Cell, Developmental, and Regenerative Biology

Projects

Projects per year 1985 2001 2004 2009 2011 2012 2014 2015 2016 2018 2020 2021 2024

• 48 Active
• 131 Finished

Projects per year

Search results

• Finished

  Towards Understanding Molecular Mechanisms of Human Hematopoietic Stem Cells' Quiescence

  Ghaffari, S.

  National Heart, Lung, and Blood Institute

  15/02/22 → 31/01/23

  Project: Research

  • regulation 100%
  • communication 90%
  • lack 87%

• A Cytochrome P450 Therapeutic Space for Tauopathies

  Dar, A. & Cagan, R.

  National Institute on Aging

  30/09/21 → 31/08/22

  Project: Research

  • Anastrozole 100%
  • cytochrome P-450 92%
  • Tauopathies 80%
  • therapeutics 76%
  • neurodegenerative diseases 62%

• A Chemical Genetic Approach to Exploring Novel Therapeutic Space for Colorectal Cancer

  Dar, A., Cagan, R., Dar, A. & Cagan, R. R. L.

  National Cancer Institute

  1/03/21 → 28/02/23

  Project: Research

  • regorafenib 100%
  • Phosphotransferases 62%
  • Colorectal Neoplasms 60%
  • Polypharmacology 20%
  • Aurora Kinase A 17%

• Coordinate regulation of erythroid and macrophage lineages in development by EKLF/KLF1

  Bieker, J. & Bieker, J. J.

  National Institute of Diabetes and Digestive and Kidney Diseases

  15/04/20 → 31/01/23

  Project: Research

  • erythroid Kruppel-like factor 100%
  • Macrophages 37%
  • Islands 16%
  • Zinc Fingers 9%
  • Erythrocytes 9%

• Protection of early embryogenesis and pluripotent stem cells against genetic parasites through a primitive immune system

  Zwaka, T. & Zwaka, T. P.

  National Institute of Child Health and Human Development

  23/03/20 → 28/02/23

  Project: Research

  • Pluripotent Stem Cells 100%
  • Embryonic Development 75%
  • Parasites 67%
  • Immune System 67%
  • Retroelements 42%

• Role of ontogeny and niche on human macrophage development

  Lavine, K. J. & Sturgeon, C.

  National Institute of Allergy and Infectious Diseases

  7/02/20 → 31/01/22

  Project: Research

  • Human Development 100%
  • Macrophages 90%
  • Pluripotent Stem Cells 36%
  • Chromatin 18%
  • Essential Genes 11%

• Nuclear import of beta-Catenin in Wnt-signaling

  Mlodzik, M.

  National Institute of Child Health and Human Development

  3/02/20 → 31/01/22

  Project: Research

  • Catenins 100%
  • Kinesin 92%
  • Cell Nucleus Active Transport 65%
  • beta Catenin 55%
  • Drosophila 20%

• KLF-mediated coordination of signaling and epigenetic mechanisms in the skin

  Millar, S. S. E. & Millar, S.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  1/02/20 → 31/01/23

  Project: Research

  • hair follicles 100%
  • Hair Follicle 90%
  • epigenetics 76%
  • stem cells 66%
  • skin (animal) 59%

• Transcriptional regulators of iris muscle cell development

  Blenkinsop, T.

  NATIONAL EYE INSTITUTE

  1/01/20 → 31/12/21

  Project: Research

  • Iris 100%
  • Muscle Development 81%
  • Muscle Cells 64%
  • Muscles 54%
  • Neural Tube 34%

• TET2-mediated transcriptional and epigenetic control of normal and malignant hematopoiesis

  Wang, J., Xu, M. & Xu, M.

  National Heart, Lung, and Blood Institute

  1/05/19 → 31/03/21

  Project: Research

  • Hematopoietic Stem Cells 100%
  • Hematopoiesis 81%
  • Epigenomics 61%
  • RNA 22%
  • DNA Demethylation 13%

• Dermal Papilla Regulation and Function for Stem Cell Activation in the Hair Cycle

  Rendl, M.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  1/04/19 → 31/03/20

  Project: Research

  • Stem Cells 100%
  • Skin 94%
  • Stem Cell Niche 33%
  • Hair 32%
  • Hair Follicle 30%

• Generation of cultured RBCs with rare phenotypes for transfusion from sources usually discarded during regular blood donations

  Bieker, J. & Migliaccio, A. R. F.

  National Heart, Lung, and Blood Institute

  20/09/18 → 31/05/19

  Project: Research

  • Blood Donors 100%
  • Phenotype 67%
  • Costs and Cost Analysis 50%
  • Transfusion Medicine 37%
  • Gene Editing 32%

• Transcriptional and Epigenetic Control of Pluripotency and Development by Zfp281

  Wang, J. & Wang, J.

  National Institute of General Medical Sciences

  6/08/18 → 30/04/19

  Project: Research

  • Germ Layers 100%
  • Epigenomics 79%
  • Human Embryonic Stem Cells 56%
  • Stem Cells 23%
  • Genetic Epigenesis 22%

• A Transgenic System for Targeted Ablation of Reproductive and Maternal-Effectgenes

  Marlow, F.

  National Institute of Child Health and Human Development

  6/08/18 → 31/07/20

  Project: Research

  • germ cells 100%
  • maternal effect 95%
  • genetically modified organisms 82%
  • Danio rerio 60%
  • genes 50%

• Intrinsic and extrinsic control of erythropoietic maturation

  Bieker, J.

  National Institute of Diabetes and Digestive and Kidney Diseases

  15/07/18 → 30/06/19

  Project: Research

  • erythroid Kruppel-like factor 100%
  • Macrophages 23%
  • Islands 11%
  • Congenital Dyserythropoietic Anemia 9%
  • Cell Cycle 8%

• An inquiry into the function of Ronin in embryogenesis and pluripotent stem cells

  Zwaka, T.

  National Institute of General Medical Sciences

  11/07/18 → 31/03/19

  Project: Research

  • Pluripotent Stem Cells 100%
  • Embryonic Development 83%
  • Stem Cells 74%
  • Protein Multimerization 38%
  • Genetic Enhancer Elements 32%

• Cell motility regulation by PCP signaling

  Mlodzik, M.

  National Institute of Child Health and Human Development

  8/06/18 → 31/05/20

  Project: Research

  • Cell Polarity 100%
  • Cell Movement 57%
  • Signal Transduction 50%
  • Drosophila 24%
  • Eye 12%

• Role of THC as an inhibitor of Shh-dependent midlineand neuronal patterning

  Krauss, R.

  National Institute on Drug Abuse

  1/06/18 → 31/05/21

  Project: Research

  • Holoprosencephaly 100%
  • Dronabinol 78%
  • Hedgehogs 30%
  • Mutation 16%
  • Neural Tube 14%

• FASEB SRC on Skeletal Muscle Satellite Cells and Regeneration

  Krauss, R.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  1/06/18 → 31/05/19

  Project: Research

  • skeletal muscle 100%
  • Biological Sciences 79%
  • career development 54%
  • cells 50%
  • myocytes 45%

• Delineating the functions of EKLF during mammalian terminal erythroid differentiation

  Gnanapragasam, M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/03/18 → 31/01/23

  Project: Research

  • erythroid Kruppel-like factor 100%
  • Congenital Dyserythropoietic Anemia 52%
  • Cytokinesis 45%
  • Erythroblasts 41%
  • DNA Replication 38%

• Defining the spatio-temporal mechanisms of ventricular cell specification and differentiation

  DuBois, N.

  National Heart, Lung, and Blood Institute

  15/02/18 → 31/01/22

  Project: Research

  • Pluripotent Stem Cells 100%
  • Cell Differentiation 97%
  • Cardiac Myocytes 47%
  • Heart Diseases 27%
  • Heart 22%

• Mechanisms of neural tube closure

  Sokol, S. & Sokol, S.

  National Institute of Neurological Disorders and Stroke

  15/12/17 → 30/11/22

  Project: Research

  • Neural Tube 100%
  • Neural Plate 55%
  • Cell Polarity 49%
  • Nervous System Diseases 31%
  • Vertebrates 30%

• Proximity- and complementation-based analysis of signaling complexes

  Sokol, S.

  NIH Office of the Director

  5/09/17 → 30/06/19

  Project: Research

  • Cell Polarity 100%
  • Proteins 39%
  • Protein Interaction Maps 33%
  • Biotin 29%
  • Ligases 29%

• Administrative Core

  Millar, S. & Cotsarelis, G.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  1/09/17 → 31/07/21

  Project: Research

  • mentoring 100%
  • financial management 46%
  • trainee 34%
  • grant 30%
  • website 29%

• SRF Modularity During Craniofacial Development

  Dinsmore, C.

  National Institute of Dental and Craniofacial Research

  1/12/16 → 30/11/19

  Project: Research

  • Serum Response Factor 100%
  • Ternary Complex Factors 35%
  • myocardin 32%
  • Transcription Factors 23%
  • Cleft Lip 17%

• Molecular Profiling of Schizophrenia

  Chess, A., Roussos, P. & Sklar, P.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  1/09/16 → 31/12/20

  Project: Research

  • Schizophrenia 100%
  • Proteomics 35%
  • Epigenomics 33%
  • Organized Financing 20%
  • Autopsy 18%

• Atrial-ventricular specification during mammalian heart development

  DuBois, N.

  National Heart, Lung, and Blood Institute

  1/09/16 → 28/02/18

  Project: Research

  • Heart 100%
  • Pluripotent Stem Cells 77%
  • Heart Diseases 71%
  • Population 51%
  • Pericardium 49%

• Catalytic Activity Independent Functions of TET Proteins in Pluripotency

  Wang, J.

  National Institute of Child Health and Human Development

  1/07/16 → 30/06/18

  Project: Research

  • Retroelements 100%
  • Stem Cells 55%
  • Proteins 37%
  • Histones 35%
  • Epigenetic Repression 31%

• Somatic Mosaicism in Schizophrenia and Control Brains

  Chess, A., Akbarian, S. & Walsh, C. A.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  23/09/15 → 30/06/21

  Project: Research

  • Mosaicism 100%
  • Schizophrenia 70%
  • Brain 40%
  • Epigenome 13%
  • Twins 11%

• Nanobodies as markers and tools for studies of Xenopus embryonic development

  Sokol, S.

  National Institute of General Medical Sciences

  15/09/15 → 31/05/20

  Project: Research

  • Single-Domain Antibodies 100%
  • Xenopus 67%
  • Embryonic Development 52%
  • New World Camelids 21%
  • Proteome 15%

• Drosophila as a Screening Platform for Novel Lung Cancer Therapeutics

  Cagan, R.

  U.S. Army

  1/09/15 → 1/09/15

  Project: Research

  • Lung Neoplasms 100%
  • Drosophila 71%
  • Neoplasms 38%
  • Diptera 32%
  • Pharmaceutical Preparations 24%

• DROSOPHILA AS A SCREENING PLATFORM FOR NOVEL LUNG CANCER THERAPEUTICS

  Cagan, R.

  Congressionally Directed Medical Research Programs

  1/09/15 → 31/08/17

  Project: Research

  • Drosophila 100%
  • Lung Neoplasms 99%
  • Neoplasms 50%
  • Mutation 33%
  • Diptera 25%

• Mouse Genetics

  Kelley, K.

  National Cancer Institute

  1/08/15 → 31/07/20

  Project: Research

  • mice 100%
  • neoplasms 76%
  • genetic resources 71%
  • embryo (animal) 30%
  • animal models 24%

• A New Disease Platform Leveraging Complex Drosophila and Mammalian Models

  Cagan, R.

  NIH Office of the Director

  1/08/15 → 30/06/20

  Project: Research

  • Stem cells 100%
  • Genetics 95%
  • Fruits 81%
  • Cells 68%
  • Lead 65%

• Camelid antibodies as sensitive proteomics tools for developmental studies

  Sokol, S.

  National Institute of Child Health and Human Development

  8/09/14 → 31/08/16

  Project: Research

  • Single-Domain Antibodies 100%
  • Xenopus 55%
  • Proteomics 43%
  • Proteome 31%
  • Antibodies 26%

• Novel regulators of apical constriction

  Sokol, S.

  National Institute of Child Health and Human Development

  1/09/14 → 31/08/16

  Project: Research

  • Constriction 100%
  • Gastrula 39%
  • Gastrulation 36%
  • Xenopus 30%
  • Vertebrates 25%

• Regulation of Wnt signaling in tooth development and regeneration

  Millar, S.

  National Institute of Dental and Craniofacial Research

  1/08/14 → 31/07/16

  Project: Research

  • Tooth 100%
  • Regeneration 66%
  • beta Catenin 57%
  • Bioengineering 27%
  • Wnt Receptors 21%

• Regulation of Embryonic Patterning and Adult Stem Cells of Oral Appendages

  Millar, S. & Millar, S. E.

  National Institute of Dental and Craniofacial Research

  1/08/14 → 31/07/20

  Project: Research

  • Adult Stem Cells 100%
  • Embryonic Stem Cells 86%
  • Catenins 68%
  • Tooth 61%
  • Tongue 45%

• Ubiquitin-like protein modifications in planar cell polarity

  Mlodzik, M.

  National Institute of General Medical Sciences

  1/05/14 → 31/03/18

  Project: Research

  • Ubiquitins 100%
  • Cell Polarity 87%
  • Drosophila 73%
  • Ubiquitin 39%
  • Mammals 34%

• Intrinsic and extrinsic control of erythropoietic maturation

  Bieker, J.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/14 → 30/06/18

  Project: Research

  • erythroid Kruppel-like factor 100%
  • Erythroid Cells 21%
  • Macrophages 16%
  • Erythropoiesis 13%
  • Islands 12%

• Programming Hematopoiesis

  Moore, K. & Lemischka, I.

  National Heart, Lung, and Blood Institute

  1/04/14 → 31/03/19

  Project: Research

  • Transcription Factor 4 100%
  • Hematopoiesis 76%
  • Hematopoietic Stem Cells 65%
  • Transcription Factors 62%
  • Fibroblasts 37%

• SELECTIVE ADDRESSED THERAPY OF PROSTATE CANCER TARGETED TO THE VASCULAR FOLLICLE-STIMULATING HORMONE RECEPTOR

  Radu, A. N.

  Congressionally Directed Medical Research Programs

  1/02/14 → 31/01/15

  Project: Research

  • Tumors 100%
  • Hormones 78%
  • Blood vessels 50%
  • Proteins 29%
  • Tissue 18%

• Exploring How Dermal Papilla Precursors Regulate Hair Follicle Formation

  Rendl, M.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  1/08/13 → 31/07/19

  Project: Research

  • Hair Follicle 100%
  • Skin 51%
  • Stem Cells 33%
  • Stem Cell Niche 25%
  • Hair 13%

• HDAC functions in skin development, renewal and disease

  Millar, S.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  1/04/13 → 31/03/19

  Project: Research

  • Histone Deacetylases 100%
  • Skin 41%
  • Epidermis 20%
  • Mi-2 Nucleosome Remodeling and Deacetylase Complex 17%
  • Pemetrexed 13%

• 2013 Epithelial Differentiation and Keratinization GRC/GRS

  Millar, S.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  1/04/13 → 31/03/14

  Project: Research

  • Skin 100%
  • Stem Cells 80%
  • Research Personnel 76%
  • Genomics 73%
  • Microbiota 72%

• Novel Determinants of Terminal Erythroid Maturation

  Bresnick, E. H. & Ghaffari, S.

  National Heart, Lung, and Blood Institute

  26/09/12 → 31/12/16

  Project: Research

  • Autophagy 100%
  • Thalassemia 34%
  • Erythroid Cells 23%
  • Erythropoiesis 22%
  • Oxidative Stress 20%

• Toward understanding the molecular mechanisms of Merkel cell fate determination

  Ezhkova, E.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  10/09/12 → 31/07/15

  Project: Research

  • Merkel Cells 100%
  • Hair Follicle 28%
  • Chromatin 23%
  • Skin 17%
  • Cell Lineage 9%

• Planar Cell Polarity regulation by transmembrane proteins

  Mlodzik, M.

  National Institute of General Medical Sciences

  1/09/12 → 31/08/18

  Project: Research

  • Cell Polarity 100%
  • Drosophila 45%
  • Cell Movement 37%
  • Neural Tube Defects 20%
  • Frizzled Receptors 18%

• A Drosophila Model Linking Diet-induced Obesity and Cancer (PQ 1)

  Cagan, R.

  National Cancer Institute

  20/08/12 → 31/05/17

  Project: Research

  • Drosophila 100%
  • Obesity 71%
  • Diet 70%
  • Dietary Sucrose 42%
  • Neoplasms 34%

• A Novel Signaling Pathway in Planar Cell Polarity Establishment

  Mlodzik, M.

  National Institute of Child Health and Human Development

  1/08/12 → 31/07/13

  Project: Research

  • Cell Polarity 100%
  • Drosophila 38%
  • Ciliopathies 20%
  • Mammals 18%
  • Frizzled Receptors 15%