Alper Center for Neural Development and Regeneration

Icahn School of Medicine at Mount Sinai

3326 Citations
30 h-index
163 Article
16 Comment/debate
14 Review article
2 Letter
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AhR inhibition promotes axon regeneration via a stress–growth switch
Halawani, D., Wang, Y., Li, J., Halperin, D., Ni, H., Estill, M., Ramakrishnan, A., Shen, L., Sefiani, A., Geoffroy, C. G., Friedel, R. H. & Zou, H., 2026, (Accepted/In press) In: Nature.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Scopus citations
A meta-analysis of single-nucleus expression quantitative trait loci linking genetic risk to brain disorders
Jang, B., BP, K., Tokolyi, A., Dredge, W. H., Ravi, A., Jung, S. H., Naito, T., Kim, B., Kim, M. S., Cho, M., Park, M. S., Rosen, M., Blanchard, J., Humphrey, J., Knowles, D. A., Won, H. H. & Raj, T., Apr 2026, In: Nature Genetics. 58, 4, p. 737-747 11 p.
Research output: Contribution to journal › Article › peer-review
Author Correction: A streamlined base editor engineering strategy to reduce bystander editing (Nature Communications, (2025), 16, 1, (8115), 10.1038/s41467-025-63609-6)
Valdez, I., O’Connor, I., Patel, D., Gierer, K., Harrington, J., Ellis, E., Caponetti, S. A., Sebra, R. P., Valley, H. C., Coote, K., Mense, M., Marro, S. G. & Jiang, T., Dec 2026, In: Nature Communications. 17, 1, 997.
Research output: Contribution to journal › Comment/debate

Open Access
Directional guidance to orient Schwann cell alignment in nerve regeneration requires Plexin-B1
Li, J., Ni, H., Halawani, D., Estill, M., Ramakrishnan, A., Alves, C. J., Shen, L., He, X., Friedel, R. H. & Zou, H., 24 Apr 2026, In: Science advances. 12, 17, p. eadw4136
Research output: Contribution to journal › Article › peer-review

Open Access
Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease
Llibre-Guerra, J. J., Lu, R., Clarens, M. F., Liu, I., Renton, A., Ryan, N. S., Goate, A. M., Aguillón, D., Allegri, R. F., Benzinger, T. L. S., Berman, S., Chhatwal, J. P., Chrem Mendez, P., Vigo, G., Cruchaga, C., Day, G. S., Farlow, M. R., Fox, N. C., Gordon, B. A. & Hassenstab, J. & 20 others, Huey, E. D., Ibanez, L., Ikeuchi, T., Jucker, M., Lee, J. H., Levey, A. I., Levin, J., Niimi, Y., Perrin, R. J., Rosa-Neto, P., Sánchez-Valle, R., Schofield, P. R., Wang, G., Li, Y., Xiong, C., Morris, J. C., Karch, C., Daniels, A. J., McDade, E. & Bateman, R. J., 28 Apr 2026, In: Neurology. 106, 8, p. e214804
Research output: Contribution to journal › Article › peer-review

Open Access
Evaluating the causal effect of mitochondrial dysfunction on Alzheimer's disease and Parkinson's disease using polygenic risk scores and Mendelian randomization
for the Alzheimer's Disease Genetics Consortium and the Alzheimer's Disease Neuroimaging Initiative, May 2026, In: Alzheimer's and Dementia. 22, 5, e71469.
Research output: Contribution to journal › Article › peer-review

Open Access
Generation of the induced pluripotent stem cell line ISMMSi061-A from a patient with ataxia, intention tremor, and hypotonia syndrome, childhood-onset
Liu, N. N., Hu, R., Hubbard, S. J., Salemi, S. E., Baljinnyam, E., Pradhan, P., Smith, G., Webb, B. D. & Marro, S. G., Apr 2026, In: Stem Cell Research. 92, 103938.
Research output: Contribution to journal › Article › peer-review

Open Access
Genetic modifiers of APOE-ε4-associated cognitive decline
the Alzheimer's Disease Neuroimaging Initiative (ADNI), Alzheimer's Disease Genetics Consortium (ADGC) & The Alzheimer’s Disease Sequencing Project (ADSP), Dec 2026, In: Nature Communications. 17, 1, 2982.
Research output: Contribution to journal › Article › peer-review

Open Access
Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study
Dominantly Inherited Alzheimer Network, Jun 2026, In: The Lancet Neurology. 25, 6, p. 581-590 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
Integrative Genomics Approach Identifies Glial Transcriptomic Dysregulation and Risk in the Cortex of Individuals With Alcohol Use Disorder
Warden, A. S., Salem, N. A., Brenner, E., Sutherland, G. T., Stevens, J., Kapoor, M., Goate, A. M. & Mayfield, R. D., 1 Jan 2026, In: Biological Psychiatry. 99, 1, p. 34-48 15 p.
Research output: Contribution to journal › Article › peer-review
7 Scopus citations
Longitudinal subcortical volume changes and their correlations with multiple PET and fluid biomarkers in dominantly inherited Alzheimer’s disease
Choo, I. H., Park, H., Gordon, B. A., Bateman, R. J., Bateman, R., Daniels, A. J., Courtney, L., Ziegemeier, A., Skrbec, K., Hellm, C., Martin, M., Ziegemeier, E., Bartzel, J., McDade, E., Libre-Guerra, J. J., Supnet-Bell, C., Xiong, C., Xu, X., Lu, R. & Wang, G. & 106 others, Li, Y., Nie, Y., Gremminger, E., Perrin, R. J., Franklin, E., Ibanez, L., Jerome, G., Stauber, J., Baker, B., Minton, M., Cruchaga, C., Goate, A. M., Renton, A. E., Picarello, D. M., Fulton-Howard, B., Benzinger, T. L. S., Gordon, B. A., Banks, J., Hornbeck, R., Chen, A., Chen, C., Flores, S., Goyal, M., Hobbs, D., Joseph-Mathurin, N., Jackson, K., Keefe, S., Koudelis, D., Massoumzadeh, P., McCullough, A., McKay, N., Nicklaus, J., Pulizos, C., Wang, Q., Sabaredzovic, E., Scott, J., Simmons, A., Rizzo, J., Vlassenko, A., Wang, Y., Hassenstab, J., Smith, J., Stout, S., Aschenbrenner, A. J., Karch, C. M., Marsh, J., Morris, J. C., Holzman, D. M., Barthélemy, N. R., Xu, J., Berman, S. B., Ikonomovic, S., Day, G. S., Graff-Radford, N. R., Farlow, M., Chhatwal, J. P., Ikeuchi, T., Kasuga, K., Ishiguro, T., Ishii, K., Senda, M., Niimi, Y., Huey, E. D., Salloway, S., Devenney, E., Schofield, P. R., Brooks, W. S., Bechara, J. A., Martins, R., Fox, N. C., Cash, D. M., Ryan, N. S., Jucker, M., Laske, C., Timofejavaite, R., Kuder-Buletta, E., Graber-Sultan, S., la Fougère, C., Reischl, G., Obermueller, U., Levin, J., Rödenbeck, Y., Vöglein, J., Lee, J. H., Roh, J. H., Vitali, P., Allegri, R. F., Mendez, P. C., Surace, E., Vazquez, S., Aguillon, D., Leon, Y. M., Ramirez, L., Serna, L., Baena, A., Bocanegra, Y., Levey, A. I., Johnson, E. C. B., Seyfried, N. T., Ringman, J., Fagan, A. M., Mori, H., Masters, C., Nobles, J. M., Sanchez-Valle, R. & Lopera, F., Apr 2026, In: Journal of Prevention of Alzheimer's Disease. 13, 4, 100513.
Research output: Contribution to journal › Article › peer-review

Open Access
Mapping the genetic landscape across 14 psychiatric disorders
Nicotine Dependence GenOmics (iNDiGO) Consortium, Obsessive-Compulsive Disorder and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium, Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, Anxiety Disorders Working Group of the Psychiatric Genomics Consortium, Attention-Deficit/Hyperactivity Disorder (ADHD) Working Group of the Psychiatric Genomics Consortium, Autism Spectrum Disorders Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 8 Jan 2026, In: Nature. 649, 8096, p. 406-415 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
32 Scopus citations

Creative Biolabs' Webinar Explores New Mechanisms Driving Neurodegeneration
Blanchard, J.
5/06/26
68 items of Media coverage
Press/Media
New Findings from Icahn School of Medicine at Mount Sinai Describe Advances in Parkinson's Disease (Evaluating the causal effect of mitochondrial dysfunction on Alzheimer's disease and Parkinson's disease using polygenic risk scores and ...)
Goate, A.
29/05/26
1 item of Media coverage
Press/Media
Researchers at Icahn School of Medicine at Mount Sinai Report Findings in Alzheimer Disease (Single-cell transcriptomic analysis reveals APOE genotype-dependent sex differences in Alzheimer's disease)
Wang, M. & Goate, A.
22/05/26
1 item of Media coverage
Press/Media
Researchers from Icahn School of Medicine at Mount Sinai Report Findings in Pain and Central Nervous System (ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte Toxicity)
Blanchard, J. & Parfitt, G.
18/05/26
1 item of Media coverage
Press/Media
Data from Neural Stem Cell Institute Provide New Insights into Age-Related Macular Degeneration (IND-enabling safety and efficacy of RPESC-RPE-4W, an adult RPE progenitor cell therapy for dry age-related macular degeneration)
Blenkinsop, T.
11/05/26
1 item of Media coverage
Press/Media
Handling the risks of carrying the 'Alzheimer's gene'
Goate, A.
4/05/26
1 item of Media coverage
Press/Media
What carrying the ‘Alzheimer’s gene’ like Chris Hemsworth means and how to reduce risk
Goate, A.
4/05/26
1 item of Media coverage
Press/Media
Researchers at Washington University School of Medicine Discuss Findings in Alzheimer Disease (Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease)
Goate, A.
22/04/26
1 item of Media coverage
Press/Media
Alzheimer’s Brains Share a Genetic Signature with Some Cancers
Kaplan,, S., Papapetrou, E., Marro, S. & Walsh, C.
21/04/26
1 item of Media coverage
Press/Media
Researchers from Washington University Discuss Findings in Disease Biomarkers (The relationship between alcohol use disorder, measures of cognitive decline, and Alzheimer disease biomarkers in middle aged and older adults)
Goate, A.
17/04/26
1 item of Media coverage
Press/Media
HMN 2026: How Molecular ‘brake’ limits axonal regeneration after injury to nerves or spinal cord
Zou, H.
10/04/26
1 item of Media coverage
Press/Media
Researchers from Icahn School of Medicine at Mount Sinai Detail Findings in Aryl Hydrocarbon Receptor (AhR inhibition promotes axon regeneration via a stress-growth switch)
Friedel, R., Zou, H. & Halawani, D.
10/04/26
1 item of Media coverage
Press/Media

Alper Center for Neural Development and Regeneration

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Collaborations and top research areas from the last five years

Dive into details

Deanna Benson

Joel Blanchard

Timothy Blenkinsop

Joseph Castellano

Roland Friedel

Alison Goate

Samuele Marro

Nadejda Tsankova

Nan Yang

Hongyan Zou

Thomas Zwaka

AhR inhibition promotes axon regeneration via a stress–growth switch

A meta-analysis of single-nucleus expression quantitative trait loci linking genetic risk to brain disorders

Author Correction: A streamlined base editor engineering strategy to reduce bystander editing (Nature Communications, (2025), 16, 1, (8115), 10.1038/s41467-025-63609-6)

Directional guidance to orient Schwann cell alignment in nerve regeneration requires Plexin-B1

Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease

Evaluating the causal effect of mitochondrial dysfunction on Alzheimer's disease and Parkinson's disease using polygenic risk scores and Mendelian randomization

Generation of the induced pluripotent stem cell line ISMMSi061-A from a patient with ataxia, intention tremor, and hypotonia syndrome, childhood-onset

Genetic modifiers of APOE-ε4-associated cognitive decline

Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study

Integrative Genomics Approach Identifies Glial Transcriptomic Dysregulation and Risk in the Cortex of Individuals With Alcohol Use Disorder

Longitudinal subcortical volume changes and their correlations with multiple PET and fluid biomarkers in dominantly inherited Alzheimer’s disease

Mapping the genetic landscape across 14 psychiatric disorders

Creative Biolabs' Webinar Explores New Mechanisms Driving Neurodegeneration

New Findings from Icahn School of Medicine at Mount Sinai Describe Advances in Parkinson's Disease (Evaluating the causal effect of mitochondrial dysfunction on Alzheimer's disease and Parkinson's disease using polygenic risk scores and ...)

Researchers at Icahn School of Medicine at Mount Sinai Report Findings in Alzheimer Disease (Single-cell transcriptomic analysis reveals APOE genotype-dependent sex differences in Alzheimer's disease)

Researchers from Icahn School of Medicine at Mount Sinai Report Findings in Pain and Central Nervous System (ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte Toxicity)

Data from Neural Stem Cell Institute Provide New Insights into Age-Related Macular Degeneration (IND-enabling safety and efficacy of RPESC-RPE-4W, an adult RPE progenitor cell therapy for dry age-related macular degeneration)

Handling the risks of carrying the 'Alzheimer's gene'

What carrying the ‘Alzheimer’s gene’ like Chris Hemsworth means and how to reduce risk

Researchers at Washington University School of Medicine Discuss Findings in Alzheimer Disease (Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease)

Alzheimer’s Brains Share a Genetic Signature with Some Cancers

Researchers from Washington University Discuss Findings in Disease Biomarkers (The relationship between alcohol use disorder, measures of cognitive decline, and Alzheimer disease biomarkers in middle aged and older adults)

HMN 2026: How Molecular ‘brake’ limits axonal regeneration after injury to nerves or spinal cord

Researchers from Icahn School of Medicine at Mount Sinai Detail Findings in Aryl Hydrocarbon Receptor (AhR inhibition promotes axon regeneration via a stress-growth switch)

Alper Center for Neural Development and Regeneration

Fingerprint

Collaborations and top research areas from the last five years

Profiles

Research output

Press/Media