Alper Center for Neural Development and Regeneration

Icahn School of Medicine at Mount Sinai

2465 Citations
24 h-index
120 Article
14 Review article
9 Comment/debate
1 Chapter
More

3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene Signatures
Lee, V. K., Tejero, R., Silvia, N., Sattiraju, A., Ramakrishnan, A., Shen, L., Wojcinski, A., Kesari, S., Friedel, R. H., Zou, H. & Dai, G., 2025, (Accepted/In press) In: Advanced Science.
Research output: Contribution to journal › Article › peer-review
APOE genotype and brain amyloid are associated with changes in the plasma proteome in elderly subjects without dementia
Philippi, S. M., Kailash, B. P., Raj, T. & Castellano, J. M., Feb 2025, In: Annals of Clinical and Translational Neurology. 12, 2, p. 366-382 17 p.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Scopus citations
A rapid and robust protocol for generating loss-of-function alleles in pluripotent stem cells
Baljinnyam, E., Grisanti, L., Tattari, S., Pedicone, C., Shewale, B., Dubois, N., Goate, A. M., Kerr, W. G. & Marro, S. G., 19 Sep 2025, In: STAR Protocols. 6, 3, 103916.
Research output: Contribution to journal › Article › peer-review
Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia (Nature Genetics, (2024), 56, 11, (2407-2421), 10.1038/s41588-024-01939-9)
The National Alzheimer’s Coordinating Center & The Alzheimer’s Disease Genetics Consortium, 2025, (Accepted/In press) In: Nature Genetics.
Research output: Contribution to journal › Comment/debate
CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer’s disease risk
Nguyen, L., Ajredini, R., Guo, S., Romano, L. E. L., Tomas, R. F., Bell, L. R., Ranum, P. T., Zu, T., Coronel, M. B., Kelley, C. P., Redding-Ochoa, J., Nizamis, E., Melloni, A., Connors, T. R., Gaona, A., Thangaraju, K., Pletnikova, O., Brent Clark, H., Davidson, B. L. & Yachnis, A. T. & 10 others, Golde, T. E., Lou, X. Y., Wang, E. T., Renton, A. E., Goate, A., Valdmanis, P. N., Prokop, S., Troncoso, J. C., Hyman, B. T. & Ranum, L. P. W., 19 Feb 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 7, e2416885122.
Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Clinical, Genomic, and Neurophysiological Correlates of Lifetime Suicide Attempts among Individuals with an Alcohol Use Disorder
Barr, P. B., Neale, Z., Chatzinakos, C., Schulman, J., Mullins, N., Zhang, J., Chorlian, D. B., Kamarajan, C., Kinreich, S., Pandey, A. K., Pandey, G., Saenz De Viteri, S., Acion, L., Bauer, L., Bucholz, K. K., Chan, G., Dick, D. M., Edenberg, H. J., Foroud, T. & Goate, A. & 10 others, Hesselbrock, V., Johnson, E. C., Kramer, J. R., Lai, D., Plawecki, M. H., Salvatore, J., Wetherill, L., Agrawal, A., Porjesz, B. & Meyers, J. L., 13 Feb 2025, In: Complex Psychiatry. 11, 1
Research output: Contribution to journal › Article › peer-review
3 Scopus citations
Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells
PSP Genetics Study Group, May 2025, In: Movement Disorders. 40, 5, p. 950-961 12 p.
Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Correction to: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction (Nature Neuroscience, (2021), 24, 10, (1367-1376), 10.1038/s41593-021-00908-3)
COGA Collaborators, Jan 2025, In: Nature Neuroscience. 28, 1, p. 213 1 p.
Research output: Contribution to journal › Comment/debate

Open Access
2 Scopus citations
Cytokine-induced reprogramming of human macrophages toward Alzheimer's disease-relevant molecular and cellular phenotypes in vitro
Podleśny-Drabiniok, A., Romero-Molina, C., Patel, T., See, W. Y., Liu, Y., Marcora, E. & Goate, A. M., 22 Jul 2025, In: Cell Reports. 44, 7, 115909.
Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Emerging connections between myelin and Alzheimer’s disease
Bright, A., Akay, L. A., Blanchard, J. & Tsai, L. H., Jul 2025, In: Nature Cell Biology. 27, 7, p. 1049-1051 3 p.
Research output: Contribution to journal › Comment/debate
1 Scopus citations
Frequency of variants in Mendelian Alzheimer's disease genes within the Alzheimer's Disease Sequencing Project
Alzheimer's Disease Neuroimaging Initiative (ADNI), The Alzheimer's Disease Sequencing Project, Apr 2025, In: Journal of Alzheimer's Disease. 104, 3, p. 841-851 11 p.
Research output: Contribution to journal › Article › peer-review
Generation of induced pluripotent stem cell line ISMMSi060-A from a patient with combined oxidative phosphorylation deficiency 25
Salemi, S. E., Baljinnyam, E., Liu, N. N., Hu, R., Marro, S. G. & Webb, B. D., Mar 2025, In: Stem Cell Research. 83, 103662.
Research output: Contribution to journal › Article › peer-review

Open Access

U.S. Patents Awarded to Inventors in Massachusetts (May 10)
Blanchard, J. & Victor, M. B.
10/05/25
1 item of Media coverage
Press/Media
APOE4 Impairs Myelination via Altered Cholesterol Biosynthesis and Transport in Oligodendroglia
Blanchard, J. & Victor, M. B.
29/04/25
1 item of Media coverage
Press/Media
New Genetic Risk Study Findings Have Been Reported by Investigators at Icahn School of Medicine at Mount Sinai (Long-read Rna Sequencing Atlas of Human Microglia Isoforms Elucidates Disease-associated Genetic Regulation of Splicing)
Zeng, B., Sebra, R., Raj, T., Haroutunian, V., Roussos, P., Fullard, J., De Witte, L., Hoffman, G. & Goate, A.
9/04/25
1 item of Media coverage
Press/Media
Investigators at University of Pennsylvania Discuss Findings in Progressive Supranuclear Palsy (Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated With Progressive Supranuclear Palsy and Gene Expression ...)
Goate, A.
4/04/25
1 item of Media coverage
Press/Media
《第一欄》TO THE AMERICAN PEOPLE
Goodenough, U., Buxbaum, J., Bhardwaj, N., Desnick, R., Goate, A., Chen, H., Cohen,, E., Cohen, J., Cohen, J., Goldman, M., Appel, J., Fowler, J., Green, R. & Diamond, S.
2/04/25
1 item of Media coverage
Press/Media
Research on Lewy Body Disease Detailed by a Researcher at University College London (UCL) (Investigation of the genetic aetiology of Lewy body diseases with and without dementia)
Goate, A. & Renton, A. E.
1/04/25
1 item of Media coverage
Press/Media
Anti-Amyloid Drug Shows Promise in Preventing Alzheimer’s
Renton, A. E. & Goate, A.
20/03/25
1 item of Media coverage
Press/Media
Findings in Chromatin Reported from Icahn School of Medicine at Mount Sinai (Single Chromatin Fiber Profiling and Nucleosome Position Mapping In the Human Brain)
Dawson, T., Sebra, R., Akbarian, S., Roussos, P., Tsankova, N. & Girdhar, K.
26/02/25
1 item of Media coverage
Press/Media
Studies in the Area of Alzheimer Disease Reported from Washington University (Evaluating brain age using functional connectivity in autosomal dominant Alzheimer disease)
Goate, A.
11/02/25
1 item of Media coverage
Press/Media
University of California Researcher Provides New Data on Health and Medicine (Human iPSC derived organoid models to study tau pathology)
Goate, A.
6/02/25
1 item of Media coverage
Press/Media
New Findings from Icahn School of Medicine at Mount Sinai in the Area of Alzheimer Disease Described (Identification of genetically driven Therapeutic Targets for Alzheimer's disease)
Marcora, E. & Goate, A.
28/01/25
1 item of Media coverage
Press/Media
Reports on Alzheimer Disease Findings from Icahn School of Medicine at Mount Sinai Provide New Insights (Spatial Proteomic Differences In Chronic Traumatic Encephalopathy, Alzheimer's Disease, and Primary Age-related Tauopathy Hippocampi)
Farrell, K., Goate, A., Stein, D., White, L., Crary, J. & Stein, D.
27/01/25
1 item of Media coverage
Press/Media