Cancer Biology

Projects

Projects per year 1985 2009 2011 2014 2015 2016 2017 2018 2020 2021 2023

• 36 Active
• 103 Finished

Projects per year

Search results

• Finished

  A Cytochrome P450 Therapeutic Space for Tauopathies

  Dar, A. & Cagan, R.

  National Institute on Aging

  30/09/21 → 31/08/22

  Project: Research

  • Anastrozole 100%
  • cytochrome P-450 92%
  • Tauopathies 80%
  • therapeutics 76%
  • neurodegenerative diseases 62%

• FUNCTIONAL CHARACTERIZATION OF NOVEL DETERMINANTS OF HOLOPROSENCEPHALY (HPE)

  Guccione, E.

  National Institute of Child Health and Human Development

  5/03/21 → 28/02/22

  Project: Research

  • Holoprosencephaly 100%
  • Microcephaly 45%
  • Epigenomics 24%
  • Mutation 20%
  • Prosencephalon 19%

• A Chemical Genetic Approach to Exploring Novel Therapeutic Space for Colorectal Cancer

  Dar, A., Cagan, R., Dar, A. & Cagan, R. R. L.

  National Cancer Institute

  1/03/21 → 28/02/23

  Project: Research

  • regorafenib 100%
  • Phosphotransferases 62%
  • Colorectal Neoplasms 60%
  • Polypharmacology 20%
  • Aurora Kinase A 17%

• Epigenetic Regulation of the Melanoma Microenvironment

  Bernstein, E.

  U.S. Army

  15/08/20 → 15/08/20

  Project: Research

  • Melanoma 100%
  • Epigenomics 56%
  • Neoplasms 34%
  • Immune System 32%
  • Chromatin 22%

• Research Grant

  Dominguez-Sola, D.

  St. Baldrick's Foundation

  1/07/20 → 30/06/21

  Project: Research

  • Neoplasms 100%
  • Burkitt Lymphoma 93%
  • Cancer Survivors 84%
  • Lymphoma 64%
  • Poisons 57%

• Therapeutic targeting of RNA splicing catalysis through inhibition of Protein Arginine Methylation

  Guccione, E.

  National Cancer Institute

  15/05/20 → 30/04/22

  Project: Research

  • RNA Splicing Factors 100%
  • Protein-Arginine N-Methyltransferases 82%
  • RNA Splicing 76%
  • Catalysis 68%
  • Methylation 61%

• Regulation of Ras in development by post-translational modification

  Pfleger, C. C. M. & Pfleger, C.

  National Institute of General Medical Sciences

  13/03/20 → 28/02/23

  Project: Research

  • Ubiquitination 100%
  • Post Translational Protein Processing 75%
  • Drosophila 57%
  • Tyrosine 56%
  • Phosphorylation 26%

• Function and Regulation of the BCL-2 Family

  Chipuk, J. J. E. & Chipuk, J.

  National Cancer Institute

  1/03/20 → 31/01/23

  Project: Research

  • B-Cell Lymphoma 100%
  • Apoptosis 55%
  • Neoplasms 46%
  • Mitochondrial Membranes 40%
  • Proteins 35%

• A Drosophila model for Alcoholic Liver Disease

  Pfleger, C.

  National Institute on Alcohol Abuse and Alcoholism

  1/07/19 → 30/06/21

  Project: Research

  • Alcoholic Liver Diseases 100%
  • Drosophila 67%
  • Fat Body 24%
  • Alcohols 22%
  • Alcohol Drinking 16%

• Cyclin-dependent kinase control of cell-division and transcription cycles

  Fisher, R.

  National Institute of General Medical Sciences

  1/04/18 → 31/03/22

  Project: Research

  • Cyclin-Dependent Kinases 100%
  • Cell Cycle 59%
  • Cell Cycle Checkpoints 27%
  • cyclin-dependent kinase-activating kinase 25%
  • factor EF-P 12%

• Targeting Oncogenic Ras-MAPK Signaling Complexes via the Scaffold KSR

  Dar, A. & Dar, A.

  National Cancer Institute

  15/03/18 → 28/02/23

  Project: Research

  • Mitogen-Activated Protein Kinases 100%
  • Phosphotransferases 76%
  • Neoplasms 24%
  • Protein Kinase Inhibitors 18%
  • Therapeutic Index 13%

• Identification of therapeutic targets for leukemia stem cells in AML-iPSC models

  Papapetrou, E., Kharas, M., Kharas, M. M. & Papapetrou, E.

  National Cancer Institute

  1/03/18 → 28/02/23

  Project: Research

  • Leukemia 100%
  • Induced Pluripotent Stem Cells 93%
  • Stem Cells 88%
  • Acute Myeloid Leukemia 78%
  • Myeloid Leukemia 50%

• Refined genetic models of oncogenic Myc/Igh translocations in mature B cells

  Dominguez-Sola, D.

  National Cancer Institute

  1/03/18 → 28/02/21

  Project: Research

  • Genetic Models 100%
  • B-Lymphocytes 90%
  • B-Cell Lymphoma 64%
  • Burkitt Lymphoma 49%
  • Germinal Center 48%

• Role of FOXO1 mutations in the pathogenesis of B cell non-Hodgkin lymphomas

  Dominguez-Sola, D.

  National Cancer Institute

  5/02/18 → 31/01/23

  Project: Research

  • Germinal Center 100%
  • B-Cell Lymphoma 87%
  • Non-Hodgkin's Lymphoma 79%
  • Mutation 50%
  • B-Lymphocytes 44%

• Targeting BAP1-dependent alterations in metastatic uveal melanoma

  Aplin, A. E. A. E., Orloff, M. M., Harbour, J. W. J. W. & Bernstein, E.

  Melanoma Research Alliance

  1/01/18 → 31/12/21

  Project: Research

  • Uveal melanoma 100%
  • Melanoma 13%
  • Eye 13%
  • Neoplasm Metastasis 13%
  • Mutation 12%

• 2018 Lymphatics Gordon Research Conference & Gordon Research Seminar

  Skobe, M.

  National Heart, Lung, and Blood Institute

  1/01/18 → 31/12/18

  Project: Research

  • Lymphatic System 100%
  • Lymphatic Vessels 62%
  • Research Personnel 54%
  • Congresses 51%
  • Blood Vessels 45%

• Prognostic and Functional Role of Altered Circular RNAs in Melanoma

  Hernando, E. M. E. M. & Guccione, E.

  Melanoma Research Alliance

  1/01/18 → 31/12/21

  Project: Research

  • Circular RNAs 100%
  • Melanoma 64%
  • RNA 19%
  • Neoplasm Metastasis 16%
  • Neoplasms 11%

• Processing of lesions into DNA repair and checkpoint pathways

  O'Connell, M.

  National Institute of General Medical Sciences

  1/09/17 → 31/08/18

  Project: Research

  • DNA Repair 100%
  • Double-Stranded DNA Breaks 91%
  • Minor Planets 89%
  • Schizosaccharomyces 81%
  • Enzymes 68%

• Research Grant

  Bernstein, E.

  St. Baldrick's Foundation

  1/07/17 → 30/06/18

  Project: Research

  • Neuroblastoma 100%
  • X-linked Nuclear Protein 31%
  • Neurons 30%
  • Chromatin 29%
  • Neoplasms 21%

• Epigenetic and microenvironmental regulation of dormant disseminated cancer

  Aguirre-ghiso, J. J. A., Aguirre-ghiso, J. A. & Bernstein, E.

  National Cancer Institute

  7/06/17 → 31/05/22

  Project: Research

  • epigenetics 100%
  • dormancy 99%
  • neoplasm cells 92%
  • neoplasms 77%
  • metastasis 75%

• Dissecting splicing factor mutations in iPSCs

  Papapetrou, E. & Yeo, E. W.

  National Heart, Lung, and Blood Institute

  5/04/17 → 31/01/21

  Project: Research

  • RNA Splicing Factors 100%
  • Myelodysplastic Syndromes 86%
  • Serine-Arginine Splicing Factors 59%
  • Mutation 43%
  • Induced Pluripotent Stem Cells 28%

• Discover Small Molecule Chemical Probes to Modulate RING-type E3 Ubiquitin Ligases

  Pan, Z.

  National Institute of General Medical Sciences

  1/04/17 → 31/03/21

  Project: Research

  • Probe 100%
  • Molecule 72%
  • Fluorescence Resonance Energy Transfer 66%
  • Robotics 41%
  • High Throughput Screening 36%

• Rabex-5 regulation of Ras and Notch signaling in development and disease

  Pfleger, C.

  National Institute of General Medical Sciences

  1/04/17 → 31/01/21

  Project: Research

  • Drosophila 100%
  • Ubiquitination 93%
  • Ubiquitin 64%
  • Neoplasms 41%
  • Cell Survival 32%

• Modeling Mdm2- and 12q amplicon-driven sarcoma

  Manfredi, J.

  National Cancer Institute

  8/03/17 → 28/02/19

  Project: Research

  • sarcoma 100%
  • neoplasms 80%
  • animal models 73%
  • therapeutics 48%
  • carcinogenesis 45%

• Function of lymphatic vessels in rapid progression of inflammatory breast cancer

  Skobe, M.

  Susan G. Komen

  1/01/17 → 31/12/18

  Project: Research

• Mechanism-based strategies to target oncogenic BRAF signaling

  Poulikakos, P.

  National Cancer Institute

  8/12/16 → 30/11/21

  Project: Research

  • Proto-Oncogene Proteins B-raf 100%
  • Melanoma 76%
  • Dimerization 69%
  • Mitogen-Activated Protein Kinase Kinases 66%
  • Neoplasms 59%

• Enhancing Efficacy of the PD-1/PD-L1 Inhibitor-Mediated Anti-Liver Cancer Immunotherapy Through Promoting CD8+ T-Cell Infiltration by Targeting Angiopoietin-1

  Yu, Q.

  U.S. Army

  15/07/16 → 15/07/16

  Project: Research

  • Angiopoietin-1 100%
  • Hepatocellular Carcinoma 57%
  • Liver Neoplasms 51%
  • Immunotherapy 33%
  • T-Lymphocytes 32%

• ENHANCING EFFICACY OF THE PD-1/PD-L1 INHIBITOR-MEDIATED ANTI-LIVER CANCER IMMUNOTHERAPY THROUGH PROMOTING CD8+ T-CELL INFILTRATION BY TARGETING ANGIOPOIETIN-1

  Yu, Q.

  Congressionally Directed Medical Research Programs

  15/07/16 → 14/07/18

  Project: Research

  • Angiopoietin-1 100%
  • Liver Neoplasms 40%
  • T-Lymphocytes 33%
  • Hepatocellular Carcinoma 32%
  • Immunotherapy 32%

• (PQ5) Role of Mitochondrial Division in Cancer Biology

  Chipuk, J.

  National Cancer Institute

  6/04/16 → 31/03/21

  Project: Research

  • Mitochondrial DNA 100%
  • Mitochondrial Dynamics 73%
  • Neoplasms 68%
  • Mutation 64%
  • Mitochondrial Genome 47%

• Context dependency in MYC-driven B-cell lymphomas

  Dominguez-Sola, D.

  Leukemia Research Foundation

  1/01/16 → 31/12/17

  Project: Research

  • B-Cell Lymphoma 100%
  • Lymphoma 96%
  • Burkitt Lymphoma 46%
  • Gene Targeting 45%
  • Lymphoma, Large B-Cell, Diffuse 43%

• Biological consequences of novel PTEN pathway signaling defects in breast cancer

  Parsons, R.

  Susan G. Komen

  1/01/16 → 31/12/17

  Project: Research

• Role of the p53 C-terminal domain in tissue homeostasis, tumor suppression, and oncogenesis

  Manfredi, J. & Prives, C.

  National Cancer Institute

  15/12/15 → 30/11/20

  Project: Research

  • Carcinogenesis 100%
  • Homeostasis 90%
  • Gene Expression 54%
  • Neoplasms 45%
  • DNA 38%

• Developing therapeutics against resistance to the androgen-deprivation therapy

  Yu, Q.

  National Cancer Institute

  10/12/15 → 30/11/21

  Project: Research

  • Androgens 100%
  • Angiopoietin-1 98%
  • Prostatic Neoplasms 55%
  • Therapeutics 17%
  • TIE-2 Receptor 10%

• Cancer Mechanisms (CM) (Project-002)

  Parsons, R.

  National Cancer Institute

  1/08/15 → 31/07/20

  Project: Research

  • Neoplasms 100%
  • Drive 35%
  • Therapeutics 22%
  • Genetic Research 21%
  • Psychological Identification 21%

• Flow Cytometry

  Ochando, J.

  National Cancer Institute

  1/08/15 → 31/07/20

  Project: Research

  • Flow cytometry 100%
  • Cells 14%
  • Containment of Biohazards 12%
  • Satellites 11%
  • Metabolomics 11%

• Tissue-specific tumor suppressor effects of p53

  Manfredi, J.

  National Cancer Institute

  17/07/15 → 30/06/20

  Project: Research

  • p53 Genes 100%
  • Neoplasms 89%
  • Histones 84%
  • Proteins 83%
  • Transcription Factors 68%

• Research Grant

  Bernstein, E.

  St. Baldrick's Foundation

  1/07/15 → 30/06/16

  Project: Research

  • Neuroblastoma 100%
  • Mutation 74%
  • Nerve Tissue 38%
  • Genomics 33%
  • Neoplasms 21%

• Oncogenes reprogram mitochondrial dynamics via drp1 to favor tumorigenesis

  Chipuk, J.

  American Cancer Society

  1/01/15 → 31/12/18

  Project: Research

• Modeling chromosome 7 loss in Myelodysplasia-iPSCs

  Papapetrou, E.

  National Heart, Lung, and Blood Institute

  1/08/14 → 28/02/19

  Project: Research

  • Chromosomes, Human, Pair 7 100%
  • Myelodysplastic Syndromes 99%
  • Bone Marrow Failure Disorders 39%
  • Genetic Engineering 36%
  • Chromosomes 34%

• IDENTIFYING EPIGENETIC MODULATORS OF RESISTANCE TO ERK SIGNALING INHIBITORS

  Bernstein, E.

  Congressionally Directed Medical Research Programs

  1/08/14 → 31/07/16

  Project: Research

  • melanoma 100%
  • epigenetics 61%
  • chromatin 33%
  • therapeutics 24%
  • neoplasms 23%

• Mechanisms of PTEN-Long Function in Cancer

  Parsons, R.

  National Cancer Institute

  1/05/14 → 30/04/18

  Project: Research

  • neoplasms 100%
  • tumor suppressor genes 53%
  • amino acids 42%
  • start codon 41%
  • cells 41%

• Mechanisms of Lymphatic Metastasis in Melanoma

  Skobe, M.

  National Cancer Institute

  7/04/14 → 29/02/20

  Project: Research

  • Lymphatic Metastasis 100%
  • Melanoma 67%
  • Lymph Nodes 61%
  • Neoplasm Metastasis 28%
  • Lymphatic System 17%

• Role of Replication Stress during Myc-dependent Lymphomagenesis

  Dominguez-Sola, D.

  National Cancer Institute

  7/03/14 → 29/02/16

  Project: Research

  • B-Lymphocytes 100%
  • Aptitude 66%
  • DNA Replication 65%
  • Neoplasms 62%
  • Systems Biology 38%

• EXPLOITING ONCOGENE ADDICTION AND SYNTHETIC LETHAL PHENOTYPES TO DEVISE NOVEL THERAPEUTIC STRATEGIES FOR NF2

  Pfleger, C.

  Congressionally Directed Medical Research Programs

  1/03/14 → 28/02/17

  Project: Research

  • Neurofibromatosis 2 100%
  • Oncogene Addiction 76%
  • Neurofibromin 2 56%
  • Neoplasms 27%
  • Phenotype 26%

• Chemical Genetics of Transcriptional Regulation by CDKs in Human Cells

  Fisher, R.

  National Institute of General Medical Sciences

  15/02/14 → 31/12/18

  Project: Research

  • Cyclin-Dependent Kinases 100%
  • Transcription Factor TFIIH 15%
  • Positive Transcriptional Elongation Factor B 15%
  • Torpedo 13%
  • RNA 12%

• Biological consequences of novel PTEN pathway signaling defects in breast cancer

  Parsons, R.

  Susan G. Komen

  1/01/14 → 31/12/15

  Project: Research

  • breast neoplasms 100%
  • mice 47%
  • stem cells 46%
  • estrogen receptors 41%
  • animal models 32%

• Targeting Ras-Dependent Cancers with a Chemical Switch for an Inactive Kinase

  Dar, A.

  National Cancer Institute

  30/09/13 → 30/06/18

  Project: Research

  • KSR-1 protein kinase 100%
  • Phosphotransferases 32%
  • Neoplasms 14%
  • Point Mutation 7%
  • Protein Kinases 6%

• Chemical Genetic Analysis of the Human Cell Cycle

  Fisher, R.

  National Institute of General Medical Sciences

  1/09/13 → 31/08/16

  Project: Research

  • Cyclin-Dependent Kinases 100%
  • cyclin-dependent kinase-activating kinase 76%
  • Cell Cycle 62%
  • S Phase 42%
  • DNA Damage 24%

• The Seventh International Mdm2 Workshop

  Manfredi, J.

  National Cancer Institute

  1/08/13 → 31/07/14

  Project: Research

  • minority 100%
  • cancer 88%
  • participation 77%
  • graduate 62%
  • applicant 45%

• Hippo Pathway regulation of proliferation and organ homeostasis

  Pfleger, C.

  National Science Foundation

  15/06/13 → 31/05/16

  Project: Research

  • students 100%
  • graduate students 98%
  • homeostasis 85%
  • fruit flies 71%
  • genes 57%