Alzheimer's Disease Research Center

2025

The thalamus: Structure, function, and neurotherapeutics

Marcuse, L. V., Langan, M., Hof, P. R., Panov, F., Saez, I., Jimenez-Shahed, J., Figee, M., Mayberg, H., Yoo, J. Y., Ghatan, S., Balchandani, P. & Fields, M. C., Mar 2025, In: Neurotherapeutics. 22, 2, e00550.

Research output: Contribution to journal › Review article › peer-review

Open Access

2024

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference

Kloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., Carrillo, M. C., Chen, X., Chiba-Falek, O., Davis, A. A., Paolo, G. D., Garretti, F., Gate, D., Golden, L. R., Heinecke, J. W., Herz, J., Huang, Y., Iadecola, C., Johnson, L. A., Kanekiyo, T., Karch, C. M. & Khvorova, A. & 40 others, Koppes-den Hertog, S. J., Lamb, B. T., Lawler, P. E., Guen, Y. L., Litvinchuk, A., Liu, C. C., Mahinrad, S., Marcora, E., Marino, C., Michaelson, D. M., Miller, J. J., Morganti, J. M., Narayan, P. S., Naslavsky, M. S., Oosthoek, M., Ramachandran, K. V., Ramakrishnan, A., Raulin, A. C., Robert, A., Saleh, R. N. M., Sexton, C., Shah, N., Shue, F., Sible, I. J., Soranno, A., Strickland, M. R., Tcw, J., Thierry, M., Tsai, L. H., Tuckey, R. A., Ulrich, J. D., van der Kant, R., Wang, N., Wellington, C. L., Weninger, S. C., Yassine, H. N., Zhao, N., Bu, G., Goate, A. M. & Holtzman, D. M., Sep 2024, In: Alzheimer's and Dementia. 20, 9, p. 6590-6605 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

7 Scopus citations

Assessing the Impact and Cost-Effectiveness of Exposome Interventions on Alzheimer’s Disease: A Review of Agent-Based Modeling and Other Data Science Methods for Causal Inference

Liu, S. H., Weber, E. S., Manz, K. E., McCarthy, K. J., Chen, Y., Schüffler, P. J., Zhu, C. W. & Tracy, M., Nov 2024, In: Genes. 15, 11, 1457.

Research output: Contribution to journal › Review article › peer-review

Open Access

Basic Science and Pathogenesis

Goate, A. M., Marcora, E. & Cruchaga, C., 1 Dec 2024, In: Alzheimer's and Dementia. 20, p. e093138

Research output: Contribution to journal › Review article › peer-review

Open Access

Betz cells of the primary motor cortex

Nolan, M., Scott, C., Hof, P. R. & Ansorge, O., Jan 2024, In: Journal of Comparative Neurology. 532, 1, p. 1-29 29 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

8 Scopus citations

Donanemab, another anti-Alzheimer's drug with risk and uncertain benefit

Høilund-Carlsen, P. F., Alavi, A., Barrio, J. R., Castellani, R. J., Costa, T., Herrup, K., Kepp, K. P., Neve, R. L., Perry, G., Revheim, M. E., Robakis, N. K., Sensi, S. L. & Vissel, B., Aug 2024, In: Ageing Research Reviews. 99, 102348.

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Neurodegeneration: 2024 update

Crary, J. F., 2024, In: Free Neuropathology. 5, 31.

Research output: Contribution to journal › Review article › peer-review

New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop

Telpoukhovskaia, M. A., Murdy, T. J., Marola, O. J., Charland, K., MacLean, M., Luquez, T., Lish, A. M., Neuner, S., Dunn, A., Onos, K. D., Wiley, J., Archer, D., Huentelman, M. J., Arnold, M., Menon, V., Goate, A., Van Eldik, L. J., Territo, P. R., Howell, G. R. & Carter, G. W. & 2 others, O'Connell, K. M. S. & Kaczorowski, C. C., 1 Jan 2024, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 10, 1, e12458.

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Scopus citations

Novel avenues of tau research

Sexton, C. E., Bitan, G., Bowles, K. R., Brys, M., Buée, L., Maina, M. B., Clelland, C. D., Cohen, A. D., Crary, J. F., Dage, J. L., Diaz, K., Frost, B., Gan, L., Goate, A. M., Golbe, L. I., Hansson, O., Karch, C. M., Kolb, H. C., La Joie, R. & Lee, S. E. & 16 others, Matallana, D., Miller, B. L., Onyike, C. U., Quiroz, Y. T., Rexach, J. E., Rohrer, J. D., Rommel, A., Sadri-Vakili, G., Schindler, S. E., Schneider, J. A., Sperling, R. A., Teunissen, C. E., Weninger, S. C., Worley, S. L., Zheng, H. & Carrillo, M. C., Mar 2024, In: Alzheimer's and Dementia. 20, 3, p. 2240-2261 22 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

6 Scopus citations

Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease

Vance, J. M., Farrer, L. A., Huang, Y., Cruchaga, C., Hyman, B. T., Pericak-Vance, M. A., Goate, A. M., Greicius, M. D., Griswold, A. J., Haines, J. L., Tcw, J., Schellenberg, G. D., Tsai, L. H., Herz, J. & Holtzman, D. M., Apr 2024, In: Annals of Neurology. 95, 4, p. 625-634 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

12 Scopus citations

Revision of Alzheimer's diagnostic criteria or relocation of the Potemkin village

Høilund-Carlsen, P. F., Alavi, A., Barrio, J. R., Castellani, R. J., Costa, T., Herrup, K., Kepp, K. P., Neve, R. L., Perry, G., Revheim, M. E., Robakis, N. K., Sensi, S. L. & Vissel, B., Jan 2024, In: Ageing Research Reviews. 93, 102173.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Scopus citations

The Neurovascular Unit as a Locus of Injury in Low-Level Blast-Induced Neurotrauma

Elder, G. A., Gama Sosa, M. A., De Gasperi, R., Perez Garcia, G., Perez, G. M., Abutarboush, R., Kawoos, U., Zhu, C. W., Janssen, W. G. M., Stone, J. R., Hof, P. R., Cook, D. G. & Ahlers, S. T., Jan 2024, In: International Journal of Molecular Sciences. 25, 2, 1150.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Scopus citations

Unraveling the complex role of MAPT-containing H1 and H2 haplotypes in neurodegenerative diseases

Pedicone, C., Weitzman, S. A., Renton, A. E. & Goate, A. M., Dec 2024, In: Molecular Neurodegeneration. 19, 1, 43.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Scopus citations

2023

5. Collaborative Study on the Genetics of Alcoholism: Functional genomics

Gameiro-Ros, I., Popova, D., Prytkova, I., Pang, Z. P., Liu, Y., Dick, D., Bucholz, K. K., Agrawal, A., Porjesz, B., Goate, A. M., Xuei, X., Kamarajan, C., Tischfield, J. A., Edenberg, H. J., Slesinger, P. A. & Hart, R. P., Oct 2023, In: Genes, Brain and Behavior. 22, 5, e12855.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

APOE and immunity: Research highlights

Kloske, C. M., Barnum, C. J., Batista, A. F., Bradshaw, E. M., Brickman, A. M., Bu, G., Dennison, J., Gearon, M. D., Goate, A. M., Haass, C., Heneka, M. T., Hu, W. T., Huggins, L. K. L., Jones, N. S., Koldamova, R., Lemere, C. A., Liddelow, S. A., Marcora, E., Marsh, S. E. & Nielsen, H. M. & 20 others, Petersen, K. K., Petersen, M., Piña-Escudero, S. D., Qiu, W. Q., Quiroz, Y. T., Reiman, E., Sexton, C., Tansey, M. G., Tcw, J., Teunissen, C. E., Tijms, B. M., van der Kant, R., Wallings, R., Weninger, S. C., Wharton, W., Wilcock, D. M., Wishard, T. J., Worley, S. L., Zetterberg, H. & Carrillo, M. C., Jun 2023, In: Alzheimer's and Dementia. 19, 6, p. 2677-2696 20 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

10 Scopus citations

Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts

McKee, A. C., Stein, T. D., Huber, B. R., Crary, J. F., Bieniek, K., Dickson, D., Alvarez, V. E., Cherry, J. D., Farrell, K., Butler, M., Uretsky, M., Abdolmohammadi, B., Alosco, M. L., Tripodis, Y., Mez, J. & Daneshvar, D. H., Apr 2023, In: Acta Neuropathologica. 145, 4, p. 371-394 24 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

99 Scopus citations

Metals in Alzheimer’s Disease

Babić Leko, M., Langer Horvat, L., Španić Popovački, E., Zubčić, K., Hof, P. R. & Šimić, G., Apr 2023, In: Biomedicines. 11, 4, 1161.

Research output: Contribution to journal › Review article › peer-review

Open Access

28 Scopus citations

Neurodegeneration: 2023 update

Crary, J. F., 2023, In: Free Neuropathology. 4, 13.

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Neuropathologic findings in a young woman 4 years following declaration of brain death: case analysis and literature review

Folkerth, R. D., Crary, J. F. & Shewmon, D. A., 1 Jan 2023, In: Journal of Neuropathology and Experimental Neurology. 82, 1, p. 6-20 15 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Scopus citations

Passive Alzheimer's immunotherapy: A promising or uncertain option?

Høilund-Carlsen, P. F., Revheim, M. E., Costa, T., Alavi, A., Kepp, K. P., Sensi, S. L., Perry, G., Robakis, N. K., Barrio, J. R. & Vissel, B., Sep 2023, In: Ageing Research Reviews. 90, 101996.

Research output: Contribution to journal › Review article › peer-review

Open Access

25 Scopus citations

Postmortem changes in brain cell structure: a review

Krassner, M. M., Kauffman, J., Sowa, A., Cialowicz, K., Walsh, S., Farrell, K., Crary, J. F. & McKenzie, A. T., 2023, In: Free Neuropathology. 4, 10.

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

The amyloid cascade hypothesis: an updated critical review

Kepp, K. P., Robakis, N. K., Høilund-Carlsen, P. F., Sensi, S. L. & Vissel, B., 1 Oct 2023, In: Brain. 146, 10, p. 3969-3990 22 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

87 Scopus citations

The Anti-Amyloid Monoclonal Antibody Lecanemab: 16 Cautionary Notes

Kepp, K. P., Sensi, S. L., Johnsen, K. B., Barrio, J. R., Høilund-Carlsen, P. F., Neve, R. L., Alavi, A., Herrup, K., Perry, G., Robakis, N. K., Vissel, B. & Espay, A. J., 2023, In: Journal of Alzheimer's Disease. 94, 2, p. 497-507 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

26 Scopus citations

The collaborative study on the genetics of alcoholism: Sample and clinical data

COGA Collaborators, Oct 2023, In: Genes, Brain and Behavior. 22, 5, e12860.

Research output: Contribution to journal › Review article › peer-review

Open Access

8 Scopus citations

The collaborative study on the genetics of alcoholism: Genetics

Johnson, E. C., Salvatore, J. E., Lai, D., Merikangas, A. K., Nurnberger, J. I., Tischfield, J. A., Xuei, X., Kamarajan, C., Wetherill, L., Rice, J. P., Kramer, J. R., Kuperman, S., Foroud, T., Slesinger, P. A., Goate, A. M., Porjesz, B., Dick, D. M., Edenberg, H. J. & Agrawal, A., Oct 2023, In: Genes, Brain and Behavior. 22, 5, e12856.

Research output: Contribution to journal › Review article › peer-review

Open Access

13 Scopus citations

The Collaborative Study on the Genetics of Alcoholism: Overview

COGA Collaborators, Oct 2023, In: Genes, Brain and Behavior. 22, 5, e12864.

Research output: Contribution to journal › Review article › peer-review

Open Access

7 Scopus citations

The complex genetic architecture of Alzheimer's disease: novel insights and future directions

Andrews, S. J., Renton, A. E., Fulton-Howard, B., Podlesny-Drabiniok, A., Marcora, E. & Goate, A. M., Apr 2023, In: eBioMedicine. 90, 104511.

Research output: Contribution to journal › Review article › peer-review

Open Access

131 Scopus citations

2022

Alzheimer's disease research progress in the Mediterranean region: The Alzheimer's Association International Conference Satellite Symposium

Sexton, C., Solis, M., Aharon-Peretz, J., Alexopoulos, P., Apostolova, L. G., Bayen, E., Birkenhager, B., Cappa, S., Constantinidou, F., Fortea, J., Gerritsen, D. L., Hassanin, H. I., Ibanez, A., Ioannidis, P., Karageorgiou, E., Korczyn, A., Leroi, I., Lichtwarck, B., Logroscino, G. & Lynch, C. & 17 others, Mecocci, P., Molinuevo, J. L., Papatriantafyllou, J., Papegeorgiou, S., Politis, A., Raman, R., Ritchie, K., Sanchez-Juan, P., Sano, M., Scarmeas, N., Spiru, L., Stathi, A., Tsolaki, M., Yener, G., Zaganas, I., Zygouris, S. & Carrillo, M., Oct 2022, In: Alzheimer's and Dementia. 18, 10, p. 1957-1968 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Scopus citations

ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias

Martens, Y. A., Zhao, N., Liu, C. C., Kanekiyo, T., Yang, A. J., Goate, A. M., Holtzman, D. M. & Bu, G., 20 Apr 2022, In: Neuron. 110, 8, p. 1304-1317 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

159 Scopus citations

Cognitive impairment and World Trade Centre-related exposures

Clouston, S. A. P., Hall, C. B., Kritikos, M., Bennett, D. A., DeKosky, S., Edwards, J., Finch, C., Kreisl, W. C., Mielke, M., Peskind, E. R., Raskind, M., Richards, M., Sloan, R. P., Spiro, A., Vasdev, N., Brackbill, R., Farfel, M., Horton, M., Lowe, S. & Lucchini, R. G. & 12 others, Prezant, D., Reibman, J., Rosen, R., Seil, K., Zeig-Owens, R., Deri, Y., Diminich, E. D., Fausto, B. A., Gandy, S., Sano, M., Bromet, E. J. & Luft, B. J., Feb 2022, In: Nature Reviews Neurology. 18, 2, p. 103-116 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

27 Scopus citations

Connecting Cohorts to Diminish Alzheimer's Disease (CONCORD-AD): A Report of an International Research Collaboration Network

Pavlik, V. N., Burnham, S. C., Kass, J. S., Helmer, C., Palmqvist, S., Vassilaki, M., Dartigues, J. F., Hansson, O., Masters, C. L., Pérès, K., Petersen, R. C., Stomrud, E., Butler, L., Coloma, P. M., Teitsma, X. M., Doody, R. & Sano, M., 2022, In: Journal of Alzheimer's Disease. 85, 1, p. 31-45 15 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

Current directions in tau research: Highlights from Tau 2020

Sexton, C., Snyder, H., Beher, D., Boxer, A. L., Brannelly, P., Brion, J. P., Buée, L., Cacace, A. M., Chételat, G., Citron, M., DeVos, S. L., Diaz, K., Feldman, H. H., Frost, B., Goate, A. M., Gold, M., Hyman, B., Johnson, K., Karch, C. M. & Kerwin, D. R. & 15 others, Koroshetz, W. J., Litvan, I., Morris, H. R., Mummery, C. J., Mutamba, J., Patterson, M. C., Quiroz, Y. T., Rabinovici, G. D., Rommel, A., Shulman, M. B., Toledo-Sherman, L. M., Weninger, S., Wildsmith, K. R., Worley, S. L. & Carrillo, M. C., May 2022, In: Alzheimer's and Dementia. 18, 5, p. 988-1007 20 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

48 Scopus citations

Emergency Department Care Transitions for Patients With Cognitive Impairment: A Scoping Review

The GEAR 2.0-ADC Network, Aug 2022, In: Journal of the American Medical Directors Association. 23, 8, p. 1313.e1-1313.e13

Research output: Contribution to journal › Review article › peer-review

Open Access

29 Scopus citations

Emergency Department Communication in Persons Living With Dementia and Care Partners: A Scoping Review

Geriatric Emergency care Applied Research 2.0 Network, Aug 2022, In: Journal of the American Medical Directors Association. 23, 8, p. 1313.e15-1313.e46

Research output: Contribution to journal › Review article › peer-review

Open Access

27 Scopus citations

Hope or hype? Aducanumab as a magic bullet for Alzheimer's disease

Lin, W. J., Xiao, C. & Salton, S. R., 2022, In: BIO Integration. 3, 2, p. 84-88 5 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

Infection and inflammation: New perspectives on Alzheimer's disease

Symposium Planning Committee members, Jul 2022, In: Brain, Behavior, and Immunity - Health. 22, 100462.

Research output: Contribution to journal › Review article › peer-review

Open Access

21 Scopus citations

Intranasal Peptide Therapeutics: A Promising Avenue for Overcoming the Challenges of Traditional CNS Drug Development

Bose, M., Farias Quipildor, G., Ehrlich, M. E. & Salton, S. R., Nov 2022, In: Cells. 11, 22, 3629.

Research output: Contribution to journal › Review article › peer-review

Open Access

20 Scopus citations

Microglial efferocytosis: Diving into the Alzheimer's disease gene pool

Romero-Molina, C., Garretti, F., Andrews, S. J., Marcora, E. & Goate, A. M., 2 Nov 2022, In: Neuron. 110, 21, p. 3513-3533 21 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

43 Scopus citations

Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2

Haure-Mirande, J. V., Audrain, M., Ehrlich, M. E. & Gandy, S., Dec 2022, In: Molecular Neurodegeneration. 17, 1, 55.

Research output: Contribution to journal › Review article › peer-review

Open Access

70 Scopus citations

Multi-omic insights into Parkinson's Disease: From genetic associations to functional mechanisms

Schilder, B. M., Navarro, E. & Raj, T., Feb 2022, In: Neurobiology of Disease. 163, 105580.

Research output: Contribution to journal › Review article › peer-review

Open Access

25 Scopus citations

Neurodegeneration: 2022 update

Crary, J. F., 2022, In: Free Neuropathology. 3, 13.

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Neurotrophin Crosstalk in the Etiology and Treatment of Neuropsychiatric and Neurodegenerative Disease

Joshi, R. & Salton, S. R. J., 15 Jul 2022, In: Frontiers in Molecular Neuroscience. 15, 932497.

Research output: Contribution to journal › Review article › peer-review

Open Access

16 Scopus citations

New developments of biofluid-based biomarkers for routine diagnosis and disease trajectories in frontotemporal dementia

del Campo, M., Zetterberg, H., Gandy, S., Onyike, C. U., Oliveira, F., Udeh-Momoh, C., Lleó, A., Teunissen, C. E. & Pijnenburg, Y., Nov 2022, In: Alzheimer's and Dementia. 18, 11, p. 2292-2307 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

24 Scopus citations

The influence of 17q21.31 and APOE genetic ancestry on neurodegenerative disease risk

Harerimana, N. V., Goate, A. M. & Bowles, K. R., 20 Oct 2022, In: Frontiers in Aging Neuroscience. 14, 1021918.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

2021

Comparative neuropathology in aging primates: A perspective

Freire-Cobo, C., Edler, M. K., Varghese, M., Munger, E., Laffey, J., Raia, S., In, S. S., Wicinski, B., Medalla, M., Perez, S. E., Mufson, E. J., Erwin, J. M., Guevara, E. E., Sherwood, C. C., Luebke, J. I., Lacreuse, A., Raghanti, M. A. & Hof, P. R., Nov 2021, In: American Journal of Primatology. 83, 11, e23299.

Research output: Contribution to journal › Review article › peer-review

Open Access

23 Scopus citations

Demographic, Health, and Exposure Risks Associated With Cognitive Loss, Alzheimer's Disease and Other Dementias in US Military Veterans

Zhu, C. W. & Sano, M., 25 Feb 2021, In: Frontiers in Psychiatry. 12, 610334.

Research output: Contribution to journal › Review article › peer-review

Open Access

22 Scopus citations

Modifiable Risk Factors in Alzheimer Disease and Related Dementias: A Review

Litke, R., Garcharna, L. C., Jiwani, S. & Neugroschl, J., Jun 2021, In: Clinical Therapeutics. 43, 6, p. 953-965 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

50 Scopus citations

Molecules, mechanisms, and disorders of self-domestication: Keys for understanding emotional and social communication from an evolutionary perspective

Šimić, G., Vukić, V., Kopić, J., Krsnik, Ž. & Hof, P. R., Jan 2021, In: Biomolecules. 11, 1, p. 1-39 39 p., 2.

Research output: Contribution to journal › Review article › peer-review

Open Access

16 Scopus citations

The molecular identity of the TLQP-21 peptide receptor

Sahu, B. S., Nguyen, M. E., Rodriguez, P., Pallais, J. P., Ghosh, V., Razzoli, M., Sham, Y. Y., Salton, S. R. & Bartolomucci, A., Dec 2021, In: Cellular and Molecular Life Sciences. 78, 23, p. 7133-7144 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Scopus citations

Unconventional animal models for traumatic brain injury and chronic traumatic encephalopathy

Ackermans, N. L., Varghese, M., Wicinski, B., Torres, J., De Gasperi, R., Pryor, D., Elder, G. A., Gama Sosa, M. A., Reidenberg, J. S., Williams, T. M. & Hof, P. R., Oct 2021, In: Journal of Neuroscience Research. 99, 10, p. 2463-2477 15 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

21 Scopus citations

Alzheimer's Disease Research Center

Research output

Search results