Alper Center for Neural Development and Regeneration

Icahn School of Medicine at Mount Sinai

1588 Citations
20 h-index
102 Article
13 Review article
6 Comment/debate
1 Chapter
More

APOE genotype and brain amyloid are associated with changes in the plasma proteome in elderly subjects without dementia
Philippi, S. M., Kailash, B. P., Raj, T. & Castellano, J. M., Feb 2025, In: Annals of Clinical and Translational Neurology. 12, 2, p. 366-382 17 p.
Research output: Contribution to journal › Article › peer-review

Open Access
CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer’s disease risk
Nguyen, L., Ajredini, R., Guo, S., Romano, L. E. L., Tomas, R. F., Bell, L. R., Ranum, P. T., Zu, T., Coronel, M. B., Kelley, C. P., Redding-Ochoa, J., Nizamis, E., Melloni, A., Connors, T. R., Gaona, A., Thangaraju, K., Pletnikova, O., Brent Clark, H., Davidson, B. L. & Yachnis, A. T. & 10 others, Golde, T. E., Lou, X. Y., Wang, E. T., Renton, A. E., Goate, A., Valdmanis, P. N., Prokop, S., Troncoso, J. C., Hyman, B. T. & Ranum, L. P. W., 19 Feb 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 7, e2416885122.
Research output: Contribution to journal › Article › peer-review

Open Access
Correction to: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction (Nature Neuroscience, (2021), 24, 10, (1367-1376), 10.1038/s41593-021-00908-3)
COGA Collaborators, Jan 2025, In: Nature Neuroscience. 28, 1, p. 213 1 p.
Research output: Contribution to journal › Comment/debate

Open Access
Generation of induced pluripotent stem cell line ISMMSi060-A from a patient with combined oxidative phosphorylation deficiency 25
Salemi, S. E., Baljinnyam, E., Liu, N. N., Hu, R., Marro, S. G. & Webb, B. D., Mar 2025, In: Stem Cell Research. 83, 103662.
Research output: Contribution to journal › Article › peer-review

Open Access
Identification of Meibomian gland stem cell populations and mechanisms of aging
Zhu, X., Xu, M., Portal, C., Lin, Y., Ferdinand, A., Peng, T., Morrisey, E. E., Dlugosz, A. A., Castellano, J. M., Lee, V., Seykora, J. T., Wong, S. Y., Iomini, C. & Millar, S. E., Dec 2025, In: Nature Communications. 16, 1, 1663.
Research output: Contribution to journal › Article › peer-review

Open Access
Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer’s disease
Dominantly Inherited Alzheimer Network (DIAN), Dec 2025, In: Alzheimer's Research and Therapy. 17, 1, 5.
Research output: Contribution to journal › Article › peer-review

Open Access
Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2
Junqueira Alves, C., Hannah, T., Sadia, S., Kolsteeg, C., Dixon, A., Wiener, R. J., Nguyen, H., Tipping, M. J., Silva Ladeira, J., Fernandes da Costa Franklin, P., de Paula Dutra de Nigro, N., Alves Dias, R., Zabala Capriles, P. V., Rodrigues Furtado de Mendonça, J. P., Slesinger, P. A., Costa, K. D., Zou, H. & Friedel, R. H., Dec 2025, In: Nature Communications. 16, 1, 272.
Research output: Contribution to journal › Article › peer-review

Open Access
Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia
on behalf of the Dominantly Inherited Alzheimer Network, 2025, (Accepted/In press) In: Nature Medicine. 1711.e15.
Research output: Contribution to journal › Article › peer-review
Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus
Matera, A., Compagnion, A. C., Pedicone, C., Kotah, J. M., Ivanov, A., Monsorno, K., Labouèbe, G., Leggio, L., Pereira-Iglesias, M., Beule, D., Mansuy-Aubert, V., Williams, T. L., Iraci, N., Sierra, A., Marro, S. G., Goate, A. M., Eggen, B. J. L., Kerr, W. G. & Paolicelli, R. C., 14 Jan 2025, In: Immunity. 58, 1, p. 197-217.e13
Research output: Contribution to journal › Article › peer-review

Open Access
Spatial proteomic differences in chronic traumatic encephalopathy, Alzheimer's disease, and primary age-related tauopathy hippocampi
Richardson, T. E., Orr, M. E., Orr, T. C., Rohde, S. K., Ehrenberg, A. J., Thorn, E. L., Christie, T. D., Flores-Almazan, V., Afzal, R., De Sanctis, C., Maldonado-Díaz, C., Hiya, S., Canbeldek, L., Kulumani Mahadevan, L. S., Slocum, C., Samanamud, J., Clare, K., Scibetta, N., Yokoda, R. T. & Koenigsberg, D. & 18 others, Marx, G. A., Kauffman, J., Goldstein, A., Selmanovic, E., Drummond, E., Wisniewski, T., White, C. L., Goate, A. M., Crary, J. F., Farrell, K., Alosco, M. L., Mez, J., McKee, A. C., Stein, T. D., Bieniek, K. F., Kautz, T. F., Daoud, E. V. & Walker, J. M., Feb 2025, In: Alzheimer's and Dementia. 21, 2, e14487.
Research output: Contribution to journal › Article › peer-review

Open Access
Abortive infection of bat fibroblasts with SARS-CoV-2
Bisht, P., Gallagher, M. D., Barrasa, M. I., Boucau, J., Harding, A., Déjosez, M., Godoy-Parejo, C., Bisher, M. E., de Nola, G., Lytton-Jean, A. K. R., Gehrke, L., Zwaka, T. P. & Jaenisch, R., 22 Oct 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 43, e2406773121.
Research output: Contribution to journal › Article › peer-review

Open Access
A common flanking variant is associated with enhanced stability of the FGF14-SCA27B repeat locus
All of Us Research Program Long Read Working Group, Jul 2024, In: Nature Genetics. 56, 7, p. 1366-1370 5 p.
Research output: Contribution to journal › Article › peer-review
7 Scopus citations

Findings in Chromatin Reported from Icahn School of Medicine at Mount Sinai (Single Chromatin Fiber Profiling and Nucleosome Position Mapping In the Human Brain)
Dawson, T., Sebra, R., Akbarian, S., Roussos, P., Tsankova, N. & Girdhar, K.
26/02/25
1 item of Media coverage
Press/Media
U.S. Patents Awarded to Inventors in Massachusetts (Jan. 27)
Blanchard, J.
27/01/25
1 item of Media coverage
Press/Media
Icahn School of Medicine at Mount Sinai Researcher Details Findings in Alzheimer Disease (Neuroimmune regulation of Alzheimer's pathology by age-related blood-borne factors)
Hemmer, B. & Castellano,, J.
24/01/25
1 item of Media coverage
Press/Media
Small Molecule Suppressors of APOE Gene Expression and Cerebral Vascular Amyloid Pathology
Blanchard, J.
21/01/25
1 item of Media coverage
Press/Media
Icahn School of Medicine at Mount Sinai Researchers Update Current Data on Gliomas (Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2)
Wiener, R., Costa, K., Friedel, R., Slesinger, P. & Zou, H.
17/01/25
1 item of Media coverage
Press/Media
Cure Alzheimer’s Fund Expands Research Leadership Group with Six Distinguished Scientists
Goate, A.
14/01/25
1 item of Media coverage
Press/Media
CURE ALZHEIMER'S FUND NAMES SIX NEW MEMBERS TO ITS RESEARCH LEADERSHIP GROUP
Goate, A.
14/01/25
1 item of Media coverage
Press/Media
CURE ALZHEIMER’S FUND NAMES SIX NEW MEMBERS TO ITS RESEARCH LEADERSHIP GROUP
Goate, A.
14/01/25
21 items of Media coverage
Press/Media
CURE ALZHEIMER'S FUND NAMES SIX NEW MEMBERS TO ITS RESEARCH LEADERSHIP GROUP
Goate, A.
14/01/25
1 item of Media coverage
Press/Media
Is Your Brain Aging Fast? Plasma Proteins Might Tell
Castellano,, J.
11/12/24
1 item of Media coverage
Press/Media
Icahn School of Medicine at Mount Sinai Reports Findings in Gliomas (Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations)
Becher, O., Morgenstern,, P. & Tsankova, N.
30/10/24
1 item of Media coverage
Press/Media
Findings from Cleveland Clinic Provides New Data on Alzheimer Disease (Widespread Transposable Element Dysregulation In Human Aging Brains With Alzheimer's Disease)
Goate, A.
30/10/24
1 item of Media coverage
Press/Media