Cardiovascular Research Institute

Projects

Projects per year 1986 2017 2018 2019 2024

• 27 Active
• 89 Finished

Projects per year

Search results

• Active

  Comprehensive genomic and inflammatory profiling of vaccine-associated myocarditis

  Kontorovich, A.

  National Institute of Allergy and Infectious Diseases

  3/11/22 → 31/10/23

  Project: Research

  • Myocarditis 100%
  • Human Genetics 81%
  • Vaccines 66%
  • Genetic Variation 64%
  • Cardiac Myocytes 62%

• Congenital Heart Disease Expert Curation Panel

  Roberts, A. A. E. & Gelb, B.

  National Institute of Child Health and Human Development

  1/08/22 → 30/06/23

  Project: Research

  • Congenital Heart Defects 100%
  • Heart Diseases 37%
  • Genes 22%
  • Genetic Testing 18%
  • Bicuspid Aortic Valve 8%

• Role of Epac1 in the Pathogenesis of Pulmonary Fibrosis

  Hadri, L.

  National Heart, Lung, and Blood Institute

  1/04/22 → 31/03/23

  Project: Research

  • Idiopathic Pulmonary Fibrosis 100%
  • Pulmonary Fibrosis 90%
  • Fibroblasts 34%
  • Lung Diseases 32%
  • Fibrosis 31%

• Identification of CaMKII as a novel substrate of dopaminylation following heroin self administration

  Stewart, A.

  National Institute on Drug Abuse

  19/01/22 → 18/01/24

  Project: Research

  • Substance-Related Disorders 100%
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2 96%
  • Self Administration 90%
  • Heroin 86%
  • Dopamine 63%

• Circulating Extracellular Vesicles in the Pathogenesis of Type 1 Diabetes

  Vasavada, R. R. C., Sahoo, S., Sahoo, S. S. & Vasavada, R.

  National Institute of Diabetes and Digestive and Kidney Diseases

  24/08/21 → 31/05/23

  Project: Research

  • Extracellular Vesicles 100%
  • Type 1 Diabetes Mellitus 71%
  • Early Diagnosis 22%
  • Research Subjects 17%
  • Preliminary Data 15%

• Influence of sleep on the hematopoietic niche and atherosclerosis during aging

  McAlpine, C. & Mcalpine, C. S.

  National Heart, Lung, and Blood Institute

  1/07/21 → 31/05/23

  Project: Research

  • Sleep 100%
  • Atherosclerosis 63%
  • Orexins 40%
  • Sleep Deprivation 36%
  • Cardiovascular Diseases 29%

• DREAM Complex Maintenance of Human Beta Cell Quiescence

  Stewart, A. A. F., Wang, P. P., Stewart, A. & Wang, P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/07/21 → 31/05/23

  Project: Research

  • Cell Proliferation 100%
  • Psychological Inhibition 82%
  • Insulinoma 63%
  • Transforming Growth Factor beta 46%
  • Chromatin 44%

• Influence of sleep on hematopoietic stem cell diversity and clonality in cardiovascular disease

  McAlpine, C. & Mcalpine, C. S.

  National Heart, Lung, and Blood Institute

  1/06/21 → 31/05/23

  Project: Research

  • Hematopoietic Stem Cells 100%
  • Sleep 71%
  • Cardiovascular Diseases 43%
  • Hematopoiesis 35%
  • Sleep Deprivation 30%

• Uncovering early signals of hereditary TTR amyloidosis in minority populations at high genetic risk

  Abul-Husn, N., Abul-husn, N. S., Kontorovich, A. A. R. & Kontorovich, A.

  National Heart, Lung, and Blood Institute

  1/04/21 → 31/03/23

  Project: Research

  • Familial Amyloidosis 100%
  • Hispanic Americans 21%
  • Amyloidosis 18%
  • Population 17%
  • TimeLine 16%

• Immune mechanisms of influenza A virus-induced susceptibility to myocardial infarction

  Downey, J. J. & Swirski, F.

  Institute of Infection and Immunity

  1/03/21 → 29/02/24

  Project: Research

  • Human Influenza 100%
  • Influenza A virus 86%
  • Myocardial Infarction 86%
  • Cardiovascular Diseases 47%
  • Monocytes 36%

• MerTK in NASH-related liver fibrosis

  Cai, B. & Cai, B.

  National Institute of Diabetes and Digestive and Kidney Diseases

  16/07/20 → 30/04/23

  Project: Research

  • Non-alcoholic Fatty Liver Disease 100%
  • Liver Cirrhosis 90%
  • Fibrosis 68%
  • Hepatic Stellate Cells 43%
  • Palmitic Acid 25%

• Understanding the Molecular Mechanisms of Fibromuscular Dysplasia

  Kadian-Dodov, D. L., Kovacic, J. J. C. & Kovacic, J.

  National Heart, Lung, and Blood Institute

  15/05/20 → 30/04/23

  Project: Research

  • Fibromuscular Dysplasia 100%
  • Gene Regulatory Networks 69%
  • Blood Vessels 14%
  • Phenotype 11%
  • Fibroblasts 9%

• ISS: Microphysiologic Model of Human Cardiovascular Stiffness-Related Diseases in Microgravity

  Costa, K. & Sachs, D.

  National Science Foundation

  1/09/19 → 31/08/23

  Project: Research

  • Weightlessness 100%
  • Cardiovascular Models 77%
  • Organoids 47%
  • Cardiovascular System 47%
  • Astronauts 33%

• Hematopoiesis in cardiovascular disease

  Nahrendorf, M. M., Lin, C. C. P., Scadden, D. D. T., Swirski, F. F. K., Joung, J. J. K., Joung, K. J., Naxerova, K. K., Lin, C. P., Nahrendorf, M., Scadden, D. T. & Swirski, F.

  1/08/19 → 31/07/23

  Project: Research

  • Hematopoiesis 100%
  • Leukocytosis 25%
  • Myocardial Infarction 25%
  • Hematopoietic Stem Cells 22%
  • Inflammation 20%

• Deciphering the Neonatal Cardiac Regenerative Potential and Regulators in Large Animals

  Zhang, J. J., Sadek, H. H., Zangi, L., Sadek, H. & Zhang, J.

  National Heart, Lung, and Blood Institute

  15/07/19 → 30/06/23

  Project: Research

  • Cell Cycle Checkpoints 100%
  • Muscle Cells 94%
  • Mammals 90%
  • Heart 83%
  • Heart Diseases 83%

• AAV-Exosomes: Escaping Neutralizing Antibody and Enhancing Delivery

  Sahoo, S. & Sahoo, S.

  National Heart, Lung, and Blood Institute

  1/07/19 → 30/06/23

  Project: Research

  • Exosomes 100%
  • Neutralizing Antibodies 69%
  • Genes 20%
  • Heart Failure 14%
  • Genetic Therapy 13%

• Project 3: Remote control of hematopoiesis in cardiovascular disease

  Swirski, F. F. K. & Swirski, F.

  National Heart, Lung, and Blood Institute

  1/07/19 → 31/07/23

  Project: Research

  • remote control 100%
  • hematopoiesis 87%
  • cardiovascular diseases 75%
  • bone marrow 73%
  • Hematopoiesis 37%

• SPACE RELEVANT RADIATION-INDUCED CARDIOVASCULAR DISEASE RISK THRESHOLDS: EFFECT OF GENDER ON THE OUTCOME

  Goukassian, D.

  Johnson Space Center

  10/04/19 → …

  Project: Research

  • Radiation 100%
  • Cardiovascular Diseases 80%
  • United States National Aeronautics and Space Administration 34%
  • Radiation Exposure 25%
  • Theoretical Models 19%

• Elucidation of the role of human genetic factors underlying viral myocarditis susceptibility

  Kontorovich, A. A. R. & Kontorovich, A.

  National Heart, Lung, and Blood Institute

  6/07/18 → 30/06/23

  Project: Research

  • Myocarditis 100%
  • Human Genetics 92%
  • Mentors 33%
  • Virology 23%
  • RNA Viruses 20%

• PET nanoreporter image-guided breast cancer therapy

  Fayad, Z., Pérez-medina, C. C., Fayad, Z. A., Grimm, J. J., Mulder, W., Perez-Medina, C. & Reiner, T.

  National Cancer Institute

  15/06/18 → 31/05/23

  Project: Research

  • Nanomedicine 100%
  • Positron-Emission Tomography 68%
  • Breast Neoplasms 46%
  • liposomal doxorubicin 39%
  • Technology 33%

• Cardiomyocyte-specific modified mRNA of Pkm2 for induction of cardiac regeneration in ischemic heart failure

  Zangi, L.

  National Heart, Lung, and Blood Institute

  1/06/18 → 31/05/23

  Project: Research

  • Regeneration 100%
  • Cardiac Myocytes 97%
  • Heart Failure 83%
  • Messenger RNA 68%
  • Genetic Therapy 55%

• Increasing Ischemic Myocardial Tissue Perfusion by Mechanical LV Support

  Ishikawa, K. K. & Ishikawa, K.

  National Heart, Lung, and Blood Institute

  15/12/17 → 30/11/23

  Project: Research

  • Cardiogenic Shock 100%
  • Hemodynamics 57%
  • Heart-Assist Devices 38%
  • Clinical Studies 30%
  • Equipment and Supplies 27%

• DYRK Inhibitors for Human Beta Cell Expansion

  Stewart, A., Garcia-ocana, A. A., Devita, R. J., García-Ocaña, A., DeVita, R. & Stewart, A. F.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/03/16 → 31/05/23

  Project: Research

  • Harmine 100%
  • National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) 60%
  • Libraries 41%
  • Cell Proliferation 33%
  • Small Molecule Libraries 32%

• SYSTEMIC INFLAMMATORY NETWORKS IN ALZHEIMER'S DISEASE

  Swirski, F. & Nahrendorf, M. M.

  Cure Alzheimer's Fund

  1/01/15 → …

  Project: Research

  • Alzheimer Disease 100%
  • Inflammation 58%
  • Dementia 33%
  • Organized Financing 23%
  • Symptom Flare Up 22%

• The Effect of Aging on DNA Repair and Mutation Rate: Modulation by DNA Oligonucleotide Therapy

  Goukassian, D.

  American Federation for Aging Research

  1/01/00 → …

  Project: Research

• Training Program in Molecular and Cellular Cardiology

  Gelb, B. B. D., Gelb, B., Hajjar, R., Kovacic, J. & Taubman, M. M. B.

  National Heart, Lung, and Blood Institute

  1/07/95 → 31/07/23

  Project: Research

  • Cardiology 100%
  • Education 63%
  • Translational Medical Research 35%
  • Research Personnel 29%
  • Physicians 22%

• T32 Research Training in Diabetes and Endocrinology

  O'doherty, R. R. M., Robinson, A. A. G., Stewart, A., Derubertis, F. F. R., Goodpaster, B. H., O'doherty, R. M. & Stewart, A. F.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/07/86 → 30/06/23

  Project: Research

  • endocrinology 100%
  • diabetes 82%
  • chronic illness 62%
  • mentoring 58%
  • trainee 33%
• Finished

  Biological and Medicinal Chemistry Approaches to Human Beta Cell Regeneration

  Stewart, A., DeVita, R. & García-Ocaña, A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/07/20 → 31/03/22

  Project: Research

  • Chemistry 100%
  • Molecule 85%
  • Agent Interacting With Transmitter, Hormone or Drug Receptor 63%
  • Exendin-4 34%
  • Harmine 30%

• Influence of sleep on hematopoietic stem cell diversity and clonality in cardiovascular disease

  McAlpine, C.

  National Heart, Lung, and Blood Institute

  1/05/20 → 30/04/21

  Project: Research

  • Hematopoietic Stem Cells 100%
  • Sleep 71%
  • Cardiovascular Diseases 43%
  • Hematopoiesis 35%
  • Sleep Deprivation 30%

• Cellular and molecular mechanisms of diabetic atherosclerosis

  Goedeke, L.

  National Heart, Lung, and Blood Institute

  15/12/19 → 30/11/20

  Project: Research

  • Atherosclerosis 100%
  • Insulin Resistance 55%
  • Liver 52%
  • Macrophages 47%
  • Mentors 42%

• Auxetic Ventricular Support Device for Chronic Myocardial Infarction

  Costa, K. & Xu, J.

  National Institute of Biomedical Imaging and Bioengineering

  1/08/19 → 31/05/21

  Project: Research

  • Myocardial Infarction 100%
  • Equipment and Supplies 78%
  • Ventricular Remodeling 67%
  • Infarction 63%
  • Heart-Assist Devices 44%

• DEGENERATIVE CARDIOVASCULAR DISEASE RISKS DUE TO SINGLE HZE OR MIXED ION RADIATION

  Goukassian, D.

  Johnson Space Center

  10/04/19 → 9/04/20

  Project: Research

  • Radiation 100%
  • Cardiovascular Diseases 87%
  • Ions 80%
  • Space Research 45%
  • Heavy Ions 39%

• An RNA-based approach to intranasal delivery of neuropeptides to the brain

  Zangi, L. & Harony-Nicolas, H.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  1/03/19 → 31/12/21

  Project: Research

  • Neuropeptides 100%
  • RNA 55%
  • Brain 42%
  • Mood Disorders 27%
  • Intranasal Administration 24%

• Studying Atherosclerosis Macrophage Dynamics by Combined PET and Fluorine-MRI

  Fayad, Z. & Fayad, Z. A.

  National Heart, Lung, and Blood Institute

  15/01/19 → 31/12/22

  Project: Research

  • Fluorine 100%
  • Atherosclerosis 61%
  • Macrophages 50%
  • Magnetic Resonance Imaging 47%
  • Positron-Emission Tomography 42%

• Inhibition of trained immunity in atherosclerosis and ischemic heart disease.

  van Leent, M.

  American Heart Association

  1/01/19 → 31/12/20

  Project: Research

  • Myocardial Ischemia 100%
  • Immunity 92%
  • Atherosclerosis 91%
  • HDL Lipoproteins 79%
  • Epigenomics 65%

• Sleep controls hematopoiesis and regulates atherosclerosis: a novel neuro-immune axis

  McAlpine, C. & Swirski, F.

  Institute of Circulatory and Respiratory Health

  1/09/18 → 31/12/20

  Project: Research

  • Neuroimmunomodulation 100%
  • Sleep 99%
  • Hematopoiesis 75%
  • Atherosclerosis 55%
  • Leukocytes 44%

• Sleep controls hematopoiesis and regulates atherosclerosis: a novel neuro-immune axis

  McAlpine, C.

  Institute of Circulatory and Respiratory Health

  1/09/18 → 31/08/20

  Project: Research

  • Neuroimmunomodulation 100%
  • Sleep 99%
  • Hematopoiesis 75%
  • Atherosclerosis 55%
  • Leukocytes 44%

• TRAF6 Nanoimmunotherapy to resolve plaque inflammation

  Fayad, Z. & Mulder, W.

  National Heart, Lung, and Blood Institute

  15/08/18 → 30/06/20

  Project: Research

  • TNF Receptor-Associated Factor 6 100%
  • HDL Lipoproteins 82%
  • Primates 41%
  • Inflammation 39%
  • Apolipoproteins E 35%

• MerTK in NASH-related liver fibrosis

  Cai, B.

  National Institute of Diabetes and Digestive and Kidney Diseases

  16/07/18 → 15/07/20

  Project: Research

  • Non-alcoholic Fatty Liver Disease 100%
  • Liver Cirrhosis 64%
  • Fibrosis 47%
  • Hepatic Stellate Cells 33%
  • Tretinoin 18%

• Extracellular vesicles secreted by human Induced Pluripotent Stem Cells (iPSC)-derived Vascular Cells as Novel Biomarker

  Hadri, L.

  American Heart Association

  1/07/18 → 30/06/20

  Project: Research

  • Extracellular Vesicles 100%
  • Pulmonary Arterial Hypertension 82%
  • Bone Morphogenetic Protein Receptors 73%
  • Induced Pluripotent Stem Cells 63%
  • Bone Morphogenetic Protein 2 63%

• SPACE RELEVANT RADIATION-INDUCED CARDIOVASCULAR DISEASE RISK THRESHOLDS: EFFECT OF GENDER ON THE OUTCOME

  Goukassian, D.

  Johnson Space Center

  10/05/18 → 17/10/18

  Project: Research

  • Radio 100%
  • Radiation 88%
  • Oxidative Stress 71%
  • Space Flight 62%
  • Asymptomatic Diseases 62%

• Novel Selective Type II kinase Inhibitors to treat Diabetes

  DeVita, R., Stewart, A., Devita, R. J. & Stewart, A. F.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/18 → 28/02/23

  Project: Research

  • Phosphotransferases 100%
  • National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) 92%
  • Cell Proliferation 41%
  • Pharmaceutical Chemistry 34%
  • Computational Chemistry 27%

• Epigenetic Control of Human Beta Cell Proliferation

  Stewart, A., Argmann, C., Scott, D. & Walsh, M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/18 → 31/03/19

  Project: Research

  • Epigenomics 100%
  • Insulinoma 96%
  • Cell Proliferation 78%
  • Chromosomes, Human, Pair 11 49%
  • Pancreatic adenoma 23%

• Defining the spatio-temporal mechanisms of ventricular cell specification and differentiation

  DuBois, N.

  National Heart, Lung, and Blood Institute

  15/02/18 → 31/01/22

  Project: Research

  • Pluripotent Stem Cells 100%
  • Cell Differentiation 97%
  • Cardiac Myocytes 47%
  • Heart Diseases 27%
  • Heart 22%

• Dysregulated Adenosine Methylation of mRNA as a Novel Mechanism of Heart Failure

  Sahoo, S.

  National Heart, Lung, and Blood Institute

  15/01/18 → 30/11/21

  Project: Research

  • Methylation 100%
  • Adenosine 99%
  • Heart Failure 75%
  • Messenger RNA 68%
  • Fats 58%

• INTERLEUKIN-3 IN ALZHEIMER'S DISEASE

  Swirski, F.

  Cure Alzheimer's Fund

  1/01/18 → 31/12/19

  Project: Research

  • Interleukin-3 100%
  • Microglia 64%
  • Alzheimer Disease 49%
  • Symptom Flare Up 24%
  • Amyloid beta-Peptides 23%

• Effect of Liver-Specific Acetyl-CoA Carboxylase Inhibition on Hepatic Steatosis and Insulin Resistance

  Goedeke, L.

  National Institute of Diabetes and Digestive and Kidney Diseases

  8/12/17 → 7/12/19

  Project: Research

  • fatty liver 100%
  • acetyl-CoA carboxylase 98%
  • insulin resistance 96%
  • liver 59%
  • hypertriglyceridemia 17%

• Morphogenetic Self-Assembly of Human Heart Organoids

  Sachs, D. & Costa, K.

  National Institute of Biomedical Imaging and Bioengineering

  6/09/17 → 30/06/20

  Project: Research

  • Organoids 100%
  • Heart 57%
  • Bioreactors 46%
  • Bioengineering 25%
  • Microfluidics 23%

• Combined harmalog-tgf beta inhibitors for human beta cell expansion

  Stewart, A.

  Juvenile Diabetes Research Foundation United States of America

  1/09/17 → 31/08/19

  Project: Research

  • Pharmaceutical Preparations 100%
  • Harmine 80%
  • Drive 49%
  • Pancreas 41%
  • Regeneration 40%

• Effect of Liver Specific Acetyl-CoA Carboxylase Inhibition on Hepatic Steatosis and Insulin Resistance

  Goedeke, L.

  American Heart Association

  1/07/17 → 7/12/17

  Project: Research

  • fatty liver 100%
  • insulin resistance 90%
  • acetyl-CoA carboxylase 87%
  • liver 61%
  • noninsulin-dependent diabetes mellitus 18%