Brain-Body Center

Projects

Projects per year 1986 2011 2015 2016 2017 2018 2019 2021 2024

• 50 Active
• 121 Finished

Projects per year

Search results

• Finished

  Proof-of-Concept and Mechanistic Studies to Repurpose Erectile Dysfunction Drugs for Elderly Females

  Yuen, T. T., Kim, S., Zaidi, M., Kim, S., Yuen, T. & Zaidi, M.

  National Institute on Aging

  1/05/21 → 28/02/23

  Project: Research

  • Type 5 Cyclic Nucleotide Phosphodiesterases 100%
  • Proof of Concept Study 75%
  • Erectile Dysfunction 73%
  • Bone and Bones 51%
  • Vardenafil Dihydrochloride 48%

• Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder

  Cathomas, F.

  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

  1/04/21 → 30/04/21

  Project: Research

• Influence of sleep on hematopoietic stem cell diversity and clonality in cardiovascular disease

  McAlpine, C.

  National Heart, Lung, and Blood Institute

  1/05/20 → 30/04/21

  Project: Research

  • Hematopoietic Stem Cells 100%
  • Sleep 71%
  • Cardiovascular Diseases 43%
  • Hematopoiesis 35%
  • Sleep Deprivation 30%

• Regulation of PTSD Via Neuropeptidergic Signaling in the Brain-Vagus-Body Axis.

  Rajbhandari, A.

  Whitehall Foundation

  1/01/20 → 31/12/20

  Project: Research

• Neuroimmune modulation of neuronal function during cocaine conditioning

  Shuman, T. & Kiraly, D.

  National Institute on Drug Abuse

  15/09/19 → 31/08/21

  Project: Research

  • Granulocyte Colony-Stimulating Factor 100%
  • Cocaine 93%
  • Microglia 67%
  • Nucleus Accumbens 43%
  • Granulocyte Colony-Stimulating Factor Receptors 41%

• Suppression of GWVI Toxin-Activated Microglia and Pathologies by DREADD

  Pasinetti, G.

  U.S. Army

  15/08/19 → 15/08/19

  Project: Research

  • Gulf War 100%
  • Microglia 59%
  • Veterans 34%
  • Pathology 23%
  • Immune System 19%

• SUPPRESSION OF GWVI TOXIN-ACTIVATED MICROGLIA AND PATHOLOGIES BY DREADD

  Pasinetti, G.

  Congressionally Directed Medical Research Programs

  15/08/19 → 14/08/21

  Project: Research

  • Gulf War 100%
  • Microglia 78%
  • Veterans 36%
  • Pathology 27%
  • Psychological Stress 17%

• Interactions between peripheral monocytes and the neurovasculature as a pathomechanism of depression - a translational study

  Cathomas, F.

  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

  1/08/19 → 31/01/21

  Project: Research

  • Monocytes 100%
  • Endothelial Cells 89%
  • Major Depressive Disorder 75%
  • Depression 63%
  • Leukocytes 57%

• Characterizing the inflammatory phenotype of human and mouse models of depression

  Chan, K. & Russo, S.

  Institute of Neurosciences, Mental Health and Addiction

  1/06/19 → 31/05/22

  Project: Research

  • Major Depressive Disorder 100%
  • Inflammation 56%
  • Depression 54%
  • Phenotype 33%
  • Brain 26%

• FSH - an Aging Hormone?

  Zaidi, M. M., Rosen, C. C. J., Rosen, C. J. & Zaidi, M.

  National Institute on Aging

  1/02/19 → 31/01/23

  Project: Research

  • Osteoporosis 100%
  • Hormones 93%
  • Obesity 78%
  • Adiposity 62%
  • Adipocytes 50%

• Studying Atherosclerosis Macrophage Dynamics by Combined PET and Fluorine-MRI

  Fayad, Z. & Fayad, Z. A.

  National Heart, Lung, and Blood Institute

  15/01/19 → 31/12/22

  Project: Research

  • Fluorine 100%
  • Atherosclerosis 61%
  • Macrophages 50%
  • Magnetic Resonance Imaging 47%
  • Positron-Emission Tomography 42%

• Development of novel therapeutics for opioid dependence

  Kenny, P. & Kamenecka, T. M.

  National Institute on Drug Abuse

  30/09/18 → 31/08/20

  Project: Research

  • Opioid-Related Disorders 100%
  • Opioid Analgesics 95%
  • Habenula 64%
  • Oxycodone 62%
  • Structure-Activity Relationship 36%

• Neuro-Immune Biotypes of Depression: Towards Pathophysiology-Based Diagnosis and Personalized Treatment

  Murrough, J.

  Dana Foundation

  6/09/18 → 5/09/21

  Project: Research

  • Major Depressive Disorder 100%
  • Blood-Brain Barrier 57%
  • Depression 41%
  • Tegmentum Mesencephali 30%
  • Anhedonia 29%

• Sleep controls hematopoiesis and regulates atherosclerosis: a novel neuro-immune axis

  McAlpine, C. & Swirski, F.

  Institute of Circulatory and Respiratory Health

  1/09/18 → 31/12/20

  Project: Research

  • Neuroimmunomodulation 100%
  • Sleep 99%
  • Hematopoiesis 75%
  • Atherosclerosis 55%
  • Leukocytes 44%

• Sleep controls hematopoiesis and regulates atherosclerosis: a novel neuro-immune axis

  McAlpine, C.

  Institute of Circulatory and Respiratory Health

  1/09/18 → 31/08/20

  Project: Research

  • Neuroimmunomodulation 100%
  • Sleep 99%
  • Hematopoiesis 75%
  • Atherosclerosis 55%
  • Leukocytes 44%

• TRAF6 Nanoimmunotherapy to resolve plaque inflammation

  Fayad, Z. & Mulder, W.

  National Heart, Lung, and Blood Institute

  15/08/18 → 30/06/20

  Project: Research

  • TNF Receptor-Associated Factor 6 100%
  • HDL Lipoproteins 82%
  • Primates 41%
  • Inflammation 39%
  • Apolipoproteins E 35%

• Parallel Multimodal High-throughput screening to identify activators of the orexin receptors

  Kamenecka, T. M., Kenny, P., Scampavia, L. D., Kamenecka, T. T. M., Scampavia, L. L. D. & Kenny, P. P. J.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  5/07/18 → 30/09/22

  Project: Research

  • Orexin Receptors 100%
  • Orexins 84%
  • Orexin Receptor Antagonists 26%
  • suvorexant 14%
  • Pharmaceutical Chemistry 11%

• Plasma Protein-mediated Effects of ApoE4 Expression on Brain in AD

  Castellano, J.

  BrightFocus Foundation

  1/07/18 → 30/06/21

  Project: Research

  • Apolipoprotein E4 100%
  • Alzheimer Disease 91%
  • Blood Proteins 78%
  • Brain 57%
  • Neurons 42%

• Investigating the role of astrocytic vascular endothelial growth factor A (VEGFA) as a mediator of social stress induced blood-brain barrier disruption and depression-like behaviors in mice

  Cathomas, F.

  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

  1/01/18 → 30/06/19

  Project: Research

  • Blood-Brain Barrier 100%
  • Vascular Endothelial Growth Factor A 77%
  • Claudin-5 62%
  • Depression 59%
  • Nitric Oxide Synthase Type III 47%

• INTERLEUKIN-3 IN ALZHEIMER'S DISEASE

  Swirski, F.

  Cure Alzheimer's Fund

  1/01/18 → 31/12/19

  Project: Research

  • Interleukin-3 100%
  • Microglia 64%
  • Alzheimer Disease 49%
  • Symptom Flare Up 24%
  • Amyloid beta-Peptides 23%

• Regulation of hippocampal plasticity and learning and memory by a bloodborne rejuvenation factor

  Castellano, J.

  National Institute on Aging

  30/09/17 → 30/04/20

  Project: Research

  • Rejuvenation 100%
  • Learning 57%
  • Memory 57%
  • Transcription Factor AP-1 36%
  • Cognitive Dysfunction 35%

• Role of lateral habenula orexin receptor signaling in aggressive social behavior

  Russo, S.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  15/09/17 → 30/06/22

  Project: Research

  • Habenula 100%
  • Orexin Receptors 98%
  • Social Behavior 87%
  • Interpersonal Relations 33%
  • Orexins 27%

• MicroRNAs in schizophrenia

  Kenny, P.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  21/07/17 → 30/04/22

  Project: Research

  • Parvalbumins 100%
  • Interneurons 77%
  • MicroRNAs 64%
  • Schizophrenia 54%
  • Mouse Mirn206 microRNA 23%

• EPIGENETIC MECHANISM LINKING DIABETES AND COGNITIVE DYSFUNCTION

  Wang, J.

  U.S. Department of Veterans Affairs

  1/07/17 → 30/06/21

  Project: Research

• BRAIN BIOAVAILABLE NURR1 TRANSACTIVATOR FOR TREATMENT OF SYNUCLEINOPATHIES

  Pasinetti, G.

  U.S. Department of Veterans Affairs

  1/07/17 → 30/06/19

  Project: Research

  • IRX4204 100%
  • Synucleinopathies 38%
  • Trans-Activators 33%
  • Cytoplasmic and Nuclear Receptors 27%
  • Parkinson Disease 22%

• BRAIN BIOAVAILABLE NURR1 TRANSACTIVATOR FOR TREATMENT OF SYNUCLEINOPATHIES

  Pasinetti, G.

  U.S. Department of Veterans Affairs

  1/07/17 → 30/06/19

  Project: Research

  • IRX4204 100%
  • Synucleinopathies 38%
  • Trans-Activators 33%
  • Cytoplasmic and Nuclear Receptors 27%
  • Parkinson Disease 22%

• Brain Bioavailable Nurr1 Transactivator for Treatment of Synucleinopathies

  Pasinetti, G.

  U.S. Department of Veterans Affairs

  1/07/17 → 30/06/19

  Project: Research

  • IRX4204 100%
  • Synucleinopathies 44%
  • Cytoplasmic and Nuclear Receptors 41%
  • Trans-Activators 38%
  • Parkinson Disease 22%

• Epigenetic Mechanism Linking Diabetes and Cognitive Dysfunction

  Wang, J.

  U.S. Department of Veterans Affairs

  1/07/17 → 30/06/22

  Project: Research

  • Cognitive Dysfunction 100%
  • Epigenomics 97%
  • Type 2 Diabetes Mellitus 95%
  • Histone Deacetylases 74%
  • Energy Metabolism 71%

• EPIGENETIC MECHANISM LINKING DIABETES AND COGNITIVE DYSFUNCTION

  Wang, J.

  U.S. Department of Veterans Affairs

  1/07/17 → 30/06/21

  Project: Research

  • Type 2 Diabetes Mellitus 100%
  • Cognitive Dysfunction 88%
  • Epigenomics 79%
  • Histone Deacetylases 77%
  • Energy Metabolism 60%

• EPIGENETIC MECHANISM LINKING DIABETES AND COGNITIVE DYSFUNCTION

  Wang, J.

  U.S. Department of Veterans Affairs

  1/07/17 → 30/06/21

  Project: Research

  • Type 2 Diabetes Mellitus 100%
  • Cognitive Dysfunction 88%
  • Epigenomics 79%
  • Histone Deacetylases 77%
  • Energy Metabolism 60%

• EPIGENETIC MECHANISM LINKING DIABETES AND COGNITIVE DYSFUNCTION

  Wang, J.

  U.S. Department of Veterans Affairs

  1/07/17 → 30/06/21

  Project: Research

  • Type 2 Diabetes Mellitus 100%
  • Cognitive Dysfunction 88%
  • Epigenomics 79%
  • Histone Deacetylases 77%
  • Energy Metabolism 60%

• Ga68-DOTATATE PET imaging of plaque inflammation

  Fayad, Z.

  National Heart, Lung, and Blood Institute

  15/05/17 → 30/04/21

  Project: Research

  • dotatate gallium ga-68 100%
  • Macrophages 40%
  • Inflammation 29%
  • Cardiovascular Diseases 29%
  • Fluorodeoxyglucose F18 25%

• BLR&D Research Career Scientist Award Application

  Pasinetti, G.

  U.S. Department of Veterans Affairs

  1/04/17 → 31/03/22

  Project: Research

  • Caregivers 100%
  • Mindfulness 93%
  • Psychological Resilience 92%
  • Post-Traumatic Stress Disorders 76%
  • Type 2 Diabetes Mellitus 73%

• Thyrotropin Receptor, Thyrotropin and Mechanisms of Bone Loss

  Zaidi, M., Davies, T., Iqbal, J. & Sun, L.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/04/17 → 31/03/21

  Project: Research

  • Thyrotropin Receptors 100%
  • Thyrotropin 81%
  • Bone and Bones 52%
  • Hyperthyroidism 41%
  • Ovariectomy 21%

• Stress and Atherosclerotic Plaque Macrophages - A Systems Biology Approach

  Fayad, Z., Mani, V., Mulder, W. & Swirski, F.

  National Heart, Lung, and Blood Institute

  17/03/17 → 28/02/22

  Project: Research

  • Systems Biology 100%
  • Atherosclerotic Plaques 87%
  • Atherosclerosis 76%
  • Macrophages 68%
  • Cardiovascular Diseases 45%

• Macrophages in homeostasis and cardiovascular disease

  Swirski, F. & Swirski, F. K.

  National Heart, Lung, and Blood Institute

  1/03/17 → 28/02/22

  Project: Research

  • Macrophages 100%
  • Cardiovascular Diseases 89%
  • Homeostasis 88%
  • Interleukin-3 27%
  • Myocardium 19%

• Colony-stimulating Factors in Cardiovascular Disease

  Swirski, F.

  American Heart Association

  1/01/17 → 31/12/21

  Project: Research

  • Colony-Stimulating Factors 100%
  • Cardiovascular Diseases 61%
  • Macrophages 59%
  • Abdominal Aortic Aneurysm 47%
  • Preliminary Data 46%

• NOVEL PROPHYLACTIC AND THERAPEUTIC INTERVENTIONS FOR STRESS-INDUCED DEPRESSION

  Pasinetti, G.

  U.S. Department of Veterans Affairs

  1/10/16 → 30/09/21

  Project: Research

• NOVEL PROPHYLACTIC AND THERAPEUTIC INTERVENTIONS FOR STRESS-INDUCED DEPRESSION

  Pasinetti, G.

  U.S. Department of Veterans Affairs

  1/10/16 → 30/09/20

  Project: Research

  • Polyphenols 100%
  • Depression 69%
  • Nucleus Accumbens 54%
  • Veterans 41%
  • Anxiety 36%

• Novel Prophylactic and Therapeutic Interventions for Stress-Induced Depression

  Pasinetti, G.

  U.S. Department of Veterans Affairs

  1/10/16 → 30/09/21

  Project: Research

  • Polyphenols 100%
  • Depression 67%
  • Nucleus Accumbens 54%
  • Veterans 41%
  • Anxiety 36%

• NOVEL PROPHYLACTIC AND THERAPEUTIC INTERVENTIONS FOR STRESS-INDUCED DEPRESSION

  Pasinetti, G.

  U.S. Department of Veterans Affairs

  1/10/16 → 30/09/20

  Project: Research

  • Polyphenols 100%
  • Depression 69%
  • Nucleus Accumbens 54%
  • Veterans 41%
  • Anxiety 36%

• NOVEL PROPHYLACTIC AND THERAPEUTIC INTERVENTIONS FOR STRESS-INDUCED DEPRESSION

  Pasinetti, G.

  U.S. Department of Veterans Affairs

  1/10/16 → 30/09/20

  Project: Research

  • Polyphenols 100%
  • Depression 69%
  • Nucleus Accumbens 54%
  • Veterans 41%
  • Anxiety 36%

• Psychosocial stress' effects on macrophage dynamics in atherosclerosis

  Swirski, F.

  National Heart, Lung, and Blood Institute

  1/09/16 → 28/02/22

  Project: Research

  • Atherosclerosis 100%
  • Macrophages 95%
  • Myelopoiesis 29%
  • Monocytes 25%
  • Leukocytes 16%

• PET/MRI of the brain-hematopoiesis-atherosclerosis axis in PTSD patients

  Fayad, Z.

  National Heart, Lung, and Blood Institute

  1/09/16 → 28/02/22

  Project: Research

  • Post-Traumatic Stress Disorders 100%
  • Hematopoiesis 97%
  • Atherosclerosis 78%
  • Magnetic Resonance Imaging 62%
  • Inflammation 48%

• Stress and atherosclerotic plaque macrophages - a systems biology approach

  Fayad, Z.

  National Heart, Lung, and Blood Institute

  1/09/16 → 28/02/22

  Project: Research

  • Biostatistics 100%
  • Macrophages 85%
  • Systems Biology 66%
  • Information management 35%

• Regulation of hippocampal plasticity and learning and memory by a bloodborne rejuvenation factor

  Castellano, J.

  National Institute on Aging

  15/08/16 → 31/08/17

  Project: Research

  • Rejuvenation 100%
  • Learning 58%
  • Memory 58%
  • Transcription Factor AP-1 39%
  • Cognitive Dysfunction 39%

• The relationship between glucocorticoid receptor activation and the neuronal hyperexcitability in the basolateral amygdala in the restraint stress-induced long-lasting anxiety and their implications in the impaired contextual fear extinction

  Munhoz, C. D. C. D. & Goosens, K.

  Fundação de Amparo à Pesquisa do Estado de São Paulo

  1/08/16 → 31/10/18

  Project: Research

  • Basolateral Nuclear Complex 100%
  • Psychological Extinction 81%
  • Fear 67%
  • Glucocorticoid Receptors 62%
  • Anxiety 60%

• Nicotinic receptors and alcohol reinforcement

  Kenny, P.

  National Institute on Alcohol Abuse and Alcoholism

  15/07/16 → 31/03/21

  Project: Research

  • Nicotinyl Alcohol 100%
  • Interpeduncular Nucleus 95%
  • Habenula 84%
  • Nicotinic Receptors 63%
  • Psychology Reinforcement 55%

• SHEEP REQUEST FOR OPTOGENETICS EQUIPMENT

  Pasinetti, G.

  U.S. Department of Veterans Affairs

  1/05/16 → 30/09/16

  Project: Research

  • Optogenetics 100%
  • Sheep 37%
  • Nucleus Accumbens 31%
  • Traumatic Brain Injury 28%
  • Sleep Deprivation 25%

• ShEEP Request for Optogenetics Equipment

  Pasinetti, G.

  U.S. Department of Veterans Affairs

  1/05/16 → 30/09/16

  Project: Research

  • Optogenetics 100%
  • Nucleus Accumbens 26%
  • Equipment and Supplies 26%
  • Traumatic Brain Injury 24%
  • Neurons 22%