Cancer Clinical Investigation

Projects

Projects per year 1984 2004 2005 2015 2016 2017 2019 2020 2021 2023

• 79 Active
• 127 Finished

Projects per year

Search results

• Finished

  A Cytochrome P450 Therapeutic Space for Tauopathies

  Dar, A. & Cagan, R.

  National Institute on Aging

  30/09/21 → 31/08/22

  Project: Research

  • Anastrozole 100%
  • cytochrome P-450 92%
  • Tauopathies 80%
  • therapeutics 76%
  • neurodegenerative diseases 62%

• Identifying the Long-Term Neurological Effects of COVID-19 Using 7 Tesla Multi-Modal MRI

  Balchandani, P.

  National Institute of Neurological Disorders and Stroke

  1/04/21 → 30/09/22

  Project: Research

  • Neurologic Manifestations 100%
  • Brain 38%
  • Neuroimaging 35%
  • SARS Virus 29%
  • Olfaction Disorders 28%

• A Chemical Genetic Approach to Exploring Novel Therapeutic Space for Colorectal Cancer

  Dar, A., Cagan, R., Dar, A. & Cagan, R. R. L.

  National Cancer Institute

  1/03/21 → 28/02/23

  Project: Research

  • regorafenib 100%
  • Phosphotransferases 62%
  • Colorectal Neoplasms 60%
  • Polypharmacology 20%
  • Aurora Kinase A 17%

• Illuminating the Druggable Genome Data Coordinating Center - Engagement Plan with the CFDE

  Lambert, C. C. G., Ma’ayan, A., Ma'ayan, A. & Oprea, T. I.

  NIH Office of the Director

  23/09/20 → 22/09/22

  Project: Research

  • Genomics 100%
  • Proteins 48%
  • Genes 43%
  • Landing 14%
  • Pathology 8%

• Cross-correlation of biomechanical, connectomic, and pathologic markers in Alzheimer's disease at 7T MRI

  Balchandani, P. & Kurt, M.

  National Institute on Aging

  15/09/20 → 31/08/22

  Project: Research

  • Elasticity Imaging Techniques 100%
  • Connectome 76%
  • Neuroimaging 37%
  • Alzheimer Disease 37%
  • Brain 33%

• Biological and Medicinal Chemistry Approaches to Human Beta Cell Regeneration

  Stewart, A., DeVita, R. & García-Ocaña, A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/07/20 → 31/03/22

  Project: Research

  • Chemistry 100%
  • Molecule 85%
  • Agent Interacting With Transmitter, Hormone or Drug Receptor 63%
  • Exendin-4 34%
  • Harmine 30%

• LEAP-HI: Tackling Brain Diseases with Mechanics: A Data-Driven Approach to Merge Advanced Neuroimaging and Multi-Physics Modeling

  Kurt, M. M., Zhang, Y. Y. J., Weickenmeier, J. J. & Balchandani, P.

  National Science Foundation

  1/07/20 → 31/05/22

  Project: Research

  • Brain 100%
  • Neuroimaging 94%
  • Mechanics 72%
  • Physics 58%
  • Health 52%

• Development of a multi-omic clinical decision platform to guide personalized therapy

  Parekh, S. & Parekh, S.

  National Cancer Institute

  6/02/20 → 31/01/23

  Project: Research

  • Multiple Myeloma 100%
  • Drug Repositioning 51%
  • Big Data 50%
  • RNA Sequence Analysis 41%
  • Therapeutics 32%

• Enhancing natural killer cell recognition of leukemic cells

  Marcellino, B.

  Leukemia Research Foundation

  1/01/20 → 31/12/21

  Project: Research

  • Natural Killer Cells 100%
  • Acute Myeloid Leukemia 46%
  • Antibodies 18%
  • Drug Combinations 16%
  • Membrane Proteins 13%

• Genomic and Transcriptomic Analysis of Mammographic Density

  Sieh, W., Habel, L. A., Habel, L. L. A., Wang, P. P., Sieh, W. & Wang, P.

  National Cancer Institute

  11/12/19 → 30/11/22

  Project: Research

  • Breast Density 100%
  • Genes 69%
  • Genomics 34%
  • Genome-Wide Association Study 31%
  • Gene expression 28%

• Role of the K27M histone mutation in midline gliomas initiated in oligodendrocyte progenitors

  Becher, O.

  National Institute of Neurological Disorders and Stroke

  1/12/19 → 30/11/21

  Project: Research

  • Diffuse Intrinsic Pontine Glioma 100%
  • Oligodendrocyte Precursor Cells 83%
  • Histones 51%
  • Glioma 50%
  • Mutation 35%

• Targeting the Microbiome to Enable Immunotherapeutic Efficacy in Pancreatic Carcinoma

  Cohen, D.

  U.S. Army

  30/09/19 → 30/09/19

  Project: Research

  • Microbiota 100%
  • Adenocarcinoma 79%
  • Pancreatic Carcinoma 67%
  • Immunotherapy 39%
  • Clinical Trials 21%

• DISSECTION OF SUPPRESSIVE AXES UNDERLYING NATURAL KILLER CELL DYSFUNCTION IN HUMAN BLADDER CANCER

  Sfakianos, J.

  Congressionally Directed Medical Research Programs

  15/07/19 → 14/07/22

  Project: Research

  • Natural Killer Cells 100%
  • Urinary Bladder Neoplasms 67%
  • Dissection 50%
  • Neoplasms 35%
  • Tumor Microenvironment 12%

• Dissection of Suppressive Axes Underlying Natural Killer Cell Dysfunction in Human Bladder Cancer

  Bhardwaj, N.

  U.S. Army

  15/07/19 → 15/07/19

  Project: Research

  • Urinary Bladder Neoplasms 100%
  • Natural Killer Cells 96%
  • Dissection 54%
  • Neoplasms 38%
  • Veterans 18%

• Dissection of Suppressive Axes Underlying Natural Killer Cell Dysfunction in Human Bladder Cancer

  Sfakianos, J.

  U.S. Army

  15/07/19 → 15/07/19

  Project: Research

  • Urinary Bladder Neoplasms 100%
  • Natural Killer Cells 96%
  • Dissection 89%

• DISSECTION OF SUPPRESSIVE AXES UNDERLYING NATURAL KILLER CELL DYSFUNCTION IN HUMAN BLADDER CANCER

  Bhardwaj, N.

  Congressionally Directed Medical Research Programs

  15/07/19 → 14/07/22

  Project: Research

  • Natural Killer Cells 100%
  • Urinary Bladder Neoplasms 67%
  • Dissection 50%
  • Neoplasms 35%
  • Tumor Microenvironment 12%

• Clinical Protocol & Data Management (CPDM)

  Sparano, J. J. A. & Sparano, J.

  National Cancer Institute

  1/07/19 → 30/06/22

  Project: Research

  • Data Management 100%
  • Clinical Protocols 74%
  • Early Detection of Cancer 20%
  • Neoplasms 17%
  • Clinical Trials Data Monitoring Committees 16%

• Molecular Cytogenetics

  Morrow, B. B. & Sparano, J.

  National Cancer Institute

  1/07/19 → 30/06/22

  Project: Research

  • Cytogenetics 100%
  • Genome 45%
  • Spectral Karyotyping 27%
  • Chromosomes 26%
  • Research Personnel 23%

• Dysregulated iron metabolism plays a pivotal role in polycythemia vera

  Ginzburg, Y.

  MPN Research Foundation

  1/01/19 → 31/12/21

  Project: Research

• Novel tumoral and immunoregulatory roles for ptk6 in TNBC metastasis

  Irie, H.

  American Cancer Society

  1/07/18 → 30/06/22

  Project: Research

• Targeting Oncogenic Ras-MAPK Signaling Complexes via the Scaffold KSR

  Dar, A. & Dar, A.

  National Cancer Institute

  15/03/18 → 28/02/23

  Project: Research

  • Mitogen-Activated Protein Kinases 100%
  • Phosphotransferases 76%
  • Neoplasms 24%
  • Protein Kinase Inhibitors 18%
  • Therapeutic Index 13%

• Project 4: MPN-RC Clinical Consortium

  Mascarenhas, J. & Mascarenhas, J.

  National Cancer Institute

  1/03/18 → 28/02/23

  Project: Research

  • Primary Myelofibrosis 100%
  • Hematopoietic Stem Cells 85%
  • Neoplasms 60%
  • Clinical Trials, Phase I 42%
  • Bone Marrow 25%

• Patient-Specific Mutation-Derived Tumor Neoantigens as Targets for Cancer Immunotherapy in Smoldering Multiple Myeloma

  Parekh, S.

  National Cancer Institute

  1/01/18 → 31/12/19

  Project: Research

  • Smoldering Multiple Myeloma 100%
  • Multiple Myeloma 79%
  • Immunotherapy 51%
  • Mutation 43%
  • T-Lymphocytes 31%

• Prediction of portal pressure with liver and spleen MR Elastography and 4D flow phase-contrast MRI

  Taouli, B.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/12/17 → 30/11/21

  Project: Research

  • Portal Pressure 100%
  • Portal Hypertension 96%
  • Elasticity Imaging Techniques 90%
  • Spleen 59%
  • Magnetic Resonance Imaging 51%

• Novel Treatment Options for Glutaric Aciduria

  Houten, S. & DeVita, R.

  National Institute of Child Health and Human Development

  1/09/17 → 31/08/19

  Project: Research

  • Glutaryl-CoA Dehydrogenase 100%
  • Pharmaceutical Chemistry 74%
  • 3-hydroxyglutaric acid 68%
  • glutaric acid 61%
  • Lysine 52%

• TARGETING PROLIFERATIVE AND DRUG RESISTANCE PATHWAYS IN TRIPLE-NEGATIVE BREAST CANCER STEM CELLS

  Irie, H.

  Congressionally Directed Medical Research Programs

  15/08/17 → 14/08/20

  Project: Research

  • Triple Negative Breast Neoplasms 100%
  • Neoplastic Stem Cells 83%
  • Breast Neoplasms 55%
  • Drug Resistance 43%
  • Heterografts 42%

• Military medical research and development

  Irie, H.

  U.S. Army

  15/08/17 → 14/08/20

  Project: Research

  • Proliferative 100%
  • Phosphotransferase Inhibitor 94%
  • Triple Negative Breast Neoplasms 90%
  • Paclitaxel 90%
  • Neoplastic Stem Cells 79%

• Military medical research and development

  Galsky, M.

  U.S. Army

  1/08/17 → 31/07/19

  Project: Research

  • Circulating Neoplastic Cells 100%
  • Urinary Bladder Neoplasms 77%
  • Heterografts 72%
  • Biomedical Research 40%
  • Therapeutics 13%

• CIRCULATING TUMOR CELL-BASED PATIENT-DERIVED XENOGRAFT MODELS OF METASTATIC BLADDER CANCER AS A PLATFORM FOR DEVELOPMENT OF NOVEL THERAPEUTIC APPROACHES

  Galsky, M.

  Congressionally Directed Medical Research Programs

  1/08/17 → 31/07/19

  Project: Research

  • Circulating Neoplastic Cells 100%
  • Urinary Bladder Neoplasms 68%
  • Heterografts 66%
  • Cisplatin 63%
  • DNA Damage 22%

• A network-based approach for personalized treatment of Multiple Myeloma

  Parekh, S.

  National Cancer Institute

  6/07/17 → 30/06/19

  Project: Research

  • Personalized medicine 100%
  • Oncology 30%
  • Aberrations 30%
  • Biological systems 26%
  • Large dataset 25%

• PTK6 promotes metastasis, chemoresistance and altered immuno-profiles of TNBC

  Irie, H.

  Susan G. Komen

  1/01/17 → 31/12/18

  Project: Research

• Mechanism-based strategies to target oncogenic BRAF signaling

  Poulikakos, P.

  National Cancer Institute

  8/12/16 → 30/11/21

  Project: Research

  • Proto-Oncogene Proteins B-raf 100%
  • Melanoma 76%
  • Dimerization 69%
  • Mitogen-Activated Protein Kinase Kinases 66%
  • Neoplasms 59%

• 7T MRI to reveal structural, connectomic and metabolic imaging markers for the neurobiology of depression

  Balchandani, P.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  23/09/16 → 30/06/21

  Project: Research

  • Connectome 100%
  • Major Depressive Disorder 86%
  • Neurobiology 81%
  • Magnetic Resonance Imaging 50%
  • Depression 45%

• MECHANISM OF ACQUIRED RESISTANCE TO SORAFENIB IN HCC

  Llovet, J.

  Congressionally Directed Medical Research Programs

  1/09/16 → 31/08/19

  Project: Research

  • Sorafenib 100%
  • Hepatocellular Carcinoma 56%
  • Organoids 19%
  • Veterans 12%
  • Heterografts 10%

• Mechanisms of Acquired Resistance to Sorafenib in Hepatocellular Carcinoma

  Villanueva Rodriguez, A.

  U.S. Army

  1/09/16 → 1/09/16

  Project: Research

  • Sorafenib 100%
  • Hepatocellular Carcinoma 43%
  • Neoplasms 27%
  • Drug Combinations 22%
  • Drug Resistance 19%

• Mechanism of Acquired Resistance to Sorafenib in HCC

  Llovet, J.

  U.S. Army

  1/09/16 → 1/09/16

  Project: Research

  • Sorafenib 100%
  • Neoplasms 27%
  • Drug Combinations 22%
  • Drug Resistance 19%
  • Animal Models 15%

• MECHANISMS OF ACQUIRED RESISTANCE TO SORAFENIB IN HEPATOCELLULAR CARCINOMA

  Villanueva Rodriguez, A.

  Congressionally Directed Medical Research Programs

  1/09/16 → 31/08/19

  Project: Research

  • Sorafenib 100%
  • Hepatocellular Carcinoma 56%
  • Organoids 19%
  • Veterans 12%
  • Heterografts 10%

• Effect of SARS-CoV-2 on clinical course and NK cells in patients receiving immunotherapy

  Bhardwaj, N.

  National Cancer Institute

  27/07/16 → 30/06/21

  Project: Research

  • Natural Killer Cells 100%
  • Melanoma 69%
  • SARS Virus 34%
  • Immunotherapy 23%
  • Neoplasms 16%

• Core 3: Pathology, Clinical Database, Sample Repository and Biomarkers

  Levine, J.

  National Cancer Institute

  1/07/16 → 31/08/21

  Project: Research

  • Clinical Pathology 100%
  • Pathology 59%
  • Biomarkers 56%
  • Databases 54%
  • Clinical Trials 30%

• Project 3: Clinical Trials of High Risk GVHD

  Levine, J.

  National Cancer Institute

  1/07/16 → 31/08/21

  Project: Research

  • Graft vs Host Disease 100%
  • Clinical Trials 52%
  • Mortality 15%
  • Natalizumab 11%
  • Gastrointestinal Tract 10%

• Endothelial cell-derived MMP14 in lung alveolar regeneration and fibrosis

  Powell, C. & Ding, B.

  National Heart, Lung, and Blood Institute

  1/05/16 → 31/08/21

  Project: Research

  • Regeneration 100%
  • Fibrosis 90%
  • Endothelial Cells 90%
  • Lung 71%
  • Blood Platelets 28%

• 7T Neurosurgical Mapping Protocol for Endoscopic Resection of Skull Base Tumors

  Balchandani, P.

  National Cancer Institute

  13/04/16 → 31/03/21

  Project: Research

  • Tumors 100%
  • Imaging techniques 80%
  • Magnetic resonance 39%
  • Planning 28%
  • Surgery 22%

• DEVELOPMENT OF SMALL MOLECULE ACTIVATORS OF PROTEIN PHOSPHATASE 2A (SMAPS) FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER

  Galsky, M.

  Congressionally Directed Medical Research Programs

  30/09/15 → 29/09/18

  Project: Research

  • Protein Phosphatase 2 100%
  • Prostatic Neoplasms 63%
  • Castration 63%
  • Androgen Receptors 60%
  • Lead 19%

• Development of Small Molecule Activators of Protein Phosphatase 2A (SMAPs) for the Treatment of Castration-Resistant Prostate Cancer

  Galsky, M.

  U.S. Army

  30/09/15 → 30/09/15

  Project: Research

  • Protein Phosphatase 2 100%
  • Prostatic Neoplasms 79%
  • Castration 63%
  • Pharmaceutical Preparations 41%
  • Androgen Receptors 14%

• The Role of Erythroferrone in Regulating Bone Metabolism in Beta-Thalassemia

  Ginzburg, Y., Ginzburg, Y., Zaidi, M. & Yuen, T.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/09/15 → 31/01/23

  Project: Research

  • Erythropoiesis 100%
  • Iron 71%
  • Transferrin Receptors 57%
  • Transferrin 50%
  • Hepcidins 34%

• Integrative informatics approach to develop safe glucocorticoid therapies

  Budunova, I., Dudley, J. & Ma’ayan, A.

  National Institute of General Medical Sciences

  15/08/15 → 30/04/21

  Project: Research

  • Informatics 100%
  • Glucocorticoids 85%
  • Glucocorticoid Receptors 68%
  • Skin 42%
  • Atrophy 40%

• Cancer Immunology (CI) (Project-001)

  Bhardwaj, N.

  National Cancer Institute

  1/08/15 → 31/07/20

  Project: Research

  • Allergy and Immunology 100%
  • Neoplasms 33%
  • Dendritic Cells 15%
  • Immunotherapy 10%
  • Macrophages 7%

• PROTOCOL REVIEW AND MONITORING SYSTEM (Core-008)

  Schwartz, M.

  National Cancer Institute

  1/08/15 → 31/07/20

  Project: Research

  • protocols 100%
  • monitoring 84%
  • committees 73%
  • neoplasms 32%
  • focus groups 10%

• Novel Approach to Facilitate Decisions in Patients w/ Muscle Invasive Bladder CA

  Diefenbach, M. A. & Galsky, M.

  National Cancer Institute

  1/05/15 → 30/04/16

  Project: Research

  • Urinary Bladder Neoplasms 100%
  • Urinary Bladder 93%
  • Physicians 75%
  • Pamphlets 73%
  • Muscles 70%

• Data Organization Core

  Dudley, J. & Ma’ayan, A.

  National Cancer Institute

  1/08/14 → 31/07/16

  Project: Research

  • Proteins 100%
  • Genes 52%
  • Genomics 37%
  • Molecules 35%
  • Cytoplasmic and Nuclear Receptors 34%