunningham-Rundles, C.

  National Institute of Allergy and Infectious Diseases

  30/09/99 → 31/08/03

  Project: Research

  • Interleukin-2 100%
  • T-Lymphocytes 52%
  • Common Variable Immunodeficiency 35%
  • Immunity 27%
  • Cytokines 21%

• CORE--IMMUNOLOGY LABORATORY

  Cunningham-Rundles, C., Cunningham-rundles, S. & Cunningham-rundles, S. S.

  National Cancer Institute

  1/10/84 → 30/09/00

  Project: Research