Cancer Mechanisms

273232 Citations
237 h-index
2339 Article
404 Review article
206 Comment/debate
141 Editorial
More

Acting on Dormancy: The Interplay Between the Actin Cytoskeleton and Tumor Cell Dormancy
Sabol, H. M., Bravo-Cordero, J. J. & Borriello, L., 15 Apr 2026, In: Cancer Research. 86, 8, p. 1820-1822 3 p.
Research output: Contribution to journal › Article › peer-review
A gated hydrophobic funnel within BAX binds bioactive lipids to potentiate pro-apoptotic function
Gelles, J. D., Chen, Y., Luna-Vargas, M. P. A., Viacava Follis, A., Al Noman, M. A., Kabir, M., Bayiokos, S. G., Mohammed, J. N., Sebastian, T. M., Pham, N. D., Shi, Y., Jin, J., Kriwacki, R. W. & Chipuk, J. E., Dec 2026, In: Nature Communications. 17, 1, 3180.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
AhR inhibition promotes axon regeneration via a stress–growth switch
Halawani, D., Wang, Y., Li, J., Halperin, D., Ni, H., Estill, M., Ramakrishnan, A., Shen, L., Sefiani, A., Geoffroy, C. G., Friedel, R. H. & Zou, H., 2026, (Accepted/In press) In: Nature.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Scopus citations
Allele specific expression in Alzheimer's disease
Wang, Z., Hossain, D., Wang, J. J., Subramaniam, V. R., Zhang, B., Wang, M. & Huang, K. L., Jun 2026, In: Alzheimer's and Dementia. 22, 6, e71558.
Research output: Contribution to journal › Article › peer-review

Open Access
Allosteric Inhibition of PKMYT1 Induces a Unique, Inactive ATP Binding Site Conformation
Herrington, N. B., Khamrui, S., Zhao, Y., Lansiquot, C., Wu, R., Pandey, G., Lazarus, M. B. & Schlessinger, A., 17 Jun 2026, In: Journal of the American Chemical Society. 148, 23, p. 24274-24286 13 p.
Research output: Contribution to journal › Article › peer-review
A MICA/B GAALIE-mutant antibody elicits potent natural killer cell-driven immunity in solid and hematologic malignancy models
Pimenta, R., Maurer, S., Zhong, X., Taciane da Silva Bortoleti, B., Quasem, S., Ribeiro de Lima Brandão, L., Marcellino, B., Dutta, A., Arriaga, J. M., Mascarenhas, J. & Ferrari de Andrade, L., 19 May 2026, In: Cell Reports Medicine. 7, 5, 102753.
Research output: Contribution to journal › Article › peer-review

Open Access
A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms
Fu, T. M., Liu, G., Milkie, D. E., Ruan, X., Görlitz, F., Shi, Y., Ferro, V., Divekar, N. S., Wang, W., York, H. M., Kilic, V., Mueller, M., Liang, Y., Daugird, T. A., Gacha-Garay, M. J., Larkin, K. A., Adikes, R. C., Harrison, N., Shirazinejad, C. & Williams, S. & 29 others, Nourse, J. L., Sheu, S. H., Gao, L., Li, T., Mondal, C., Achour, K., Hercule, W., Stabley, D. R., Emmerich, K., Dong, P., Drubin, D. G., Liu, Z. J., Mumm, J. S., Koyama, M., Killilea, A. N., Bravo-Cordero, J. J., Keene, C. D., Luo, L., Kirchhausen, T., Pathak, M. M., Arumugam, S., Nuñez, J. K., Gao, R., Matus, D. Q., Martin, B. L., Swinburne, I. A., Betzig, E., Legant, W. R. & Upadhyayula, S., Jun 2026, In: Nature Methods. 23, 6, p. 1184-1195 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Anti-FAP CAR T cells produced in vivo reduce fibrosis and restore liver homeostasis in metabolic dysfunction–associated steatohepatitis
Yashaswini, C. N., Cogliati, B., Qin, T., To, T., Williamson, T., Papp, T. E., Li, K., Rasul, R., Chen, L., Lightstone, A., Aghajanian, H., Parhiz, H., Wang, S., Rurik, J. G., Epstein, J. A. & Friedman, S. L., 21 Jan 2026, In: Science Translational Medicine. 18, 833, eadx0368.
Research output: Contribution to journal › Article › peer-review
12 Scopus citations
A Recombinant Antibody Against Human DRP1 Serine 616 Phosphorylation Enables Detection of BRAF^V600E-Associated Mitochondrial Division in Cancer
Nizard, S. T., Chen, Y., Serasinghe, M. N., Fernandez-Rodriguez, R., Shultz, K. D., Khatun, J., Mendoza, A., Gelles, J. D., Henao-Martinez, J. F., Abraham-Enachescu, I., Noman, M. A. A., Bayiokos, S. G., Duty, J. A., Meehan, S., Skobe, M. & Chipuk, J. E., Apr 2026, In: Antibodies. 15, 2, 38.
Research output: Contribution to journal › Article › peer-review

Open Access
Association of Race/Ethnicity with Diabetes Medication Beliefs and Self-Management Behaviors in Breast Cancer Survivors
Leiter, A., Sanghavi Goel, M., Harris, Y. T., Doron, E., Gallagher, E. J., LeRoith, D., Wisnivesky, J. P. & Lin, J. J., 2026, (Accepted/In press) In: Journal of Women's Health.
Research output: Contribution to journal › Article › peer-review
A synergistic interaction between PRMT5 and LSD1 inhibitors in AML
Param, N. J., Arceci, E., Fiorentino, F., Pignata, L., Torre, D., Gutiérrez-Trejo, N., Fong, J. Y., Goy, P. A., Han, B. Y., Lambona, C., Bello, E. D., Castiello, C., Barone, M., Schwarz, M., Arrowsmith, C., Ito, K., Scherle, P., Wee, D. K. B., Ndoye, S. & Tabaglio, T. & 9 others, Jeyasekharan, A. D., Lakshmanan, M., Cirilli, R., Habisch, H., Madl, T., Mattevi, A., Valente, S., Mai, A. & Guccione, E., 27 Mar 2026, In: Science advances. 12, 13, eaea4059.
Research output: Contribution to journal › Article › peer-review

Open Access
A tumor-selective mRNA system enables precision cancer treatment
Żak, M. M., Yoo, J., Utrero-Rico, A., Walter, W., Mainkar, G., Adjmi, M., Kurian, A. A., Rahaman, A., Ojalvo, D. L., Ochando, J., Haferlach, T., Parsons, R. E., Swirski, F. K. & Zangi, L., 4 Feb 2026, In: Molecular Therapy. 34, 2, p. 1066-1083 18 p.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Scopus citations

New Drug Research Findings from Icahn School of Medicine at Mount Sinai Reported (Structural and biochemical insight into allosteric regulation of the human 2-aminoadipic semialdehyde synthase, a bifunctional enzyme involved in lysine catabolism)
Houten, S., Lazarus, M. & Osman, R.
1/07/26
1 item of Media coverage
Press/Media
Findings from Icahn School of Medicine at Mount Sinai in Polyomavirus Provides New Insights (Mouse model of Merkel cell carcinoma derived from the hair follicle)
Ezhkova, E.
1/07/26
1 item of Media coverage
Press/Media
HMN 2026: How AI misses cancer drug target, revealing why lab validation still matters
Schlessinger, A. & Lazarus, M.
19/06/26
1 item of Media coverage
Press/Media
New Science Study Findings Recently Were Reported by Researchers at Stanford University School of Medicine (Electrophysiological Brain Connectivity and Subjective States Evoked by Electrical Stimulation of the Human Mid-thalamus)
Fisher, R.
17/06/26
1 item of Media coverage
Press/Media
Studies in the Area of Clinical Oncology Reported from Icahn School of Medicine at Mount Sinai (Allosteric Inhibition of PKMYT1 Induces a Unique, Inactive ATP Binding Site Conformation)
Schlessinger, A. & Lazarus, M.
17/06/26
1 item of Media coverage
Press/Media
A tiny bacterium in your blood could change the future of anti-aging and longevity. What does it do?
Ghaffari, S.
15/06/26 → 16/06/26
2 items of Media coverage
Press/Media
Age-Related Mutations in Brain Immune Cells Linked to Alzheimer’s Inflammation
Papapetrou, E. & Marro, S.
13/06/26
1 item of Media coverage
Press/Media
Cancer-Associated Mutations in Brain Immune Cells May Contribute to Alzheimer's Disease
Papapetrou, E. & Marro, S.
11/06/26 → 13/06/26
6 items of Media coverage
Press/Media
Researchers at Weill Cornell Medicine Target Nucleoproteins (Single-cell mapping of regulatory DNA-protein interactions)
Izzo, F.
12/06/26
1 item of Media coverage
Press/Media
Mount Sinai Scientists Reverse Aging in Blood Stem Cells by Fixing the Cell's Recycling System
Ghaffari, S.
12/06/26
1 item of Media coverage
Press/Media
Reports Summarize Nanobodies Findings from Icahn School of Medicine at Mount Sinai (Multispecific nanobody degraders co-deplete membrane receptors and enable targeted delivery of diverse payloads)
Kabir, M., Zhong, Y., Huang, K. & Guccione, E.
11/06/26
1 item of Media coverage
Press/Media
Researchers from Baylor College of Medicine Report on Findings in Breast Cancer (NF1 loss in estrogen receptor-positive breast cancer induces osteoclast formation and immunosuppression to promote bone metastasis)
Bado, I.
11/06/26
1 item of Media coverage
Press/Media

Cancer Mechanisms

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

Stuart Aaronson

Aneel Aggarwal

Juan Arriaga

Igor Bado

Emily Bernstein

James Bieker

Anne Bowcock

Jose Javier Bravo-Cordero

Goutam Chakraborty

Jerry Chipuk

Jaime Chu

David Dominguez-Sola

Acting on Dormancy: The Interplay Between the Actin Cytoskeleton and Tumor Cell Dormancy

A gated hydrophobic funnel within BAX binds bioactive lipids to potentiate pro-apoptotic function

AhR inhibition promotes axon regeneration via a stress–growth switch

Allele specific expression in Alzheimer's disease

Allosteric Inhibition of PKMYT1 Induces a Unique, Inactive ATP Binding Site Conformation

A MICA/B GAALIE-mutant antibody elicits potent natural killer cell-driven immunity in solid and hematologic malignancy models

A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms

Anti-FAP CAR T cells produced in vivo reduce fibrosis and restore liver homeostasis in metabolic dysfunction–associated steatohepatitis

A Recombinant Antibody Against Human DRP1 Serine 616 Phosphorylation Enables Detection of BRAF^V600E-Associated Mitochondrial Division in Cancer

Association of Race/Ethnicity with Diabetes Medication Beliefs and Self-Management Behaviors in Breast Cancer Survivors

A synergistic interaction between PRMT5 and LSD1 inhibitors in AML

A tumor-selective mRNA system enables precision cancer treatment

New Drug Research Findings from Icahn School of Medicine at Mount Sinai Reported (Structural and biochemical insight into allosteric regulation of the human 2-aminoadipic semialdehyde synthase, a bifunctional enzyme involved in lysine catabolism)

Findings from Icahn School of Medicine at Mount Sinai in Polyomavirus Provides New Insights (Mouse model of Merkel cell carcinoma derived from the hair follicle)

HMN 2026: How AI misses cancer drug target, revealing why lab validation still matters

New Science Study Findings Recently Were Reported by Researchers at Stanford University School of Medicine (Electrophysiological Brain Connectivity and Subjective States Evoked by Electrical Stimulation of the Human Mid-thalamus)

Studies in the Area of Clinical Oncology Reported from Icahn School of Medicine at Mount Sinai (Allosteric Inhibition of PKMYT1 Induces a Unique, Inactive ATP Binding Site Conformation)

A tiny bacterium in your blood could change the future of anti-aging and longevity. What does it do?

Age-Related Mutations in Brain Immune Cells Linked to Alzheimer’s Inflammation

Cancer-Associated Mutations in Brain Immune Cells May Contribute to Alzheimer's Disease

Researchers at Weill Cornell Medicine Target Nucleoproteins (Single-cell mapping of regulatory DNA-protein interactions)

Mount Sinai Scientists Reverse Aging in Blood Stem Cells by Fixing the Cell's Recycling System

Reports Summarize Nanobodies Findings from Icahn School of Medicine at Mount Sinai (Multispecific nanobody degraders co-deplete membrane receptors and enable targeted delivery of diverse payloads)

Researchers from Baylor College of Medicine Report on Findings in Breast Cancer (NF1 loss in estrogen receptor-positive breast cancer induces osteoclast formation and immunosuppression to promote bone metastasis)

Cancer Mechanisms

Fingerprint

Collaborations and top research areas from the last five years

Profiles

Research output

Press/Media