Cancer Biology

48659 Citations
108 h-index
554 Article
94 Review article
38 Comment/debate
26 Chapter
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5-Azacytidine- and retinoic-acid-induced reprogramming of DCCs into dormancy suppresses metastasis via restored TGF-β-SMAD4 signaling
Singh, D. K., Carcamo, S., Farias, E. F., Hasson, D., Zheng, W., Sun, D., Huang, X., Cheung, J., Nobre, A. R., Kale, N., Sosa, M. S., Bernstein, E. & Aguirre-Ghiso, J. A., 27 Jun 2023, In: Cell Reports. 42, 6, 112560.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Scopus citations
Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53
Kabir, M., Sun, N., Hu, X., Martin, T. C., Yi, J., Zhong, Y., Xiong, Y., Kaniskan, H. Ü., Gu, W., Parsons, R. & Jin, J., 12 Jul 2023, In: Journal of the American Chemical Society. 145, 27, p. 14932-14944 13 p.
Research output: Contribution to journal › Article › peer-review
AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
Cahuzac, K. M., Lubin, A., Bosch, K., Stokes, N., Shoenfeld, S. M., Zhou, R., Lemon, H., Asara, J. & Parsons, R. E., 30 May 2023, In: Cell Reports. 42, 5, 112536.
Research output: Contribution to journal › Article › peer-review

Open Access
Apoptotic cell death in disease—Current understanding of the NCCD 2023
Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J. M., Adam, D., Agostini, M., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Aqeilan, R. I., Arama, E., Baehrecke, E. H., Balachandran, S., Bano, D., Barlev, N. A., Bartek, J., Bazan, N. G., & 208 othersBecker, C., Bernassola, F., Bertrand, M. J. M., Bianchi, M. E., Blagosklonny, M. V., Blander, J. M., Blandino, G., Blomgren, K., Borner, C., Bortner, C. D., Bove, P., Boya, P., Brenner, C., Broz, P., Brunner, T., Damgaard, R. B., Calin, G. A., Campanella, M., Candi, E., Carbone, M., Carmona-Gutierrez, D., Cecconi, F., Chan, F. K. M., Chen, G. Q., Chen, Q., Chen, Y. H., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Ciliberto, G., Conrad, M., Cubillos-Ruiz, J. R., Czabotar, P. E., D’Angiolella, V., Daugaard, M., Dawson, T. M., Dawson, V. L., De Maria, R., De Strooper, B., Debatin, K. M., Deberardinis, R. J., Degterev, A., Del Sal, G., Deshmukh, M., Di Virgilio, F., Diederich, M., Dixon, S. J., Dynlacht, B. D., El-Deiry, W. S., Elrod, J. W., Engeland, K., Fimia, G. M., Galassi, C., Ganini, C., Garcia-Saez, A. J., Garg, A. D., Garrido, C., Gavathiotis, E., Gerlic, M., Ghosh, S., Green, D. R., Greene, L. A., Gronemeyer, H., Häcker, G., Hajnóczky, G., Hardwick, J. M., Haupt, Y., He, S., Heery, D. M., Hengartner, M. O., Hetz, C., Hildeman, D. A., Ichijo, H., Inoue, S., Jäättelä, M., Janic, A., Joseph, B., Jost, P. J., Kanneganti, T. D., Karin, M., Kashkar, H., Kaufmann, T., Kelly, G. L., Kepp, O., Kimchi, A., Kitsis, R. N., Klionsky, D. J., Kluck, R., Krysko, D. V., Kulms, D., Kumar, S., Lavandero, S., Lavrik, I. N., Lemasters, J. J., Liccardi, G., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Luedde, T., MacFarlane, M., Madeo, F., Malorni, W., Manic, G., Mantovani, R., Marchi, S., Marine, J. C., Martin, S. J., Martinou, J. C., Mastroberardino, P. G., Medema, J. P., Mehlen, P., Meier, P., Melino, G., Melino, S., Miao, E. A., Moll, U. M., Muñoz-Pinedo, C., Murphy, D. J., Niklison-Chirou, M. V., Novelli, F., Núñez, G., Oberst, A., Ofengeim, D., Opferman, J. T., Oren, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J. M., Pentimalli, F., Pereira, D. M., Pervaiz, S., Peter, M. E., Pinton, P., Porta, G., Prehn, J. H. M., Puthalakath, H., Rabinovich, G. A., Rajalingam, K., Ravichandran, K. S., Rehm, M., Ricci, J. E., Rizzuto, R., Robinson, N., Rodrigues, C. M. P., Rotblat, B., Rothlin, C. V., Rubinsztein, D. C., Rudel, T., Rufini, A., Ryan, K. M., Sarosiek, K. A., Sawa, A., Sayan, E., Schroder, K., Scorrano, L., Sesti, F., Shao, F., Shi, Y., Sica, G. S., Silke, J., Simon, H. U., Sistigu, A., Stephanou, A., Stockwell, B. R., Strapazzon, F., Strasser, A., Sun, L., Sun, E., Sun, Q., Szabadkai, G., Tait, S. W. G., Tang, D., Tavernarakis, N., Troy, C. M., Turk, B., Urbano, N., Vandenabeele, P., Vanden Berghe, T., Vander Heiden, M. G., Vanderluit, J. L., Verkhratsky, A., Villunger, A., von Karstedt, S., Voss, A. K., Vousden, K. H., Vucic, D., Vuri, D., Wagner, E. F., Walczak, H., Wallach, D., Wang, R., Wang, Y., Weber, A., Wood, W., Yamazaki, T., Yang, H. T., Zakeri, Z., Zawacka-Pankau, J. E., Zhang, L., Zhang, H., Zhivotovsky, B., Zhou, W., Piacentini, M., Kroemer, G. & Galluzzi, L., May 2023, In: Cell Death and Differentiation. 30, 5, p. 1097-1154 58 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
10 Scopus citations
Author Correction: A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma (Nature Communications, (2022), 13, 1, (6041), 10.1038/s41467-022-33377-8)
Zhou, R. W., Xu, J., Martin, T. C., Zachem, A. L., He, J., Ozturk, S., Demircioglu, D., Bansal, A., Trotta, A. P., Giotti, B., Gryder, B., Shen, Y., Wu, X., Carcamo, S., Bosch, K., Hopkins, B., Tsankov, A., Steinhagen, R., Jones, D. R., Asara, J., & 7 othersChipuk, J. E., Brody, R., Itzkowitz, S., Chio, I. I. C., Hasson, D., Bernstein, E. & Parsons, R. E., Dec 2023, In: Nature Communications. 14, 1, 1923.
Research output: Contribution to journal › Comment/debate

Open Access
Author Correction: Non-transcriptional control of DNA replication by c-Myc (Nature, (2007), 448, 7152, (445-451), 10.1038/nature05953)
Dominguez-Sola, D., Ying, C. Y., Grandori, C., Ruggiero, L., Chen, B., Li, M., Galloway, D. A., Gu, W., Gautier, J. & Dalla-Favera, R., 13 Jul 2023, In: Nature. 619, 7969, p. E39
Research output: Contribution to journal › Comment/debate
B7-H3 drives immunosuppression and Co-targeting with CD47 is a new therapeutic strategy in β-catenin activated melanomas
Hsu, M., Martin, T. C., Vyas, N. S., Desman, G., Mendelson, K., Horst, B., Parsons, R. E. & Celebi, J. T., 2023, (Accepted/In press) In: Pigment Cell and Melanoma Research.
Research output: Contribution to journal › Article › peer-review
Base editors dissect genetic variants in human hematopoietic cells on a large scale
Papapetrou, E. P., Jul 2023, In: Trends in Immunology. 44, 7, p. 490-492 3 p.
Research output: Contribution to journal › Short survey › peer-review
Blockade of IL-6 signaling alleviates atherosclerosis in Tet2-deficient clonal hematopoiesis
Liu, W., Yalcinkaya, M., Maestre, I. F., Olszewska, M., Ampomah, P. B., Heimlich, J. B., Wang, R., Vela, P. S., Xiao, T., Bick, A. G., Levine, R., Papapetrou, E. P., Libby, P., Tabas, I., Wang, N. & Tall, A. R., Jun 2023, In: Nature Cardiovascular Research. 2, 6, p. 572-586 15 p.
Research output: Contribution to journal › Article › peer-review
2 Scopus citations
C. David Allis (1951-2023)
Bernstein, E., Dent, S., Dou, Y., Duncan, E. M., Hake, S. B., Strahl, B. D. & Wysocka, J., 16 Feb 2023, In: Molecular Cell. 83, 4, p. 497-499 3 p.
Research output: Contribution to journal › Article › peer-review
C. David Allis (1951-2023)
Bernstein, E., Dent, S., Dou, Y., Duncan, E. M., Hake, S. B., Strahl, B. D. & Wysocka, J., 16 Feb 2023, In: Cell. 186, 4, p. 663-667 5 p.
Research output: Contribution to journal › Article › peer-review
Correction: Triple MAPK inhibition salvaged a relapsed post-BCMA CAR-T cell therapy multiple myeloma patient with a BRAF V600E subclonal mutation (Journal of Hematology & Oncology, (2022), 15, 1, (109), 10.1186/s13045-022-01330-3)
Elnaggar, M., Agte, S., Restrepo, P., Ram, M., Melnekoff, D., Adamopoulos, C., Stevens, M. M., Kappes, K., Leshchenko, V., Verina, D., Jagannath, S., Poulikakos, P. I., Parekh, S. & Laganà, A., Dec 2023, In: Journal of Hematology and Oncology. 16, 1, 52.
Research output: Contribution to journal › Comment/debate

Open Access

Reports on Melanoma from Icahn School of Medicine at Mount Sinai Provide New Insights (Macroh2a Restricts Inflammatory Gene Expression In Melanoma Cancer-associated Fibroblasts By Coordinating Chromatin Looping)
Dan Filipescu, Miriam Merad, Nikki Vyas, Robert Sebra, Emily Bernstein, Matthew Goldberg, Helene Salmon & Alice O. Kamphorst
19/09/23
1 item of Media coverage
Press/Media
Study Results from Icahn School of Medicine at Mount Sinai in the Area of Liver Cancer Reported (Wntinib Is a Multi-kinase Inhibitor With Specificity Against & Beta;-catenin Mutant Hepatocellular Carcinoma)
Megan Schwarz, Denis Torre, Amaia Lujambio, Samuel Waxman, Josep Llovet, Jian Jin, Ivan Marazzi, Ernesto Guccione, Augusto Villanueva Rodriguez, Arvin Dar, Amaia Lujambio Goizueta & Alexander Scopton
6/09/23
1 item of Media coverage
Press/Media
Reports from Icahn School of Medicine at Mount Sinai Describe Recent Advances in Cancer (5-azacytidine- and Retinoic-acid-induced Reprogramming of Dccs Into Dormancy Suppresses Metastasis Via Restored Tgf-& Beta;-smad4 Signaling)
Maria Soledad Sosa, Julio Aguirre-Ghiso & Emily Bernstein
22/08/23
1 item of Media coverage
Press/Media
Investigators at Icahn School of Medicine at Mount Sinai Detail Findings in Cancer (Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor P53)
Md Kabir, Yue Zhong, Ramon Parsons & Jian Jin
2/08/23
1 item of Media coverage
Press/Media
Data from Icahn School of Medicine at Mount Sinai Broaden Understanding of Cancer (Etiology of super-enhancer reprogramming and activation in cancer)
Ramon Parsons
26/07/23
1 item of Media coverage
Press/Media
Reports Summarize Hematopoietic Stem Cells Study Results from Icahn School of Medicine at Mount Sinai (Ex Vivo Reprogramming of Human Hematopoietic Stem Cells Is Accompanied By Increased Transcripts of Genes Regulating Metabolic Integrity)
Luena Papa, Umut Özbek, Ramon Parsons, Ronald Hoffman & Christoph Schaniel
25/07/23
1 item of Media coverage
Press/Media
Australia Patent: Application for 'Compositions and methods for treating CDK4/6-mediated cancer' Lapses
Poulikos Poulikakos, Jing Liu & Jian Jin
7/07/23
1 item of Media coverage
Press/Media
Icahn School of Medicine at Mount Sinai Researchers Awarded $15.1 Million Grant to Explore Immune Rejection of Transplanted Organs
Jordi Ochando, Abraham (Bram) Teunissen, Dennis Charney & Zahi Fayad
28/06/23 → 29/06/23
4 items of Media coverage
Press/Media
Icahn School of Medicine at Mount Sinai Researchers Awarded $15.1 Million Grant to Explore Immune Rejection of Transplanted Organs
Jordi Ochando, Abraham (Bram) Teunissen, Dennis Charney & Zahi Fayad
28/06/23
2 items of Media coverage
Press/Media
New models enable deeper research into acute myeloid leukemia
Eirini Papapetrou
19/06/23
1 item of Media coverage
Press/Media
New models enable deeper research into acute myeloid leukemia
Eirini Papapetrou
19/06/23
1 item of Media coverage
Press/Media
Local authors: Beaconsfield’s Liz MacRae; Marc ‘Mais Oui’ Denis; and Sheila Kussner
Robert Fisher
2/06/23
1 item of Media coverage
Press/Media

Cancer Biology

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Collaborations and top research areas from the last five years

Dive into details

Emily Bernstein

Anne Bowcock

Jerry Chipuk

Arvin Dar

David Dominguez-Sola

Robert Fisher

Ernesto Guccione

James Manfredi

Jordi Ochando

Matthew O'Connell

Zhen-Qiang Pan

Eirini Papapetrou

5-Azacytidine- and retinoic-acid-induced reprogramming of DCCs into dormancy suppresses metastasis via restored TGF-β-SMAD4 signaling

Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53

AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Author Correction: A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma (Nature Communications, (2022), 13, 1, (6041), 10.1038/s41467-022-33377-8)

Author Correction: Non-transcriptional control of DNA replication by c-Myc (Nature, (2007), 448, 7152, (445-451), 10.1038/nature05953)

B7-H3 drives immunosuppression and Co-targeting with CD47 is a new therapeutic strategy in β-catenin activated melanomas

Base editors dissect genetic variants in human hematopoietic cells on a large scale

Blockade of IL-6 signaling alleviates atherosclerosis in Tet2-deficient clonal hematopoiesis

C. David Allis (1951-2023)

C. David Allis (1951-2023)

Correction: Triple MAPK inhibition salvaged a relapsed post-BCMA CAR-T cell therapy multiple myeloma patient with a BRAF V600E subclonal mutation (Journal of Hematology & Oncology, (2022), 15, 1, (109), 10.1186/s13045-022-01330-3)

Reports on Melanoma from Icahn School of Medicine at Mount Sinai Provide New Insights (Macroh2a Restricts Inflammatory Gene Expression In Melanoma Cancer-associated Fibroblasts By Coordinating Chromatin Looping)

Study Results from Icahn School of Medicine at Mount Sinai in the Area of Liver Cancer Reported (Wntinib Is a Multi-kinase Inhibitor With Specificity Against & Beta;-catenin Mutant Hepatocellular Carcinoma)

Reports from Icahn School of Medicine at Mount Sinai Describe Recent Advances in Cancer (5-azacytidine- and Retinoic-acid-induced Reprogramming of Dccs Into Dormancy Suppresses Metastasis Via Restored Tgf-& Beta;-smad4 Signaling)

Investigators at Icahn School of Medicine at Mount Sinai Detail Findings in Cancer (Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor P53)

Data from Icahn School of Medicine at Mount Sinai Broaden Understanding of Cancer (Etiology of super-enhancer reprogramming and activation in cancer)

Reports Summarize Hematopoietic Stem Cells Study Results from Icahn School of Medicine at Mount Sinai (Ex Vivo Reprogramming of Human Hematopoietic Stem Cells Is Accompanied By Increased Transcripts of Genes Regulating Metabolic Integrity)

Australia Patent: Application for 'Compositions and methods for treating CDK4/6-mediated cancer' Lapses

Icahn School of Medicine at Mount Sinai Researchers Awarded $15.1 Million Grant to Explore Immune Rejection of Transplanted Organs

Icahn School of Medicine at Mount Sinai Researchers Awarded $15.1 Million Grant to Explore Immune Rejection of Transplanted Organs

New models enable deeper research into acute myeloid leukemia

New models enable deeper research into acute myeloid leukemia

Local authors: Beaconsfield’s Liz MacRae; Marc ‘Mais Oui’ Denis; and Sheila Kussner

Cancer Biology

Fingerprint

Collaborations and top research areas from the last five years

Profiles

Research output

Press/Media