Center for Inborn Errors of Immunity

Icahn School of Medicine at Mount Sinai

87468 Citations
150 h-index
783 Article
131 Review article
56 Letter
51 Comment/debate
More

A phase 2a trial of brepocitinib for cicatricial alopecia
David, E., Shokrian, N., Del Duca, E., Meariman, M., Dubin, C., Hawkins, K., Andrews, E., Sikand, S., Singer, G., Oemar, B., Estrada, Y., Bose, S., Pulsinelli, J., Mahling, P., Da Rosa, J. C., Ungar, B., Peeva, E. & Guttman-Yassky, E., Mar 2025, In: Journal of the American Academy of Dermatology. 92, 3, p. 427-434 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
3 Scopus citations
Atopic dermatitis
Guttman-Yassky, E., Renert-Yuval, Y. & Brunner, P. M., 15 Feb 2025, In: The Lancet. 405, 10478, p. 583-596 14 p.
Research output: Contribution to journal › Review article › peer-review
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Belabed, M., Park, M. D., Blouin, C. M., Balan, S., Moon, C. Y., Freed, G., Quijada-Álamo, M., Peros, A., Mattiuz, R., Reid, A. M., Yatim, N., Boumelha, J., Azimi, C. S., LaMarche, N. M., Troncoso, L., Amabile, A., Le Berichel, J., Chen, S. T., Wilk, C. M. & Brown, B. D. & 10 others, Radford, K. J., Ghosh, S., Rothlin, C. V., Yvan-Charvet, L., Marron, T. U., Puleston, D. J., Wagenblast, E., Bhardwaj, N., Lamaze, C. & Merad, M., Feb 2025, In: Nature Immunology. 26, 2, p. 188-199 12 p., 94.
Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Clinical characterization of NOD2 variants in patients with common variable immunodeficiency
Lee, A. S. E., Feng, J., Kazancioglu, A. & Cunningham-Rundles, C., Jan 2025, In: Clinical Immunology. 270, 110401.
Research output: Contribution to journal › Letter › peer-review
Common Variable Immunodeficiency Clinical Manifestations Are Shaped by Presence and Type of Heterozygous NFKB1 Variants
Yin, J., Hayes, K. M., Ong, M. S., Mizgerd, J. P., Cunningham-Rundles, C., Dominguez, I., Barmettler, S., Farmer, J. R. & Maglione, P. J., Mar 2025, In: Journal of Allergy and Clinical Immunology: In Practice. 13, 3, p. 639-646 8 p.
Research output: Contribution to journal › Article › peer-review
Content evaluation of pruritus, skin pain and sleep disturbance patient-reported outcome measures for adolescents and adults with moderate-to-severe atopic dermatitis: qualitative interviews
Blauvelt, A., Reckleff, J., Zhao, Y., Clark, M., Kosa, K., Harris, N., Esfandiari, E., Martin, S., Whalley, D. & Guttman-Yassky, E., 1 Feb 2025, In: British Journal of Dermatology. 192, 2, p. 247-260 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
Deciphering the digenic architecture of congenital heart disease using trio exome sequencing data
Kars, M. E., Stein, D., Stenson, P. D., Cooper, D. N., Chung, W. K., Gruber, P. J., Seidman, C. E., Shen, Y., Tristani-Firouzi, M., Gelb, B. D. & Itan, Y., 6 Mar 2025, In: American Journal of Human Genetics. 112, 3, p. 583-598 16 p.
Research output: Contribution to journal › Article › peer-review
Disease diagnostics using machine learning of B cell and T cell receptor sequences
Zaslavsky, M. E., Craig, E., Michuda, J. K., Sehgal, N., Ram-Mohan, N., Lee, J. Y., Nguyen, K. D., Hoh, R. A., Pham, T. D., Röltgen, K., Lam, B., Parsons, E. S., Macwana, S. R., DeJager, W., Drapeau, E. M., Roskin, K. M., Cunningham-Rundles, C., Moody, M. A., Haynes, B. F. & Goldman, J. D. & 17 others, Heath, J. R., Chinthrajah, R. S., Nadeau, K. C., Pinsky, B. A., Blish, C. A., Hensley, S. E., Jensen, K., Meyer, E., Balboni, I., Utz, P. J., Merrill, J. T., Guthridge, J. M., James, J. A., Yang, S., Tibshirani, R., Kundaje, A. & Boyd, S. D., 21 Feb 2025, In: Science. 387, 6736, p. eadp2407
Research output: Contribution to journal › Article › peer-review
Drug survival of alitretinoin treatment for chronic hand eczema: A Danish nationwide cohort study
Rønnstad, A. T. M., Nielsen, M. L., Schlapbach, C., Guttman-Yassky, E., Silverberg, J. I., Thomsen, S. F., Thyssen, J. P. & Egeberg, A., Feb 2025, In: Journal of the European Academy of Dermatology and Venereology. 39, 2, p. e118-e121
Research output: Contribution to journal › Letter › peer-review

1 Scopus citations
Dupilumab Treatment Improves Lichenification in Atopic Dermatitis in Different Age and Racial Groups
Guttman-Yassky, E., Katoh, N., J Cork, M., Jagdeo, J., F Alexis, A., Chen, Z., A Levit, N. & B Rossi, A., 1 Feb 2025, In: Journal of Drugs in Dermatology. 24, 2, p. 167-173 7 p.
Research output: Contribution to journal › Article › peer-review
Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses
Gutzeit, C., Grasset, E. K., Matthews, D. B., Maglione, P. J., Britton, G. J., Miller, H., Magri, G., Tomalin, L., Stapylton, M., Canales-Herrerias, P., Sominskaia, M., Guzman, M., Pybus, M., Vaquero, S. T., Radigan, L., Tachó-Piñot, R., Nalda, A. M., Prat, M. G., Gallo, M. M. & Dieli-Crimi, R. & 6 others, Clemente, J. C., Mehandru, S., Suarez-Farinas, M., Faith, J. J., Cunningham-Rundles, C. & Cerutti, A., 14 Feb 2025, In: Science advances. 11, 7, eado9455.
Research output: Contribution to journal › Article › peer-review
Long-Term Safety and Efficacy with Roflumilast Cream 0.15% in Patients Aged ≥6 Years with Atopic Dermatitis: A Phase 3 Open-Label Extension Trial
Simpson, E. L., Eichenfield, L. F., Papp, K. A., Forman, S. B., Hebert, A. A., Gonzalez, M. E., Gooderham, M. J., Hong, H. C. H., Prajapati, V. H., Guttman-Yassky, E., Silverberg, J. I., Seal, M. S., Krupa, D., Almaraz, E., Hanna, D., Burnett, P., Snyder, S., Chu, D. H., Higham, R. C. & Berk, D. R., 2025, (Accepted/In press) In: Dermatitis.
Research output: Contribution to journal › Article › peer-review

Weekly: Apogee Therapeutics (APGE: $39.84) decreases on firm volume, Cash Runway of 7 months; -10c [0.3%]
Guttman, E.
22/03/25
1 item of Media coverage
Press/Media
‘Giants’ to tackle primary immunodeficiencies for practicing physicians during conference
Cunningham-Rundles, C.
19/03/25
1 item of Media coverage
Press/Media
Weekly: Apogee Therapeutics (APGE: $39.94) surges 10.5%, 2 weeks' volume in a week; +$3.80 [10.5%] Vol Index 1.6 [1 is avg]
Guttman, E.
15/03/25
1 item of Media coverage
Press/Media
Patients with unresponsive atopic dermatitis saw improvement with rocatinlimab
Guttman, E.
14/03/25
1 item of Media coverage
Press/Media
Apogee Therapeutics sinks 15% in 2025, underperforming 83% of its global peers
Guttman, E.
14/03/25
1 item of Media coverage
Press/Media
Purple Biotech Reports Fourth Quarter and Full-Year 2024 Financial Results
Horowitz, A.
10/03/25
13 items of Media coverage
Press/Media
Purple Biotech Reports Fourth Quarter and Full-Year 2024 Financial Results
Horowitz, A.
10/03/25
1 item of Media coverage
Press/Media
T-Cell Rebalancing Therapy Active in Previously Treated Atopic Dermatitis
Guttman, E.
10/03/25
1 item of Media coverage
Press/Media
Scientists find hidden genetic cause of congenital heart disease
Itan, Y.
9/03/25
1 item of Media coverage
Press/Media
Weekly: Apogee Therapeutics (APGE: $36.14) shares post best week in thirty-four weeks; +$4.70 [14.9%] Vol Index 1.7 [1 is avg]
Guttman, E.
8/03/25
1 item of Media coverage
Press/Media
Apogee Therapeutics decreases 12% in past year
Guttman, E.
4/03/25
1 item of Media coverage
Press/Media
Monthly: Apogee Therapeutics (APGE: $31.44) drops 24% on high volatility in February 2025
Guttman, E.
3/03/25
1 item of Media coverage
Press/Media

Center for Inborn Errors of Immunity

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

Brian Brown

Minji Byun

Charlotte Cunningham-Rundles

Emma Guttman

Amir Horowitz

Yuval Itan

A phase 2a trial of brepocitinib for cicatricial alopecia

Atopic dermatitis

Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer

Clinical characterization of NOD2 variants in patients with common variable immunodeficiency

Common Variable Immunodeficiency Clinical Manifestations Are Shaped by Presence and Type of Heterozygous NFKB1 Variants

Content evaluation of pruritus, skin pain and sleep disturbance patient-reported outcome measures for adolescents and adults with moderate-to-severe atopic dermatitis: qualitative interviews

Deciphering the digenic architecture of congenital heart disease using trio exome sequencing data

Disease diagnostics using machine learning of B cell and T cell receptor sequences

Drug survival of alitretinoin treatment for chronic hand eczema: A Danish nationwide cohort study

Dupilumab Treatment Improves Lichenification in Atopic Dermatitis in Different Age and Racial Groups

Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses

Long-Term Safety and Efficacy with Roflumilast Cream 0.15% in Patients Aged ≥6 Years with Atopic Dermatitis: A Phase 3 Open-Label Extension Trial

Weekly: Apogee Therapeutics (APGE: $39.84) decreases on firm volume, Cash Runway of 7 months; -10c [0.3%]

‘Giants’ to tackle primary immunodeficiencies for practicing physicians during conference

Weekly: Apogee Therapeutics (APGE: $39.94) surges 10.5%, 2 weeks' volume in a week; +$3.80 [10.5%] Vol Index 1.6 [1 is avg]

Patients with unresponsive atopic dermatitis saw improvement with rocatinlimab

Apogee Therapeutics sinks 15% in 2025, underperforming 83% of its global peers

Purple Biotech Reports Fourth Quarter and Full-Year 2024 Financial Results

Purple Biotech Reports Fourth Quarter and Full-Year 2024 Financial Results

T-Cell Rebalancing Therapy Active in Previously Treated Atopic Dermatitis

Scientists find hidden genetic cause of congenital heart disease

Weekly: Apogee Therapeutics (APGE: $36.14) shares post best week in thirty-four weeks; +$4.70 [14.9%] Vol Index 1.7 [1 is avg]

Apogee Therapeutics decreases 12% in past year

Monthly: Apogee Therapeutics (APGE: $31.44) drops 24% on high volatility in February 2025

Center for Inborn Errors of Immunity

Fingerprint

Collaborations and top research areas from the last five years

Profiles

Research output

Press/Media