Center for Inborn Errors of Immunity

Icahn School of Medicine at Mount Sinai

99893 Citations
161 h-index
846 Article
146 Review article
57 Letter
56 Comment/debate
More

Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure
Koenen, M., Becher, T., Pagano, G., Gaudio, I. D., Barrero, J. A., Montezano, A. C., Ortiz, J. R., Lin, Z., Gómez-Banoy, N., Amblard, R., Schriever, D., Kars, M. E., Rubinelli, L., Halix, S. J., Cao, Z. F. H., Zeng, X., Butler, S. D., Itan, Y., Touyz, R. M. & Lorenzo, A. D. & 1 others, Cohen, P., 15 Jan 2026, In: Science. 391, 6782, p. 306-313 8 p.
Research output: Contribution to journal › Article › peer-review
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth
Mateus-Tique, J., Lakshmi, A., Singh, B., Iyer, R., Sánchez-Paulete, A. R., Falcomatà, C., Lin, M., Pantsulaia, G., Tepper, A., Nguyen, T., Amabile, A., Mollaoglu, G., Pia, L., Chhamalwan, D., Le Berichel, J., Potak, H., Colonna, M., Baccarini, A., Brody, J. & Merad, M. & 1 others, Brown, B. D., 2026, (Accepted/In press) In: Cancer Cell.
Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Clinical and Molecular Effect of the Anti–IL-18 Antibody Aletekitug in Adults With Atopic Dermatitis
Ellis, J., Fortunato, L., Wajdner, H., Del Duca, E., Barnard, J., Betts, J. C., Bose, S., Browning, J., Buil-Bruna, N., Van Buren, S., David, E., Dinehart, S., Dhawan, P., Estrada, Y., Ghafoori, P., Gumireddy, K., Li, Z., Loo, W. J., Lovegrove, F. & Lowe, J. & 13 others, Parish, L. C., Powley, W., Prasad, N., Da Rosa, J. C., Ruseva, M., Shokrian, N., Syed, F., Tang, C. H., Wong, G. K., Kelly, J. B., Wisniacki, N., Uings, I. & Guttman-Yassky, E., Feb 2026, In: Allergy: European Journal of Allergy and Clinical Immunology. 81, 2, p. 539-551 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Efficacy and safety of rocatinlimab for the treatment of moderate-to-severe atopic dermatitis in ROCKET-IGNITE and ROCKET-HORIZON: two global, double-blind, placebo-controlled, randomised phase 3 clinical trials
Guttman-Yassky, E., Kabashima, K., Worm, M., Luna, P. C., Hong, H. C. H., Chovatiya, R., Bernstein, J. A., Kern, J. S., Ehst, B. D., Magnolo, N., Herranz-Pinto, P., Stein Gold, L., Sofen, H., Pink, A. E., Esfandiari, E., Arai, T., Yang, Y., Shi, R., Barragan, C. & Kricorian, G. & 2 others, Schwartz-Sagi, L. & Bissonnette, R., 3 Jan 2026, In: The Lancet. 407, 10523, p. 53-66 14 p.
Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Efficacy and Safety of Tralokinumab Across Racial Subgroups in Adults with Moderate-to-Severe Atopic Dermatitis: Post Hoc Analysis of Phase III Trials
Mayo, T., Silverberg, J. I., Armstrong, A., Guttman-Yassky, E., Blauvelt, A., Esdaile, B., Kabashima, K., Gooderham, M., Kircik, L., Schneider, S., Bennike, N., von Eyben, R., Martel, B. C., Røpke, M. A., Katoh, N. & Alexis, A. F., Jan 2026, In: American Journal of Clinical Dermatology. 27, 1, p. 149-166 18 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Erratum: Correction: Dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers (The Journal of experimental medicine (2025) 222 11 PII: e2025049912162025c DOI: 10.1084/jem.20250499.)
Wouters, M., Ehlers, L., Van Eynde, W., Kars, M. E., Delafontaine, S., Kienapfel, V., Dzhus, M., Schrijvers, R., De Haes, P., Struyf, S., Bucciol, G., Itan, Y., Bolze, A., Voet, A., Hombrouck, A., Moens, L., Ogunjimi, B. & Meyts, I., 2 Feb 2026, In: Journal of Experimental Medicine. 223, 2
Research output: Contribution to journal › Comment/debate

Open Access
Expert Recommendations for the Diagnosis and Management of Chronic Hand Eczema in the United States
Silverberg, J. I., Cohen, D., Guttman-Yassky, E., Eichenfield, L. F., Simpson, E. L., Armstrong, A., Yu, J. D., Stein-Gold, L., Ehst, B. D., Begolka, W. S., Bunick, C. G. & Chovatiya, R., 2026, (Accepted/In press) In: American Journal of Clinical Dermatology.
Research output: Contribution to journal › Article › peer-review

Open Access
Immunological knowledge
Gelineau, A., Brown, B. D., Hall, E. J., Wang, L. L., Germain, R. N. & Benoist, C., 2026, (Accepted/In press) In: Nature Immunology.
Research output: Contribution to journal › Comment/debate
Large-Scale Blood Proteomic Analysis Across Different Inflammatory Skin Conditions Reveals Extensive Immune Dysregulation With Distinct Biomarker Profiles
Glickman, J. W., David, E., Shokrian, N., Hawkins, K., Duca, E. D., Hu, B. D., Navrazhina, K., Carroll, B., Mishra, A., Estrada, Y. D., Singer, G., Krueger, J. G. & Guttman-Yassky, E., Feb 2026, In: Allergy: European Journal of Allergy and Clinical Immunology. 81, 2, p. 524-538 15 p.
Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Long-Term Real-World Evaluation of Abrocitinib in Moderate-to-Severe Atopic Dermatitis Across a Diverse Patient Population in a Multi-site Hospital System
Lau, M., Largen, J., Levine, J., Del Duca, E., Mo, L., Tan, K. J., Liu, D., Amangeldiyeva, A., da Rosa, J. C., Edemobi, P., Ungar, B. & Guttman-Yassky, E., 2026, (Accepted/In press) In: American Journal of Clinical Dermatology.
Research output: Contribution to journal › Article › peer-review
mRNA-based MRI contrast agent for precise diagnosis of glioma and pseudoprogression
Li, H., Wang, L., Zhong, Y., Guo, K., Xue, Y., Wang, C., Wang, S., Hou, X., Chen, D. S., Liu, Z., Cao, D., Tian, M., Kang, D. D., Mu, X., Deng, B., McComb, D. W., Taouli, B., Brown, B. D. & Dong, Y., 2026, (Accepted/In press) In: Cell Biomaterials. 100342.
Research output: Contribution to journal › Article › peer-review

Open Access
Multiparametric MRI for Predicting Renal Function Deterioration and Chronic Kidney Disease Development in Patients Undergoing Nephrectomy for Renal Masses: A Pilot Study
Liu, M. M., Bane, O., Mu, X., Al-Mubarak, H., Reddy, A. M., Bolger, I., Abboud, G., Kennedy, P., Robson, P., Meilika, K., Horowitz, A., Kuhn, B., Farouk, S., Badani, K., Taouli, B. & Lewis, S., 2026, (Accepted/In press) In: Journal of Magnetic Resonance Imaging.
Research output: Contribution to journal › Article › peer-review
1 Scopus citations

Study Links Depression to Atopic Dermatitis–Related Immune Signature
Rizk, M., Murrough, J., Guttman, E. & Charney, D.
13/02/26
1 item of Media coverage
Press/Media
Major Depressive Disorder Shares Immune Abnormalities and Potential Therapeutic Targets With Inflammatory Skin Diseases, According to New Study
Rizk, M., Murrough, J., Guttman, E. & Charney, D.
11/02/26 → 13/02/26
5 items of Media coverage
Press/Media
Findings from Joseph Largen and Co-Authors Broaden Understanding of Atopic Dermatitis (Long-Term Real-World Evaluation of Abrocitinib in Moderate-to-Severe Atopic Dermatitis Across a Diverse Patient Population in a Multi-site Hospital System)
Guttman, E. & Ungar, B.
11/02/26
1 item of Media coverage
Press/Media
Findings from Icahn School of Medicine at Mount Sinai Broaden Understanding of Bacterial Infections and Mycoses (IgA defects in CVID lead to bacterial translocation, increased serum g-interferon, and BAFF)
Ho, H.-E. & Cunningham-Rundles, C.
9/02/26
1 item of Media coverage
Press/Media
Researchers from Icahn School of Medicine at Mount Sinai Provide Details of New Studies and Findings in the Area of Asthma (Skin tape strips identify age-specific immune, metabolic, and barrier dysregulation signatures in children, adolescents, ...)
Guttman, E.
3/02/26
1 item of Media coverage
Press/Media
AMERICAN SKIN ASSOCIATION ANNOUNCES APPOINTMENT OF PATRICK M. BRUNNER, MD, MSC TO MEDICAL ADVISORY COMMITTEE
Guttman, E. & Brunner, P.
2/02/26 → 3/02/26
29 items of Media coverage
Press/Media
Upadacitinib Safe for Atopic Dermatitis up to 7 Years in Pooled Analysis Findings
Guttman, E.
2/02/26
2 items of Media coverage
Press/Media
New Leadership at American Skin Association Enhances Research Focus
Guttman, E. & Brunner, P.
2/02/26
1 item of Media coverage
Press/Media
Trojan Horse Therapy Fights Metastatic Cancer
Brown, B.
30/01/26
1 item of Media coverage
Press/Media
A Trojan horse cancer therapy shows stunning results
Lin, M., Mollaoglu, G., Pia, L., Merad, M., Sanchez, R., Brown, B., Lin, M., Brody, J. & Baccarini, A.
30/01/26
1 item of Media coverage
Press/Media
Innovative Immunotherapy Targets Tumor Macrophages to Combat Metastatic Cancer
Brown, B.
30/01/26
1 item of Media coverage
Press/Media
Turning tumor macrophages from foes into allies
Brown, B.
29/01/26
1 item of Media coverage
Press/Media

Center for Inborn Errors of Immunity

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

Brian Brown

Minji Byun

Charlotte Cunningham-Rundles

Emma Guttman

Amir Horowitz

Yuval Itan

Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure

Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth

Clinical and Molecular Effect of the Anti–IL-18 Antibody Aletekitug in Adults With Atopic Dermatitis

Efficacy and safety of rocatinlimab for the treatment of moderate-to-severe atopic dermatitis in ROCKET-IGNITE and ROCKET-HORIZON: two global, double-blind, placebo-controlled, randomised phase 3 clinical trials

Efficacy and Safety of Tralokinumab Across Racial Subgroups in Adults with Moderate-to-Severe Atopic Dermatitis: Post Hoc Analysis of Phase III Trials

Erratum: Correction: Dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers (The Journal of experimental medicine (2025) 222 11 PII: e2025049912162025c DOI: 10.1084/jem.20250499.)

Expert Recommendations for the Diagnosis and Management of Chronic Hand Eczema in the United States

Immunological knowledge

Large-Scale Blood Proteomic Analysis Across Different Inflammatory Skin Conditions Reveals Extensive Immune Dysregulation With Distinct Biomarker Profiles

Long-Term Real-World Evaluation of Abrocitinib in Moderate-to-Severe Atopic Dermatitis Across a Diverse Patient Population in a Multi-site Hospital System

mRNA-based MRI contrast agent for precise diagnosis of glioma and pseudoprogression

Multiparametric MRI for Predicting Renal Function Deterioration and Chronic Kidney Disease Development in Patients Undergoing Nephrectomy for Renal Masses: A Pilot Study

Study Links Depression to Atopic Dermatitis–Related Immune Signature

Major Depressive Disorder Shares Immune Abnormalities and Potential Therapeutic Targets With Inflammatory Skin Diseases, According to New Study

Findings from Joseph Largen and Co-Authors Broaden Understanding of Atopic Dermatitis (Long-Term Real-World Evaluation of Abrocitinib in Moderate-to-Severe Atopic Dermatitis Across a Diverse Patient Population in a Multi-site Hospital System)

Findings from Icahn School of Medicine at Mount Sinai Broaden Understanding of Bacterial Infections and Mycoses (IgA defects in CVID lead to bacterial translocation, increased serum g-interferon, and BAFF)

Researchers from Icahn School of Medicine at Mount Sinai Provide Details of New Studies and Findings in the Area of Asthma (Skin tape strips identify age-specific immune, metabolic, and barrier dysregulation signatures in children, adolescents, ...)

AMERICAN SKIN ASSOCIATION ANNOUNCES APPOINTMENT OF PATRICK M. BRUNNER, MD, MSC TO MEDICAL ADVISORY COMMITTEE

Upadacitinib Safe for Atopic Dermatitis up to 7 Years in Pooled Analysis Findings

New Leadership at American Skin Association Enhances Research Focus

Trojan Horse Therapy Fights Metastatic Cancer

A Trojan horse cancer therapy shows stunning results

Innovative Immunotherapy Targets Tumor Macrophages to Combat Metastatic Cancer

Turning tumor macrophages from foes into allies

Center for Inborn Errors of Immunity

Fingerprint

Collaborations and top research areas from the last five years

Profiles

Research output

Press/Media